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Synthesis and Pharmacological Evaluation of N-(2,5-Disubstituted phenyl)-N‘-(3-substituted phenyl)-N‘-methylguanidines As N-Methyl-d-aspartate Receptor Ion-Channel Blockers

Journal of medicinal chemistry, 1997-12, Vol.40 (26), p.4281-4289

1997

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Pharmacological characterization of GT-2016, a non-thiourea-containing histamine H3 receptor antagonist: in vitro and in vivo studies

The Journal of pharmacology and experimental therapeutics, 1995-11, Vol.275 (2), p.598

1995

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The pharmacology of cimetidine, a new histamine H 2 ‐receptor antagonist

British journal of pharmacology, 2010-07, Vol.160 (s1)

2010

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Synthesis and Pharmacological Evaluation of N,N‘-Diarylguanidines as Potent Sodium Channel Blockers and Anticonvulsant Agents

Journal of medicinal chemistry, 1998-08, Vol.41 (17), p.3298-3302

1998

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The pharmacology of cimetidine, a new histamine H2-receptor antagonist. 1975

British journal of pharmacology, 2010-07, Vol.160 Suppl 1, p.S52-S53

2010

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Guanidine derivatives acting at histaminergic receptors

Chemical Society reviews, 1985, Vol.14 (4), p.375

Durant, G. J.

1985

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Design, Synthesis, and Pharmacological Evaluation of Conformationally Constrained Analogues of N,N‘-Diaryl- and N-Aryl-N-aralkylguanidines as Potent Inhibitors of Neuronal Na+ Channels

Journal of medicinal chemistry, 1998-07, Vol.41 (16), p.3048-3061

1998

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The histamine H2-receptor agonist impromidine: synthesis and structure activity considerations

Journal of medicinal chemistry, 1985-10, Vol.28 (10), p.1414-1422

1985

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Cyanoguanidine-thiourea equivalence in the development of the histamine H2-receptor antagonist, cimetidine

Journal of medicinal chemistry, 1977-07, Vol.20 (7), p.901-906

1977

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Impromidine (SK&F 92676) is a very potent and specific agonist for histamine H2 receptors

Nature (London), 1978-11, Vol.276 (5686), p.403-405

1978

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Design, Synthesis, and Neurochemical Evaluation of 2-Amino-5-(alkoxycarbonyl)-3,4,5,6-tetrahydropyridines and 2-Amino-5-(alkoxycarbonyl)-1,4,5,6-tetrahydropyrimidines as M1 Muscarinic Receptor Agonists

Journal of medicinal chemistry, 1994-08, Vol.37 (17), p.2774-2782

1994

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Design, synthesis, and neurochemical evaluation of 5-(3-alkyl-1,2,4-oxadiazol-5-yl)-1,4,5,6-tetrahydropyrimidines as M1 muscarinic receptor agonists

Journal of medicinal chemistry, 1993-04, Vol.36 (7), p.842-847

1993

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Solution-Phase, parallel synthesis and pharmacological evaluation of acylguanidine derivatives as potential sodium channel blockers

Bioorganic & medicinal chemistry letters, 2001-12, Vol.11 (24), p.3151-3155

2001

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Characterization and development of cimetidine as a histamine H2-receptor antagonist

Gastroenterology (New York, N.Y. 1943), 1978-02, Vol.74 (2), p.339-347

1978

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Structures of histamine H1-receptor antagonists derived from the cimetidine group of histamine H2-receptor antagonists

Acta crystallographica. Section B, Structural science, 1994-04, Vol.50 (2), p.221-243

1994

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Toxicity of H2-receptor antagonists to isolated rat hepatocytes: structure-activity relationships

The Journal of pharmacology and experimental therapeutics, 1988-01, Vol.244 (1), p.113

1988

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Theoretical studies on hydration of pyrrole, imidazole, and protonated imidazole in the gas phase and aqueous solution

Journal of the American Chemical Society, 1993-04, Vol.115 (7), p.2912-2922

1993

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Identification and characterization of a potential ischemia-selective N-methyl- d-aspartate (NMDA) receptor ion-channel blocker, CNS 5788

Bioorganic & medicinal chemistry letters, 2001-02, Vol.11 (4), p.501-504

2001

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Structure of oxmetidine dihydrochloride (SKF 92994)

Acta crystallographica. Section C, Crystal structure communications, 1993-01, Vol.49 (1), p.44-46

1993

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Synthesis and biochemical activity of novel amidine derivatives as m1 muscarinic receptor agonists

