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The COP9 Signalosome: A Multi-DUB Complex

Biomolecules (Basel, Switzerland), 2020-07, Vol.10 (7), p.1082

2020

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Cullin 3-Based Ubiquitin Ligases as Master Regulators of Mammalian Cell Differentiation

Trends in biochemical sciences (Amsterdam. Regular ed.), 2018-02, Vol.43 (2), p.95-107

2018

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COP9 signalosome function in the DDR

FEBS letters, 2011-09, Vol.585 (18), p.2845-2852

2011

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Latent CSN-CRL complexes are crucial for curcumin-induced apoptosis and recruited during adipogenesis to lipid droplets via small GTPase RAB18

iScience, 2023-04, Vol.26 (4), p.106468-106468, Article 106468

2023

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The COP9 Signalosome Variant CSNCSN7A Stabilizes the Deubiquitylating Enzyme CYLD Impeding Hepatic Steatosis

Livers, 2021-07, Vol.1 (3), p.116-131

2021

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Electron microscopy and in vitro deneddylation reveal similar architectures and biochemistry of isolated human and Flag-mouse COP9 signalosome complexes

Biochemical and biophysical research communications, 2014-07, Vol.450 (2), p.991-997

2014

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Honokiol, a Small Molecular Weight Natural Product, Inhibits Angiogenesis in Vitro and Tumor Growth in Vivo

The Journal of biological chemistry, 2003-09, Vol.278 (37), p.35501-35507

2003

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Control of multicellular development by the physically interacting deneddylases DEN1/DenA and COP9 signalosome

PLoS genetics, 2013-02, Vol.9 (2), p.e1003275-e1003275

2013

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Caspase Activation Inhibits Proteasome Function during Apoptosis

Molecular cell, 2004-04, Vol.14 (1), p.81-93

2004

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The Zinc Finger of the CSN-Associated Deubiquitinating Enzyme USP15 Is Essential to Rescue the E3 Ligase Rbx1

Current biology, 2005-07, Vol.15 (13), p.1217-1221

2005

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The COP9 signalosome: at the interface between signal transduction and ubiquitin-dependent proteolysis

Journal of cell science, 2002-02, Vol.115 (Pt 3), p.467-473

2002

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Integration of Fungus-Specific CandA-C1 into a Trimeric CandA Complex Allowed Splitting of the Gene for the Conserved Receptor Exchange Factor of CullinA E3 Ubiquitin Ligases in Aspergilli

mBio, 2019-06, Vol.10 (3)

2019

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Ubiquitin-dependent Proteolysis of the Microtubule End-binding Protein 1, EB1, Is Controlled by the COP9 Signalosome: Possible Consequences for Microtubule Filament Stability

Journal of molecular biology, 2007-04, Vol.368 (2), p.550-563

2007

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Regulatory subunit interactions of the 26S proteasome, a complex problem

Trends in biochemical sciences (Amsterdam. Regular ed.), 2000-02, Vol.25 (2), p.83-88

2000

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Downregulation of COP9 signalosome subunits differentially affects the CSN complex and target protein stability

BMC biochemistry, 2007-12, Vol.8 (1), p.27-27, Article 27

2007

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Diversity of COP9 signalosome structures and functional consequences

FEBS letters, 2015-09, Vol.589 (19), p.2507-2513

2015

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Resolving the CSN and CAND1 Paradoxes

Molecular cell, 2009-09, Vol.35 (5), p.547-549

Dubiel, Wolfgang

2009

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Gankyrin Is an Ankyrin-repeat Oncoprotein That Interacts with CDK4 Kinase and the S6 ATPase of the 26 S Proteasome

The Journal of biological chemistry, 2002-03, Vol.277 (13), p.10893-10902

2002

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The COP9 signalosome, cullin 3 and Keap1 supercomplex regulates CHOP stability and adipogenesis

Biology open, 2012-08, Vol.1 (8), p.705-710

2012

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Novel curcumin- and emodin-related compounds identified by in silico 2D/3D conformer screening induce apoptosis in tumor cells

