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Central IRAK-4 kinase inhibition for the treatment of pain following nerve injury in rats

Brain, behavior, and immunity, 2020-08, Vol.88, p.781-790

2020

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Fragment-Based Discovery of Novel Potent Sepiapterin Reductase Inhibitors

Journal of medicinal chemistry, 2019-07, Vol.62 (13), p.6391-6397

2019

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Inhibition of TGF-β induced lung fibroblast to myofibroblast conversion by phosphodiesterase inhibiting drugs and activators of soluble guanylyl cyclase

European journal of pharmacology, 2007-10, Vol.572 (1), p.12-22

2007

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Inhibiting the immunoproteasome's β5i catalytic activity affects human peripheral blood‐derived immune cell viability

Pharmacology research & perspectives, 2019-08, Vol.7 (4), p.e00482-n/a

2019

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Characterization of inhibitors of phosphodiesterase 1C on a human cellular system

The FEBS journal, 2007-09, Vol.274 (18), p.4812-4824

2007

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Cytokine-dependent balance of mitogenic effects in primary human lung fibroblasts related to cyclic AMP signaling and phosphodiesterase 4 inhibition

Journal of cellular physiology, 2010-05, Vol.223 (2), p.317-326

2010

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Cell proliferation and DNA breaks are involved in ultraviolet light-induced apoptosis in nucleotide excision repair-deficient Chinese hamster cells

Molecular biology of the cell, 2002-01, Vol.13 (1), p.348-361

2002

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The effect of Sildenafil on human platelet secretory function is controlled by a complex interplay between phosphodiesterases 2, 3 and 5

Cellular signalling, 2005-03, Vol.17 (3), p.331-339

2005

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Phosphodiesterase-5 inhibitors have distinct effects on the hemodynamics of the liver

BMC gastroenterology, 2009-09, Vol.9 (1), p.69-69, Article 69

2009

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Resistance of p53 knockout cells to doxorubicin is related to reduced formation of DNA strand breaks rather than impaired apoptotic signaling

DNA repair, 2003-01, Vol.2 (1), p.49-60

2003

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The differential impact of PDE4 subtypes in human lung fibroblasts on cytokine-induced proliferation and myofibroblast conversion

Journal of cellular physiology, 2011-08, Vol.226 (8), p.1970-1980

2011

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Ionizing radiation but not anticancer drugs causes cell cycle arrest and failure to activate the mitochondrial death pathway in MCF-7 breast carcinoma cells

Oncogene, 2001-08, Vol.20 (36), p.5043-5053

2001

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Phosphodiesterase 1 upregulation in pulmonary arterial hypertension : Target for reverse-remodeling therapy

Circulation (New York, N.Y.), 2007-05, Vol.115 (17), p.2331-2339

2007

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Ultraviolet light-induced DNA damage triggers apoptosis in nucleotide excision repair-deficient cells via Bcl-2 decline and caspase-3/-8 activation

Oncogene, 2001-09, Vol.20 (42), p.6026-6038

2001

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Virtual and experimental high-throughput screening (HTS) in search of novel inosine 5′-monophosphate dehydrogenase II (IMPDH II) inhibitors

Journal of computer-aided molecular design, 2012-11, Vol.26 (11), p.1277-1292

2012

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Design, synthesis and biological evaluation of novel inosine 5′-monophosphate dehydrogenase (IMPDH) inhibitors

Journal of enzyme inhibition and medicinal chemistry, 2014-06, Vol.29 (3), p.408-419

2014

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Apoptosis induced by MNNG in human TK6 lymphoblastoid cells is p53 and Fas/CD95/Apo-1 related

Mutation research, 2003-11, Vol.544 (2), p.167-172

2003

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S1299 Low-Dose Phosphodiesterase-5-Inhibitors Have a Distinct Effect On Hepatic Hemodynamics

Gastroenterology (New York, N.Y. 1943), 2008, Vol.134 (4), p.A-221-A-221

2008

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The GAF-tandem domain of phosphodiesterase 5 as a potential drug target

Handbook of experimental pharmacology, 2011 (204), p.151

2011

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The HMG-CoA reductase inhibitor lovastatin protects cells from the antineoplastic drugs doxorubicin and etoposide

International journal of molecular medicine, 2002-10, Vol.10 (4), p.473

2002

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Quantification of apoptosis induction by doxorubicin in three types of human mammary carcinoma spheroids

Anticancer research, 1999-07, Vol.19 (4B), p.3141

1999

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Differential changes in purine nucleotides after Doxorubicin treatment of human cancer cells in vitro

International journal of oncology, 2002-08, Vol.21 (2), p.289

2002

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Cisplatin-induced apoptosis in 43-3B and 27-1 cells defective in nucleotide excision repair

Mutation research, 2001-09, Vol.486 (4), p.249-258

2001

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Central IRAK-4 kinase inhibition for the treatment of pain following nerve injury in rats

Fragment-Based Discovery of Novel Potent Sepiapterin Reductase Inhibitors

Inhibition of TGF-β induced lung fibroblast to myofibroblast conversion by phosphodiesterase inhibiting drugs and activators of soluble guanylyl cyclase

Template for the description of cell-based toxicological test methods to allow evaluation and regulatory use of the data

Inhibiting the immunoproteasome's β5i catalytic activity affects human peripheral blood‐derived immune cell viability

Characterization of inhibitors of phosphodiesterase 1C on a human cellular system

Cytokine-dependent balance of mitogenic effects in primary human lung fibroblasts related to cyclic AMP signaling and phosphodiesterase 4 inhibition

Cell proliferation and DNA breaks are involved in ultraviolet light-induced apoptosis in nucleotide excision repair-deficient Chinese hamster cells

The effect of Sildenafil on human platelet secretory function is controlled by a complex interplay between phosphodiesterases 2, 3 and 5

Phosphodiesterase-5 inhibitors have distinct effects on the hemodynamics of the liver

Resistance of p53 knockout cells to doxorubicin is related to reduced formation of DNA strand breaks rather than impaired apoptotic signaling

The differential impact of PDE4 subtypes in human lung fibroblasts on cytokine-induced proliferation and myofibroblast conversion

Ionizing radiation but not anticancer drugs causes cell cycle arrest and failure to activate the mitochondrial death pathway in MCF-7 breast carcinoma cells

Phosphodiesterase 1 upregulation in pulmonary arterial hypertension : Target for reverse-remodeling therapy

Ultraviolet light-induced DNA damage triggers apoptosis in nucleotide excision repair-deficient cells via Bcl-2 decline and caspase-3/-8 activation

Virtual and experimental high-throughput screening (HTS) in search of novel inosine 5′-monophosphate dehydrogenase II (IMPDH II) inhibitors

Erratum to Template for the description of cell-based toxicological test methods to allow evaluation and regulatory use of the data

Design, synthesis and biological evaluation of novel inosine 5′-monophosphate dehydrogenase (IMPDH) inhibitors

Apoptosis induced by MNNG in human TK6 lymphoblastoid cells is p53 and Fas/CD95/Apo-1 related

S1299 Low-Dose Phosphodiesterase-5-Inhibitors Have a Distinct Effect On Hepatic Hemodynamics

The GAF-tandem domain of phosphodiesterase 5 as a potential drug target

The HMG-CoA reductase inhibitor lovastatin protects cells from the antineoplastic drugs doxorubicin and etoposide

Quantification of apoptosis induction by doxorubicin in three types of human mammary carcinoma spheroids

Differential changes in purine nucleotides after Doxorubicin treatment of human cancer cells in vitro

Cisplatin-induced apoptosis in 43-3B and 27-1 cells defective in nucleotide excision repair

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