Bioorganic & medicinal chemistry, 1996-10, Vol.4 (10), p.1605-1615

1996

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Structure-activity studies of pyridinylalkyl-isocytosine H1-receptor antihistamines and identification of an active conformation

Farmaco (Società chimica italiana : 1989), 1991-01, Vol.46 (1), p.3

1991

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N-(3-Azidophenyl)-N-methyl-N'-([4-1H]- and [4-3H]-1-naphthyl)guanidine. A potent and selective ligand designed as a photoaffinity label for the phencyclidine site of the N-methyl-D-aspartate receptor

Bioconjugate chemistry, 1993-05, Vol.4 (3), p.226-229

1993

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Asymmetric synthesis of a neuroprotective and orally active N-methyl- d-aspartate receptor ion-channel blocker, CNS 5788

Tetrahedron: asymmetry, 2000-09, Vol.11 (17), p.3455-3457

2000

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The pharmacology of cimetidine, a new histamine H2‐receptor antagonist

British journal of pharmacology, 2010-07, Vol.160 (Suppl 1), p.S52-S53

2010

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Some theoretical aspects on morphology development in seeded composite latexes. I: Batch conditions below monomer saturation

Colloid and polymer science, 1993-06, Vol.271 (6), p.607-615

1993

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Synthesis and Pharmacological Evaluation of N-(2,5-Disubstituted phenyl)-N‘-(3-substituted phenyl)-N‘-methylguanidines As N-Methyl-d-aspartate Receptor Ion-Channel Blockers

Pharmacological characterization of GT-2016, a non-thiourea-containing histamine H3 receptor antagonist: in vitro and in vivo studies

The pharmacology of cimetidine, a new histamine H 2 ‐receptor antagonist

Synthesis and Pharmacological Evaluation of N,N‘-Diarylguanidines as Potent Sodium Channel Blockers and Anticonvulsant Agents

The pharmacology of cimetidine, a new histamine H2-receptor antagonist. 1975

Guanidine derivatives acting at histaminergic receptors

Design, Synthesis, and Pharmacological Evaluation of Conformationally Constrained Analogues of N,N‘-Diaryl- and N-Aryl-N-aralkylguanidines as Potent Inhibitors of Neuronal Na+ Channels

The histamine H2-receptor agonist impromidine: synthesis and structure activity considerations

Cyanoguanidine-thiourea equivalence in the development of the histamine H2-receptor antagonist, cimetidine

Impromidine (SK&F 92676) is a very potent and specific agonist for histamine H2 receptors

Design, Synthesis, and Neurochemical Evaluation of 2-Amino-5-(alkoxycarbonyl)-3,4,5,6-tetrahydropyridines and 2-Amino-5-(alkoxycarbonyl)-1,4,5,6-tetrahydropyrimidines as M1 Muscarinic Receptor Agonists

Design, synthesis, and neurochemical evaluation of 5-(3-alkyl-1,2,4-oxadiazol-5-yl)-1,4,5,6-tetrahydropyrimidines as M1 muscarinic receptor agonists

Solution-Phase, parallel synthesis and pharmacological evaluation of acylguanidine derivatives as potential sodium channel blockers

Characterization and development of cimetidine as a histamine H2-receptor antagonist

Structures of histamine H1-receptor antagonists derived from the cimetidine group of histamine H2-receptor antagonists

Toxicity of H2-receptor antagonists to isolated rat hepatocytes: structure-activity relationships

Theoretical studies on hydration of pyrrole, imidazole, and protonated imidazole in the gas phase and aqueous solution

Identification and characterization of a potential ischemia-selective N-methyl- d-aspartate (NMDA) receptor ion-channel blocker, CNS 5788

Structure of oxmetidine dihydrochloride (SKF 92994)

Synthesis and biochemical activity of novel amidine derivatives as m1 muscarinic receptor agonists

Structure-activity studies of pyridinylalkyl-isocytosine H1-receptor antihistamines and identification of an active conformation

N-(3-Azidophenyl)-N-methyl-N'-([4-1H]- and [4-3H]-1-naphthyl)guanidine. A potent and selective ligand designed as a photoaffinity label for the phencyclidine site of the N-methyl-D-aspartate receptor

Asymmetric synthesis of a neuroprotective and orally active N-methyl- d-aspartate receptor ion-channel blocker, CNS 5788

The pharmacology of cimetidine, a new histamine H2‐receptor antagonist

Some theoretical aspects on morphology development in seeded composite latexes. I: Batch conditions below monomer saturation

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