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Combinatorial Approach to Improve Cancer Immunotherapy: Rational Drug Design Strategy to Simultaneously Hit Multiple Targets to Kill Tumor Cells and to Activate the Immune System

Journal of oncology, 2019-01, Vol.2019, p.5245034-18

2019

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Rac2 controls tumor growth, metastasis and M1-M2 macrophage differentiation in vivo

PloS one, 2014-04, Vol.9 (4), p.e95893-e95893

2014

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Recent advances in multitarget-directed ligands via in silico drug discovery

Drug discovery today, 2024-03, Vol.29 (3), p.103904-103904, Article 103904

2024

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A macrophage-dominant PI3K isoform controls hypoxia-induced HIF1α and HIF2α stability and tumor growth, angiogenesis, and metastasis

Molecular cancer research, 2014-10, Vol.12 (10), p.1520-1531

2014

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MDM2 Regulates Hypoxic Hypoxia-inducible Factor 1α Stability in an E3 Ligase, Proteasome, and PTEN-Phosphatidylinositol 3-Kinase-AKT-dependent Manner

The Journal of biological chemistry, 2014-08, Vol.289 (33), p.22785-22797

2014

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The differential ability of asparagine and glutamine in promoting the closed/active enzyme conformation rationalizes the Wolinella succinogenes L-asparaginase substrate specificity

Scientific reports, 2017-01, Vol.7 (1), p.41643-41643, Article 41643

2017

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Induction of autophagy by PI3K/MTOR and PI3K/MTOR/BRD4 inhibitors suppresses HIV-1 replication

The Journal of biological chemistry, 2018-04, Vol.293 (16), p.5808-5820

2018

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Nilotinib, an approved leukemia drug, inhibits smoothened signaling in Hedgehog-dependent medulloblastoma

PloS one, 2019-09, Vol.14 (9), p.e0214901

2019

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Rac2 is required for alternative macrophage activation and bleomycin induced pulmonary fibrosis; a macrophage autonomous phenotype

PloS one, 2017-08, Vol.12 (8), p.e0182851

2017

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Vascular Permeability and Remodelling Coincide with Inflammatory and Reparative Processes after Joint Bleeding in Factor VIII-Deficient Mice

Thrombosis and haemostasis, 2018-06, Vol.118 (6), p.1036

2018

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Dual-activity PI3K–BRD4 inhibitor for the orthogonal inhibition of MYC to block tumor growth and metastasis

Proceedings of the National Academy of Sciences - PNAS, 2017-02, Vol.114 (7), p.E1072-E1080

2017

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Binding of the SARS-CoV-2 envelope E protein to human BRD4 is essential for infection

Structure (London), 2022-09, Vol.30 (9), p.1224-1232.e5

2022

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'Pseudopalisading' Necrosis in Glioblastoma: A Familiar Morphologic Feature That Links Vascular Pathology, Hypoxia, and Angiogenesis

Journal of neuropathology and experimental neurology, 2006-06, Vol.65 (6), p.529-539

2006

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PI-3K Inhibitors Preferentially Target CD15+ Cancer Stem Cell Population in SHH Driven Medulloblastoma

PloS one, 2016-03, Vol.11 (3), p.e0150836-e0150836

2016

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SRX3177, a CDK4/6-PI3K-BET inhibitor, in combination with an RdRp inhibitor, Molnupiravir, or an entry inhibitor MU-UNMC-2, has potent antiviral activity against the Omicron variant of SARS-CoV-2

Antiviral research, 2024-07, Vol.227, p.105904, Article 105904

2024

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Knockout Serum Replacement Promotes Cell Survival by Preventing BIM from Inducing Mitochondrial Cytochrome C Release

PloS one, 2015-10, Vol.10 (10), p.e0140585

2015

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COVID-19 and Cancer Comorbidity: Therapeutic Opportunities and Challenges

Theranostics, 2021-01, Vol.11 (2), p.731-753

2021

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Vascular remodeling underlies rebleeding in hemophilic arthropathy

American journal of hematology, 2015-11, Vol.90 (11), p.1027-1035

2015

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Regulation of XIAP Translation and Induction by MDM2 following Irradiation

Cancer cell, 2009-05, Vol.15 (5), p.363-375

2009

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SF2523: Dual PI3K/BRD4 Inhibitor Blocks Tumor Immunosuppression and Promotes Adaptive Immune Responses in Cancer