BMC cancer, 2005-08, Vol.5 (1), p.97-97, Article 97

2005

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COP9 Signalosome-directed c-Jun Activation/Stabilization Is Independent of JNK

The Journal of biological chemistry, 1999-12, Vol.274 (50), p.35297-35300

1999

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Dual roles of HSP70 chaperone HSPA1 in quality control of nascent and newly synthesized proteins

The EMBO journal, 2021-07, Vol.40 (13), p.e106183-n/a

2021

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Intracellular IL-1 Receptor Antagonist Type 1 Inhibits IL-1-Induced Cytokine Production in Keratinocytes through Binding to the Third Component of the COP9 Signalosome

The Journal of immunology (1950), 2005-03, Vol.174 (6), p.3608-3616

2005

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Cul3 neddylation is crucial for gradual lipid droplet formation during adipogenesis

Biochimica et biophysica acta. Molecular cell research, 2017-08, Vol.1864 (8), p.1405-1412

2017

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CSN7B defines a variant COP9 signalosome complex with distinct function in DNA damage response

Cell reports (Cambridge), 2021-01, Vol.34 (4), p.108662-108662, Article 108662

2021

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The COP9 Signalosome: A Multi-DUB Complex

Cullin 3-Based Ubiquitin Ligases as Master Regulators of Mammalian Cell Differentiation

COP9 signalosome function in the DDR

Latent CSN-CRL complexes are crucial for curcumin-induced apoptosis and recruited during adipogenesis to lipid droplets via small GTPase RAB18

The COP9 Signalosome Variant CSNCSN7A Stabilizes the Deubiquitylating Enzyme CYLD Impeding Hepatic Steatosis

Electron microscopy and in vitro deneddylation reveal similar architectures and biochemistry of isolated human and Flag-mouse COP9 signalosome complexes

Honokiol, a Small Molecular Weight Natural Product, Inhibits Angiogenesis in Vitro and Tumor Growth in Vivo

Control of multicellular development by the physically interacting deneddylases DEN1/DenA and COP9 signalosome

Caspase Activation Inhibits Proteasome Function during Apoptosis

The Zinc Finger of the CSN-Associated Deubiquitinating Enzyme USP15 Is Essential to Rescue the E3 Ligase Rbx1

The COP9 signalosome: at the interface between signal transduction and ubiquitin-dependent proteolysis

Integration of Fungus-Specific CandA-C1 into a Trimeric CandA Complex Allowed Splitting of the Gene for the Conserved Receptor Exchange Factor of CullinA E3 Ubiquitin Ligases in Aspergilli

Ubiquitin-dependent Proteolysis of the Microtubule End-binding Protein 1, EB1, Is Controlled by the COP9 Signalosome: Possible Consequences for Microtubule Filament Stability

Regulatory subunit interactions of the 26S proteasome, a complex problem

Downregulation of COP9 signalosome subunits differentially affects the CSN complex and target protein stability

Diversity of COP9 signalosome structures and functional consequences

Resolving the CSN and CAND1 Paradoxes

Gankyrin Is an Ankyrin-repeat Oncoprotein That Interacts with CDK4 Kinase and the S6 ATPase of the 26 S Proteasome

The COP9 signalosome, cullin 3 and Keap1 supercomplex regulates CHOP stability and adipogenesis

Novel curcumin- and emodin-related compounds identified by in silico 2D/3D conformer screening induce apoptosis in tumor cells

COP9 Signalosome-directed c-Jun Activation/Stabilization Is Independent of JNK

Dual roles of HSP70 chaperone HSPA1 in quality control of nascent and newly synthesized proteins

Intracellular IL-1 Receptor Antagonist Type 1 Inhibits IL-1-Induced Cytokine Production in Keratinocytes through Binding to the Third Component of the COP9 Signalosome

Cul3 neddylation is crucial for gradual lipid droplet formation during adipogenesis

CSN7B defines a variant COP9 signalosome complex with distinct function in DNA damage response

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