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The role of histamine H1 and H4 receptors in allergic inflammation: the search for new antihistamines

Nature reviews. Drug discovery, 2008-01, Vol.7 (1), p.41-53

2008

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The Histamine H4 Receptor Mediates Inflammation and Pruritus in Th2-Dependent Dermal Inflammation

Journal of investigative dermatology, 2010-04, Vol.130 (4), p.1023-1033

2010

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Histamine H4 receptor antagonists are superior to traditional antihistamines in the attenuation of experimental pruritus

Journal of allergy and clinical immunology, 2007, Vol.119 (1), p.176-183

2007

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The CSF-1-receptor inhibitor, JNJ-40346527 (PRV-6527), reduced inflammatory macrophage recruitment to the intestinal mucosa and suppressed murine T cell mediated colitis

PloS one, 2019-11, Vol.14 (11), p.e0223918-e0223918

2019

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The histamine H4 receptor mediates inflammation and Th17 responses in preclinical models of arthritis

Annals of the rheumatic diseases, 2014-03, Vol.73 (3), p.600-608

2014

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Histamine H4 receptor antagonism diminishes existing airway inflammation and dysfunction via modulation of Th2 cytokines

Respiratory research, 2010-06, Vol.11 (1), p.86-86, Article 86

2010

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A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties

The Journal of pharmacology and experimental therapeutics, 2004-04, Vol.309 (1), p.404

2004

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Clinical Development of Histamine H4 Receptor Antagonists

Histamine and Histamine Receptors in Health and Disease, 2017, Vol.241, p.301-320

2017

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The role of histamine H 1 and H 4 receptors in allergic inflammation: the search for new antihistamines

Nature reviews. Drug discovery, 2008-01, Vol.7 (1), p.41-53

2008

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Inhibitory effects of histamine H4 receptor antagonists on experimental colitis in the rat

European journal of pharmacology, 2005-10, Vol.522 (1-3), p.130-138

2005

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Anti-inflammatory activity of a potent, selective leukotriene A4 hydrolase inhibitor in comparison with the 5-lipoxygenase inhibitor zileuton

The Journal of pharmacology and experimental therapeutics, 2007-06, Vol.321 (3), p.1154

2007

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Antagonism of the histamine H4 receptor reduces LPS-induced TNF production in vivo

Inflammation research, 2013-06, Vol.62 (6), p.599-607

2013

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The histamine H₄ receptor antagonist, JNJ 39758979, is effective in reducing histamine-induced pruritus in a randomized clinical study in healthy subjects

The Journal of pharmacology and experimental therapeutics, 2014-07, Vol.350 (1), p.181

2014

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The histamine H 4 receptor mediates inflammation and Th17 responses in preclinical models of arthritis

Annals of the rheumatic diseases, 2014-03, Vol.73 (3), p.600-608

2014

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The Histamine H4 Receptor Mediates Allergic Airway Inflammation by Regulating the Activation of CD4+ T Cells

The Journal of immunology (1950), 2006-06, Vol.176 (11), p.7062-7070

2006

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The histamine H4 receptor: A novel modulator of inflammatory and immune disorders

Pharmacology & therapeutics (Oxford), 2007-03, Vol.113 (3), p.594-606

2007

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A novel B-RAF inhibitor blocks interleukin-8 (IL-8) synthesis in human melanoma xenografts, revealing IL-8 as a potential pharmacodynamic biomarker

Molecular cancer therapeutics, 2008-03, Vol.7 (3), p.492-499

2008

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Toreforant, an orally active histamine H 4 -receptor antagonist, in patients with active rheumatoid arthritis despite methotrexate: mechanism of action results from a phase 2, multicenter, randomized, double-blind, placebo-controlled synovial biopsy study

Inflammation research, 2019-04, Vol.68 (4), p.261

2019

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Toreforant, an orally active histamine H4-receptor antagonist, in patients with active rheumatoid arthritis despite methotrexate: mechanism of action results from a phase 2, multicenter, randomized, double-blind, placebo-controlled synovial biopsy study