Molecular cancer therapeutics, 2019-06, Vol.18 (6), p.1036-1044

2019

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Mechanisms of Disease: the PI3K-Akt-PTEN signaling node-an intercept point for the control of angiogenesis in brain tumors

Nature clinical practice. Neurology, 2007-12, Vol.3 (12), p.682-693

2007

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Preclinical activity of a novel multi-axis inhibitor in aggressive and indolent B-cell malignancies

Leukemia & lymphoma, 2023-12, Vol.64 (14), p.2333-2337

2023

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Augmented Antitumor Activity for Novel Dual PI3K/BDR4 Inhibitors, SF2523 and SF1126 in Ewing Sarcoma

Journal of pediatric hematology/oncology, 2021-04, Vol.43 (3), p.e304

2021

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The Protein Phosphatase Activity of PTEN Regulates Src Family Kinases and Controls Glioma Migration

Cancer research (Chicago, Ill.), 2008-03, Vol.68 (6), p.1862-1871

2008

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Single Agent and Synergistic Activity of the "First-in-Class" Dual PI3K/BRD4 Inhibitor SF1126 with Sorafenib in Hepatocellular Carcinoma

Molecular cancer therapeutics, 2016-11, Vol.15 (11), p.2553-2562

2016

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Combinatorial Approach to Improve Cancer Immunotherapy: Rational Drug Design Strategy to Simultaneously Hit Multiple Targets to Kill Tumor Cells and to Activate the Immune System

Rac2 controls tumor growth, metastasis and M1-M2 macrophage differentiation in vivo

Recent advances in multitarget-directed ligands via in silico drug discovery

A macrophage-dominant PI3K isoform controls hypoxia-induced HIF1α and HIF2α stability and tumor growth, angiogenesis, and metastasis

MDM2 Regulates Hypoxic Hypoxia-inducible Factor 1α Stability in an E3 Ligase, Proteasome, and PTEN-Phosphatidylinositol 3-Kinase-AKT-dependent Manner

The differential ability of asparagine and glutamine in promoting the closed/active enzyme conformation rationalizes the Wolinella succinogenes L-asparaginase substrate specificity

Induction of autophagy by PI3K/MTOR and PI3K/MTOR/BRD4 inhibitors suppresses HIV-1 replication

Nilotinib, an approved leukemia drug, inhibits smoothened signaling in Hedgehog-dependent medulloblastoma

Rac2 is required for alternative macrophage activation and bleomycin induced pulmonary fibrosis; a macrophage autonomous phenotype

Vascular Permeability and Remodelling Coincide with Inflammatory and Reparative Processes after Joint Bleeding in Factor VIII-Deficient Mice

Dual-activity PI3K–BRD4 inhibitor for the orthogonal inhibition of MYC to block tumor growth and metastasis

Binding of the SARS-CoV-2 envelope E protein to human BRD4 is essential for infection

'Pseudopalisading' Necrosis in Glioblastoma: A Familiar Morphologic Feature That Links Vascular Pathology, Hypoxia, and Angiogenesis

PI-3K Inhibitors Preferentially Target CD15+ Cancer Stem Cell Population in SHH Driven Medulloblastoma

SRX3177, a CDK4/6-PI3K-BET inhibitor, in combination with an RdRp inhibitor, Molnupiravir, or an entry inhibitor MU-UNMC-2, has potent antiviral activity against the Omicron variant of SARS-CoV-2

Knockout Serum Replacement Promotes Cell Survival by Preventing BIM from Inducing Mitochondrial Cytochrome C Release

COVID-19 and Cancer Comorbidity: Therapeutic Opportunities and Challenges

Vascular remodeling underlies rebleeding in hemophilic arthropathy

Regulation of XIAP Translation and Induction by MDM2 following Irradiation

SF2523: Dual PI3K/BRD4 Inhibitor Blocks Tumor Immunosuppression and Promotes Adaptive Immune Responses in Cancer

Mechanisms of Disease: the PI3K-Akt-PTEN signaling node-an intercept point for the control of angiogenesis in brain tumors

Preclinical activity of a novel multi-axis inhibitor in aggressive and indolent B-cell malignancies

Augmented Antitumor Activity for Novel Dual PI3K/BDR4 Inhibitors, SF2523 and SF1126 in Ewing Sarcoma

The Protein Phosphatase Activity of PTEN Regulates Src Family Kinases and Controls Glioma Migration

Single Agent and Synergistic Activity of the "First-in-Class" Dual PI3K/BRD4 Inhibitor SF1126 with Sorafenib in Hepatocellular Carcinoma

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