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Turning the spotlight on the C11-oxy androgens in human fetal development

The Journal of steroid biochemistry and molecular biology, 2021-09, Vol.212, p.105946-105946, Article 105946

2021

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Steroid hormone analysis of adolescents and young women with polycystic ovarian syndrome and adrenocortical dysfunction using UPC2-MS/MS

Pediatric research, 2021-01, Vol.89 (1), p.118-126

2021

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No extra-adrenal aldosterone production in various human cell lines

Journal of molecular endocrinology, 2024-04, Vol.72 (3)

2024

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Circulating adrenal and gonadal steroid hormones heterogeneity in active young males and the contribution of 11-oxy androgens

Scientific reports, 2024-07, Vol.14 (1), p.16226-11, Article 16226

2024

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The 11β-hydroxysteroid dehydrogenase isoforms: pivotal catalytic activities yield potent C11-oxy C19 steroids with 11βHSD2 favouring 11-ketotestosterone, 11-ketoandrostenedione and 11-ketoprogesterone biosynthesis

The Journal of steroid biochemistry and molecular biology, 2019-05, Vol.189, p.116-126

2019

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Falsely elevated plasma testosterone concentrations in neonates: importance of LC-MS/MS measurements

Clinical chemistry and laboratory medicine, 2018-05, Vol.56 (6), p.e141

2018

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Effect of Essential Oil Components on the Activity of Steroidogenic Cytochrome P450

Biomolecules (Basel, Switzerland), 2024-02, Vol.14 (2), p.203

2024

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Exploring the Potential of Sulfur Moieties in Compounds Inhibiting Steroidogenesis

Biomolecules (Basel, Switzerland), 2023-09, Vol.13 (9), p.1349

2023

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Basics of androgen synthesis and action

Baillière's best practice & research. Clinical endocrinology & metabolism, 2022-07, Vol.36 (4), p.101665, Article 101665

2022

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Characterising The 11β‐hydroxyandrostenedione‐pathway in In Vitro Models

The FASEB journal, 2020-04, Vol.34 (S1), p.1-1

2020

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Parallel targeted and non-targeted quantitative analysis of steroids in human serum and peritoneal fluid by liquid chromatography high-resolution mass spectrometry

Analytical and bioanalytical chemistry, 2022-10, Vol.414 (25), p.7461-7472

2022

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Back where it belongs: 11β-hydroxyandrostenedione compels the re-assessment of C11-oxy androgens in steroidogenesis

Molecular and cellular endocrinology, 2021-04, Vol.525, p.111189-111189, Article 111189

2021

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The 11β-hydroxyandrostenedione pathway and C11-oxy C21 backdoor pathway are active in benign prostatic hyperplasia yielding 11keto-testosterone and 11keto-progesterone

The Journal of steroid biochemistry and molecular biology, 2020-02, Vol.196, p.105497-105497, Article 105497

2020

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Development and function of the fetal adrenal

Reviews in endocrine & metabolic disorders, 2023-02, Vol.24 (1), p.5-21

2023

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Exploring steroid dynamics in pregnancy - Insights from the maternal-placental-fetal interface and placental models

Placenta (Eastbourne), 2024-09, Vol.154, p.e21

2024

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The 11β-hydroxysteroid dehydrogenase isoforms: pivotal catalytic activities yield potent C11-oxy C 19 steroids with 11βHSD2 favouring 11-ketotestosterone, 11-ketoandrostenedione and 11-ketoprogesterone biosynthesis

The Journal of steroid biochemistry and molecular biology, 2019-05, Vol.189, p.116

2019

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The serum steroid signature of PCOS hints at the involvement of novel pathways for excess androgen biosynthesis

The Journal of steroid biochemistry and molecular biology, 2023-10, Vol.233, p.106366-106366, Article 106366

2023

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CYP11B and CYP17A1 in the Biosynthesis and Metabolism of C11‐oxy Steroids

The FASEB journal, 2020-04, Vol.34 (S1), p.1-1

2020

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Adrenal Abcg1 Controls Cholesterol Flux and Steroidogenesis

Endocrinology (Philadelphia), 2024-01, Vol.165 (3)

2024

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Profiling of steroid hormone species in ex-vivo and in-vitro human placental models

Placenta (Eastbourne), 2023-09, Vol.140, p.e23

2023

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Multiple androgen pathways contribute to the steroid signature of adrenarche

