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The Human Cathelicidin Antimicrobial Peptide LL-37 as a Potential Treatment for Polymicrobial Infected Wounds

Frontiers in immunology, 2013-01, Vol.4, p.143-143

2013

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Mitigating the Impact of Antibacterial Drug Resistance through Host-Directed Therapies: Current Progress, Outlook, and Challenges

mBio, 2018-01, Vol.9 (1)

2018

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Searching for Therapeutics Against Botulinum Neurotoxins: A True Challenge for Drug Discovery

Current topics in medicinal chemistry, 2016-09, Vol.16 (21), p.2330

2016

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Synthesis of [ 18 F]Favipiravir and Biodistribution in C3H/HeN Mice as Assessed by Positron Emission Tomography

Scientific reports, 2019-02, Vol.9 (1), p.1785-1785, Article 1785

2019

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Vinyl Sulfone-Based Inhibitors of Nonstructural Protein 2 Block the Replication of Venezuelan Equine Encephalitis Virus

ACS medicinal chemistry letters, 2020-11, Vol.11 (11), p.2139-2145

2020

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Discovery, SAR, and Pharmacokinetics of a Novel 3-Hydroxyquinolin-2(1H)-one Series of Potent d-Amino Acid Oxidase (DAAO) Inhibitors

Journal of medicinal chemistry, 2009-06, Vol.52 (11), p.3576-3585

2009

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Modulation of NMDA receptor function by inhibition of d-amino acid oxidase in rodent brain

Neuropharmacology, 2011-10, Vol.61 (5), p.1001-1015

2011

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Recent successes in therapeutics for Ebola virus disease: no time for complacency

The Lancet infectious diseases, 2020-09, Vol.20 (9), p.e231-e237

2020

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Cholesterol-conjugated stapled peptides inhibit Ebola and Marburg viruses in vitro and in vivo

Antiviral research, 2019-11, Vol.171, p.104592-104592, Article 104592

2019

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Second generation of diazachrysenes: Protection of Ebola virus infected mice and mechanism of action

European journal of medicinal chemistry, 2019-01, Vol.162, p.32-50

2019

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Enhancing the antibacterial activity of polymyxins using a nonantibiotic drug

Infection and drug resistance, 2019-01, Vol.12, p.1393-1405

2019

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Discovery of a novel Kv7 channel opener as a treatment for epilepsy

Bioorganic & medicinal chemistry letters, 2015-11, Vol.25 (21), p.4941-4944

2015

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Discovering Drugs for the Treatment of Ebola Virus

Current treatment options in infectious disease, 2017, Vol.9 (3), p.299-317

2017

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1-[(1-Methyl-1H-imidazol-2-yl)methyl]-4-phenylpiperidines as mGluR2 Positive Allosteric Modulators for the Treatment of Psychosis

Journal of medicinal chemistry, 2011-03, Vol.54 (6), p.1724-1739

2011

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3-Benzyl-1,3-oxazolidin-2-ones as mGluR2 positive allosteric modulators: Hit-to lead and lead optimization

Bioorganic & medicinal chemistry letters, 2009-05, Vol.19 (9), p.2524-2529

2009

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3-(Imidazolyl methyl)-3-aza-bicyclo[3.1.0]hexan-6-yl)methyl ethers: A novel series of mGluR2 positive allosteric modulators

Bioorganic & medicinal chemistry, 2008-10, Vol.18 (20), p.5493-5496

2008

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SAR of a Series of 5,6-Dihydro-(9H)-pyrazolo[3,4-c]-1,2,4-triazolo[4,3-α]pyridines as Potent Inhibitors of Human Eosinophil Phosphodiesterase

Journal of medicinal chemistry, 2007-01, Vol.50 (2), p.344-349

2007

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Discovery, synthesis and SAR of azinyl- and azolylbenzamides antagonists of the P2X7 receptor

Bioorganic & medicinal chemistry letters, 2011-09, Vol.21 (18), p.5475-5479

2011

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Optimization of the physicochemical and pharmacokinetic attributes in a 6-azauracil series of P2X₇ receptor antagonists leading to the discovery of the clinical candidate CE-224,535

Bioorganic & medicinal chemistry letters, 2011-06, Vol.21 (12), p.3708-3711

2011

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Pimaricin. Stereochemistry and synthesis of its aglycon (pimarolide) methyl ester

