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Synthesis and evaluation of hybrid molecules as RIPK1 and HDACs dual inhibitors

Journal of molecular structure, 2024-12, Vol.1318, p.139238, Article 139238

2024

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Macrophages-mediated tumor accumulation and deep penetration of bismuth/manganese biomineralized nanoparticles for enhanced radiotherapy

Chinese chemical letters, 2024-12, Vol.35 (12), p.109632, Article 109632

2024

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Design, synthesis, and structure–activity relationship studies of 6,7-dihydro-5H-pyrrolo[1,2-b][1,2,4]triazole derivatives as necroptosis inhibitors

RSC medicinal chemistry, 2024-07, Vol.15 (7), p.2514-2526

2024

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Design, synthesis, and structure-activity relationship studies of 6,7-dihydro-5H-pyrrolo1,2-b1,2,4triazole derivatives as necroptosis inhibitors

RSC medicinal chemistry, 2024-07, Vol.15 (7), p.2514

2024

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Design, synthesis, and structure-activity relationship studies of 6,7-dihydro-5-pyrrolo[1,2-][1,2,4]triazole derivatives as necroptosis inhibitors

RSC medicinal chemistry, 2024-07, Vol.15 (7), p.2514-2526

2024

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Design, synthesis, and structure–activity relationship studies of 6,7-dihydro-5 H -pyrrolo[1,2- b ][1,2,4]triazole derivatives as necroptosis inhibitors

RSC medicinal chemistry, 2024-07, Vol.15 (7), p.2514-2526

2024

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Discovery and optimization of 3‐(indolin‐5‐yloxy)pyridin‐2‐amine derivatives as potent necroptosis inhibitors

Archiv der Pharmazie (Weinheim), 2024-07, p.e2400302

2024

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Design, synthesis, and evaluation of thiazolecarboxamide derivatives as stimulator of interferon gene inhibitors

Molecular diversity, 2024-04

2024

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A Novel IRAK4 Inhibitor DW18134 Ameliorates Peritonitis and Inflammatory Bowel Disease

Molecules (Basel, Switzerland), 2024-04, Vol.29 (8), p.1803

2024

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A novel strategy for treating oncogene‐mutated tumors by targeting tumor microenvironment and synergistically enhancing anti‐PD‐1 immunotherapy

Cancer communications (London, England), 2024-03, Vol.44 (3), p.438-442

2024

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Discovery of a 1,6-naphthyridin-4-one-based AXL inhibitor with improved pharmacokinetics and enhanced in vivo antitumor efficacy

European journal of medicinal chemistry, 2024-02, Vol.265, p.116045-116045, Article 116045

2024

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Discovery of hematopoietic progenitor kinase 1 inhibitors using machine learning-based screening and free energy perturbation

Journal of biomolecular structure & dynamics, 2024-01, p.1-13

2024

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Pathogenesis and comprehensive treatment strategies of sarcopenia in elderly patients with type 2 diabetes mellitus

Frontiers in endocrinology (Lausanne), 2024-01, Vol.14, p.1263650-1263650

2024

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Multitarget therapy with a corticosteroid, cyclosporine and mycophenolate mofetil for idiopathic membranous nephropathy: a prospective randomized controlled trial

Nephrology, dialysis, transplantation, 2023-12, Vol.39 (1), p.95-102

2023

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Preclinical and early clinical studies of a novel compound SYHA1813 that efficiently crosses the blood–brain barrier and exhibits potent activity against glioblastoma

Acta pharmaceutica Sinica. B, 2023-12, Vol.13 (12), p.4748-4764

2023

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Design, synthesis, and STING-agonistic activity of benzo[b]thiophene-2-carboxamide derivatives

Molecular diversity, 2023-10

2023

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Design, synthesis and pharmacological evaluation of 2,3-dihydrobenzofuran IRAK4 inhibitors for the treatment of diffuse large B-cell lymphoma

European journal of medicinal chemistry, 2023-08, Vol.256, p.115453-115453, Article 115453

2023

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A depth map fusion algorithm with improved efficiency considering pixel region prediction

ISPRS journal of photogrammetry and remote sensing, 2023-08, Vol.202, p.356-368

2023

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Comparative study of four displacer phase-shifters in a split pulse tube refrigerator working at 170 K

Applied thermal engineering, 2023-07, Vol.230, p.120772, Article 120772

2023

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Discovery of 10 H -Benzo[ b ]pyrido[2,3- e ][1,4]oxazine AXL Inhibitors via Structure-Based Drug Design Targeting c-Met Kinase