Molecular and cellular endocrinology, 2024-10, Vol.592, p.112293, Article 112293

2024

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Inefficient UGT-conjugation of adrenal 11β-hydroxyandrostenedione metabolites highlights C11-oxy C19 steroids as the predominant androgens in prostate cancer

Molecular and cellular endocrinology, 2018-02, Vol.461, p.265-276

2018

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11α-Hydroxyprogesterone, a potent 11β-hydroxysteroid dehydrogenase inhibitor, is metabolised by steroid-5α-reductase and cytochrome P450 17α-hydroxylase/17,20-lyase to produce C11α-derivatives of 21-deoxycortisol and 11-hydroxyandrostenedione in vitro

The Journal of steroid biochemistry and molecular biology, 2019-07, Vol.191, p.105369-105369, Article 105369

2019

Volltextzugriff (PDF)

SAT-742 Characterising the Metabolism, Glucuronidation and Sulfation of C11-oxy C19 Steroids

Journal of the Endocrine Society, 2020-05, Vol.4 (Supplement_1)

2020

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Advances in the analytical methodologies: Profiling steroids in familiar pathways-challenging dogmas

The Journal of steroid biochemistry and molecular biology, 2015-09, Vol.153, p.80-92

2015

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Turning the spotlight on the C11-oxy androgens in human fetal development

Steroid hormone analysis of adolescents and young women with polycystic ovarian syndrome and adrenocortical dysfunction using UPC2-MS/MS

No extra-adrenal aldosterone production in various human cell lines

Circulating adrenal and gonadal steroid hormones heterogeneity in active young males and the contribution of 11-oxy androgens

The 11β-hydroxysteroid dehydrogenase isoforms: pivotal catalytic activities yield potent C11-oxy C19 steroids with 11βHSD2 favouring 11-ketotestosterone, 11-ketoandrostenedione and 11-ketoprogesterone biosynthesis

Falsely elevated plasma testosterone concentrations in neonates: importance of LC-MS/MS measurements

Effect of Essential Oil Components on the Activity of Steroidogenic Cytochrome P450

Exploring the Potential of Sulfur Moieties in Compounds Inhibiting Steroidogenesis

Basics of androgen synthesis and action

Characterising The 11β‐hydroxyandrostenedione‐pathway in In Vitro Models

Parallel targeted and non-targeted quantitative analysis of steroids in human serum and peritoneal fluid by liquid chromatography high-resolution mass spectrometry

Back where it belongs: 11β-hydroxyandrostenedione compels the re-assessment of C11-oxy androgens in steroidogenesis

The 11β-hydroxyandrostenedione pathway and C11-oxy C21 backdoor pathway are active in benign prostatic hyperplasia yielding 11keto-testosterone and 11keto-progesterone

Development and function of the fetal adrenal

Exploring steroid dynamics in pregnancy - Insights from the maternal-placental-fetal interface and placental models

The 11β-hydroxysteroid dehydrogenase isoforms: pivotal catalytic activities yield potent C11-oxy C 19 steroids with 11βHSD2 favouring 11-ketotestosterone, 11-ketoandrostenedione and 11-ketoprogesterone biosynthesis

The serum steroid signature of PCOS hints at the involvement of novel pathways for excess androgen biosynthesis

CYP11B and CYP17A1 in the Biosynthesis and Metabolism of C11‐oxy Steroids

Adrenal Abcg1 Controls Cholesterol Flux and Steroidogenesis

Profiling of steroid hormone species in ex-vivo and in-vitro human placental models

Multiple androgen pathways contribute to the steroid signature of adrenarche

Inefficient UGT-conjugation of adrenal 11β-hydroxyandrostenedione metabolites highlights C11-oxy C19 steroids as the predominant androgens in prostate cancer

11α-Hydroxyprogesterone, a potent 11β-hydroxysteroid dehydrogenase inhibitor, is metabolised by steroid-5α-reductase and cytochrome P450 17α-hydroxylase/17,20-lyase to produce C11α-derivatives of 21-deoxycortisol and 11-hydroxyandrostenedione in vitro

SAT-742 Characterising the Metabolism, Glucuronidation and Sulfation of C11-oxy C19 Steroids

Advances in the analytical methodologies: Profiling steroids in familiar pathways-challenging dogmas

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