Journal of the American Chemical Society, 1990-09, Vol.112 (19), p.7079-7081

1990

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Biarylcarboxylic Acids and -amides: Inhibition of Phosphodiesterase Type IV versus [3H]Rolipram Binding Activity and Their Relationship to Emetic Behavior in the Ferret

Journal of medicinal chemistry, 1996-01, Vol.39 (1), p.120-125

1996

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New Steroidal 4-Aminoquinolines Antagonize Botulinum Neurotoxin Serotype A in Mouse Embryonic Stem Cell Derived Motor Neurons in Post-intoxication Model

Journal of medicinal chemistry, 2018-02, Vol.61 (4), p.1595-1608

2018

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Enhancing the antibacterial activity of polymyxins using a nonantibiotic drug

Infection and drug resistance, 2019-05, p.1393

2019

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The Human Cathelicidin Antimicrobial Peptide LL-37 as a Potential Treatment for Polymicrobial Infected Wounds

Mitigating the Impact of Antibacterial Drug Resistance through Host-Directed Therapies: Current Progress, Outlook, and Challenges

Searching for Therapeutics Against Botulinum Neurotoxins: A True Challenge for Drug Discovery

Synthesis of [ 18 F]Favipiravir and Biodistribution in C3H/HeN Mice as Assessed by Positron Emission Tomography

Vinyl Sulfone-Based Inhibitors of Nonstructural Protein 2 Block the Replication of Venezuelan Equine Encephalitis Virus

Discovery, SAR, and Pharmacokinetics of a Novel 3-Hydroxyquinolin-2(1H)-one Series of Potent d-Amino Acid Oxidase (DAAO) Inhibitors

Discovery of 4-(5-Methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (CP-810,123), a Novel α7 Nicotinic Acetylcholine Receptor Agonist for the Treatment of Cognitive Disorders in Schizophrenia: Synthesis, SAR Development, and in Vivo Efficacy in Cognition Models

Modulation of NMDA receptor function by inhibition of d-amino acid oxidase in rodent brain

Recent successes in therapeutics for Ebola virus disease: no time for complacency

Cholesterol-conjugated stapled peptides inhibit Ebola and Marburg viruses in vitro and in vivo

Second generation of diazachrysenes: Protection of Ebola virus infected mice and mechanism of action

Enhancing the antibacterial activity of polymyxins using a nonantibiotic drug

Discovery of 4-(5-methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (CP-810,123), a novel alpha 7 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders in schizophrenia: synthesis, SAR development, and in vivo efficacy in cognition models

Discovery of a novel Kv7 channel opener as a treatment for epilepsy

Discovering Drugs for the Treatment of Ebola Virus

1-[(1-Methyl-1H-imidazol-2-yl)methyl]-4-phenylpiperidines as mGluR2 Positive Allosteric Modulators for the Treatment of Psychosis

3-Benzyl-1,3-oxazolidin-2-ones as mGluR2 positive allosteric modulators: Hit-to lead and lead optimization

3-(Imidazolyl methyl)-3-aza-bicyclo[3.1.0]hexan-6-yl)methyl ethers: A novel series of mGluR2 positive allosteric modulators

SAR of a Series of 5,6-Dihydro-(9H)-pyrazolo[3,4-c]-1,2,4-triazolo[4,3-α]pyridines as Potent Inhibitors of Human Eosinophil Phosphodiesterase

Discovery, synthesis and SAR of azinyl- and azolylbenzamides antagonists of the P2X7 receptor

Optimization of the physicochemical and pharmacokinetic attributes in a 6-azauracil series of P2X₇ receptor antagonists leading to the discovery of the clinical candidate CE-224,535

Pimaricin. Stereochemistry and synthesis of its aglycon (pimarolide) methyl ester

Biarylcarboxylic Acids and -amides: Inhibition of Phosphodiesterase Type IV versus [3H]Rolipram Binding Activity and Their Relationship to Emetic Behavior in the Ferret

New Steroidal 4-Aminoquinolines Antagonize Botulinum Neurotoxin Serotype A in Mouse Embryonic Stem Cell Derived Motor Neurons in Post-intoxication Model

Enhancing the antibacterial activity of polymyxins using a nonantibiotic drug

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