Journal of medicinal chemistry, 2023-01, Vol.66 (1), p.220-234

2023

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Discovery of 10H‑Benzo[b]pyrido[2,3‑e][1,4]oxazine AXL Inhibitors via Structure-Based Drug Design Targeting c‑Met Kinase

Journal of medicinal chemistry, 2023-01, Vol.66 (1), p.220-234

2023

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Experimental study of ethane pulsating heat pipe with varying evaporator lengths based on pulse tube refrigerator

International journal of refrigeration, 2023-01, Vol.145, p.40-49

2023

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Structural insights into a shared mechanism of human STING activation by a potent agonist and an autoimmune disease-associated mutation

Cell discovery, 2022-12, Vol.8 (1), p.133-133, Article 133

2022

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Endoplasmic reticulum stress mediates parathyroid hormone-induced apoptosis in vascular smooth muscle cells

Renal failure, 2022-12, Vol.44 (1), p.126-136

2022

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Numerical investigation of a displacer-type pulse tube refrigerator with work recovery

HVAC&R research, 2022-10, Vol.28 (10), p.1341-1354

2022

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Synthesis and evaluation of hybrid molecules as RIPK1 and HDACs dual inhibitors

Macrophages-mediated tumor accumulation and deep penetration of bismuth/manganese biomineralized nanoparticles for enhanced radiotherapy

Design, synthesis, and structure–activity relationship studies of 6,7-dihydro-5H-pyrrolo[1,2-b][1,2,4]triazole derivatives as necroptosis inhibitors

Design, synthesis, and structure-activity relationship studies of 6,7-dihydro-5H-pyrrolo1,2-b1,2,4triazole derivatives as necroptosis inhibitors

Design, synthesis, and structure-activity relationship studies of 6,7-dihydro-5-pyrrolo[1,2-][1,2,4]triazole derivatives as necroptosis inhibitors

Design, synthesis, and structure–activity relationship studies of 6,7-dihydro-5 H -pyrrolo[1,2- b ][1,2,4]triazole derivatives as necroptosis inhibitors

Discovery and optimization of 3‐(indolin‐5‐yloxy)pyridin‐2‐amine derivatives as potent necroptosis inhibitors

Design, synthesis, and evaluation of thiazolecarboxamide derivatives as stimulator of interferon gene inhibitors

A Novel IRAK4 Inhibitor DW18134 Ameliorates Peritonitis and Inflammatory Bowel Disease

A novel strategy for treating oncogene‐mutated tumors by targeting tumor microenvironment and synergistically enhancing anti‐PD‐1 immunotherapy

Discovery of a 1,6-naphthyridin-4-one-based AXL inhibitor with improved pharmacokinetics and enhanced in vivo antitumor efficacy

Discovery of hematopoietic progenitor kinase 1 inhibitors using machine learning-based screening and free energy perturbation

Pathogenesis and comprehensive treatment strategies of sarcopenia in elderly patients with type 2 diabetes mellitus

Multitarget therapy with a corticosteroid, cyclosporine and mycophenolate mofetil for idiopathic membranous nephropathy: a prospective randomized controlled trial

Preclinical and early clinical studies of a novel compound SYHA1813 that efficiently crosses the blood–brain barrier and exhibits potent activity against glioblastoma

Design, synthesis, and STING-agonistic activity of benzo[b]thiophene-2-carboxamide derivatives

Design, synthesis and pharmacological evaluation of 2,3-dihydrobenzofuran IRAK4 inhibitors for the treatment of diffuse large B-cell lymphoma

A depth map fusion algorithm with improved efficiency considering pixel region prediction

Comparative study of four displacer phase-shifters in a split pulse tube refrigerator working at 170 K

Discovery of 10 H -Benzo[ b ]pyrido[2,3- e ][1,4]oxazine AXL Inhibitors via Structure-Based Drug Design Targeting c-Met Kinase

Discovery of 10H‑Benzo[b]pyrido[2,3‑e][1,4]oxazine AXL Inhibitors via Structure-Based Drug Design Targeting c‑Met Kinase

Experimental study of ethane pulsating heat pipe with varying evaporator lengths based on pulse tube refrigerator

Structural insights into a shared mechanism of human STING activation by a potent agonist and an autoimmune disease-associated mutation

Endoplasmic reticulum stress mediates parathyroid hormone-induced apoptosis in vascular smooth muscle cells

Numerical investigation of a displacer-type pulse tube refrigerator with work recovery

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