Inflammation research, 2019-04, Vol.68 (4), p.261-274

2019

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Clinical Development of Histamine H 4 Receptor Antagonists

Handbook of experimental pharmacology, 2017, Vol.241, p.301

2017

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Leukotriene A(4) hydrolase inhibition attenuates allergic airway inflammation and hyperresponsiveness

American journal of respiratory and critical care medicine, 2010-05, Vol.181 (9), p.899-907

2010

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Leukotriene A4 Hydrolase Inhibition Attenuates Allergic Airway Inflammation and Hyperresponsiveness

American journal of respiratory and critical care medicine, 2010-05, Vol.181 (9), p.899-907

2010

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Preparation and Biological Evaluation of Indole, Benzimidazole, and Thienopyrrole Piperazine Carboxamides: Potent Human Histamine H4 Antagonists

Journal of medicinal chemistry, 2005-12, Vol.48 (26), p.8289-8298

2005

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Discovery and SAR of 6‑Alkyl-2,4-diaminopyrimidines as Histamine H4 Receptor Antagonists

Journal of medicinal chemistry, 2014-03, Vol.57 (6), p.2429-2439

2014

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The role of histamine in asthma

Advances in experimental medicine and biology, 2010, Vol.709, p.53

2010

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The role of histamine H1 and H4 receptors in allergic inflammation: the search for new antihistamines

The Histamine H4 Receptor Mediates Inflammation and Pruritus in Th2-Dependent Dermal Inflammation

Histamine H4 receptor antagonists are superior to traditional antihistamines in the attenuation of experimental pruritus

The CSF-1-receptor inhibitor, JNJ-40346527 (PRV-6527), reduced inflammatory macrophage recruitment to the intestinal mucosa and suppressed murine T cell mediated colitis

The histamine H4 receptor mediates inflammation and Th17 responses in preclinical models of arthritis

Histamine H4 receptor antagonism diminishes existing airway inflammation and dysfunction via modulation of Th2 cytokines

A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties

Clinical Development of Histamine H4 Receptor Antagonists

The role of histamine H 1 and H 4 receptors in allergic inflammation: the search for new antihistamines

Inhibitory effects of histamine H4 receptor antagonists on experimental colitis in the rat

Anti-inflammatory activity of a potent, selective leukotriene A4 hydrolase inhibitor in comparison with the 5-lipoxygenase inhibitor zileuton

Antagonism of the histamine H4 receptor reduces LPS-induced TNF production in vivo

The histamine H₄ receptor antagonist, JNJ 39758979, is effective in reducing histamine-induced pruritus in a randomized clinical study in healthy subjects

The histamine H 4 receptor mediates inflammation and Th17 responses in preclinical models of arthritis

The Histamine H4 Receptor Mediates Allergic Airway Inflammation by Regulating the Activation of CD4+ T Cells

The histamine H4 receptor: A novel modulator of inflammatory and immune disorders

A novel B-RAF inhibitor blocks interleukin-8 (IL-8) synthesis in human melanoma xenografts, revealing IL-8 as a potential pharmacodynamic biomarker

Toreforant, an orally active histamine H 4 -receptor antagonist, in patients with active rheumatoid arthritis despite methotrexate: mechanism of action results from a phase 2, multicenter, randomized, double-blind, placebo-controlled synovial biopsy study

Toreforant, an orally active histamine H4-receptor antagonist, in patients with active rheumatoid arthritis despite methotrexate: mechanism of action results from a phase 2, multicenter, randomized, double-blind, placebo-controlled synovial biopsy study

Clinical Development of Histamine H 4 Receptor Antagonists

Leukotriene A(4) hydrolase inhibition attenuates allergic airway inflammation and hyperresponsiveness

Leukotriene A4 Hydrolase Inhibition Attenuates Allergic Airway Inflammation and Hyperresponsiveness

Preparation and Biological Evaluation of Indole, Benzimidazole, and Thienopyrrole Piperazine Carboxamides: Potent Human Histamine H4 Antagonists

Discovery and SAR of 6‑Alkyl-2,4-diaminopyrimidines as Histamine H4 Receptor Antagonists

The role of histamine in asthma

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