UB Paderborn / Katalog / Suche / in CDI

Sortiert nach

Einfacher Volltextzugriff von (fast) überall

Installieren Sie die LibKey Nomad-Browsererweiterung und erhalten Sie von vielen Webseiten einfachen Zugriff auf lizenzierte Volltexte oder Open Access Publikationen. Mehr erfahren...

Discovery and development of pyrazole-scaffold Hsp90 inhibitors

Current topics in medicinal chemistry, 2006-06, Vol.6 (11), p.1193-1203

2006

Volltextzugriff (PDF)

novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells

Cancer chemotherapy and pharmacology, 2010-08, Vol.66 (3), p.535-545

2010

Volltextzugriff (PDF)

NVP-AUY922: a small molecule HSP90 inhibitor with potent antitumor activity in preclinical breast cancer models

Breast cancer research : BCR, 2008-01, Vol.10 (2), p.R33-R33, Article R33

2008

Volltextzugriff (PDF)

Discovery of a First-in-Class Inhibitor of the PRMT5–Substrate Adaptor Interaction

Journal of medicinal chemistry, 2021-08, Vol.64 (15), p.11148-11168

2021

Volltextzugriff (PDF)

The SeeDs approach: integrating fragments into drug discovery

Current topics in medicinal chemistry, 2007-08, Vol.7 (16), p.1568-1581

2007

Volltextzugriff (PDF)

Medicinal chemistry of Hsp90 inhibitors

Current topics in medicinal chemistry, 2008-07, Vol.8 (10), p.859-868

2008

Volltextzugriff (PDF)

Novel, Potent Small-Molecule Inhibitors of the Molecular Chaperone Hsp90 Discovered through Structure-Based Design

Journal of medicinal chemistry, 2005-06, Vol.48 (13), p.4212-4215

2005

Volltextzugriff (PDF)

Colorectal Tumors Require NUAK1 for Protection from Oxidative Stress

Cancer discovery, 2018-05, Vol.8 (5), p.632-647

2018

Volltextzugriff (PDF)

Novel Adenosine-Derived Inhibitors of 70 kDa Heat Shock Protein, Discovered Through Structure-Based Design

Journal of medicinal chemistry, 2009-03, Vol.52 (6), p.1510-1513

2009

Volltextzugriff (PDF)

Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer

Cancer research (Chicago, Ill.), 2018-04, Vol.78 (8), p.2096-2114

2018

Volltextzugriff (PDF)

Adenosine-Derived Inhibitors of 78 kDa Glucose Regulated Protein (Grp78) ATPase: Insights into Isoform Selectivity

Journal of medicinal chemistry, 2011-06, Vol.54 (12), p.4034-4041

2011

Volltextzugriff (PDF)

Targeting conserved water molecules: Design of 4-aryl-5-cyanopyrrolo[2,3-d]pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization

Bioorganic & medicinal chemistry, 2012-11, Vol.20 (22), p.6770-6789

2012

Volltextzugriff (PDF)

Preclinical antitumor activity of the orally available heat shock protein 90 inhibitor NVP-BEP800

Molecular cancer therapeutics, 2010-04, Vol.9 (4), p.906-919

2010

Volltextzugriff (PDF)

Identification of a Selective G1-Phase Benzimidazolone Inhibitor by a Senescence-Targeted Virtual Screen Using Artificial Neural Networks

Neoplasia (New York, N.Y.), 2015-09, Vol.17 (9), p.704-715

2015

Volltextzugriff (PDF)

Structure-based Drug Design Targeting an Inactive RNA Conformation: Exploiting the Flexibility of HIV-1 TAR RNA

Journal of molecular biology, 2004-02, Vol.336 (3), p.625-638

2004

Volltextzugriff (PDF)

Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues

Molecular cancer therapeutics, 2007-04, Vol.6 (4), p.1198-1211

2007

Volltextzugriff (PDF)

3-(5-chloro-2,4-dihydroxyphenyl)-Pyrazole-4-carboxamides as inhibitors of the Hsp90 molecular chaperone

Bioorganic & medicinal chemistry letters, 2005-12, Vol.15 (23), p.5197-5201

2005

Volltextzugriff (PDF)

4-Amino derivatives of the Hsp90 inhibitor CCT018159

Bioorganic & medicinal chemistry letters, 2006-05, Vol.16 (9), p.2543-2548

2006

Volltextzugriff (PDF)

Preclinical pharmacokinetics and metabolism of a novel diaryl pyrazole resorcinol series of heat shock protein 90 inhibitors

Molecular cancer therapeutics, 2006-06, Vol.5 (6), p.1628-1637

2006

Volltextzugriff (PDF)

Discovery of a potent CDK2 inhibitor with a novel binding mode, using virtual screening and initial, structure-guided lead scoping

Bioorganic & medicinal chemistry letters, 2007-07, Vol.17 (14), p.3880-3885

2007

Volltextzugriff (PDF)

Adenine derived inhibitors of the molecular chaperone HSP90—SAR explained through multiple X-ray structures

Bioorganic & medicinal chemistry letters, 2004, Vol.14 (2), p.325-328

2004

Volltextzugriff (PDF)

Inhibitors of HSP90 and other chaperones for the treatment of cancer

Expert opinion on therapeutic patents, 2004-06, Vol.14 (6), p.837-847

2004

Volltextzugriff (PDF)

Fragment-based hit identification: thinking in 3D

Drug discovery today, 2013-12, Vol.18 (23-24), p.1221-1227

2013

Volltextzugriff (PDF)

Fragment-based Drug Discovery: the Shape of Things to Come

Australian journal of chemistry, 2013, Vol.66 (12), p.1544

Drysdale, Martin J.

2013

Volltextzugriff (PDF)

1 – 25 von 125

Suche als RSS-Feed

Suchergebnisse filtern

Filter anzeigen

Nur zeigen

Geprüft (Peer-Review)
(101)
Mit Volltextzugriff
(104)

Publikationsform

Sprache

Englisch
(125)
Japanisch
(15)

Erscheinungsjahr

n.n

Thema

Science & Technology
(78)
Life Sciences & Biomedicine
(59)
Humans
(48)
Pharmacology & Pharmacy
(25)
Chemistry
(24)
Physical Sciences
(23)
Chemistry, Medicinal
(21)
Animals
(19)
Biological And Medical Sciences
(17)
Hsp90 Heat-Shock Proteins - Antagonists & Inhibitors
(17)
Medical Sciences
(17)
Structure-Activity Relationship
(17)
Chemistry, Organic
(16)
Pharmacology. Drug Treatments
(16)
Drug Design
(14)
Mice
(14)
Female
(12)
Molecular Structure
(11)
Oncology
(11)
Antineoplastic Agents
(10)

15 weitere anzeigen...

Weniger anzeigen...

Menü

Weitere Dienste

Einstellungen

Discovery and development of pyrazole-scaffold Hsp90 inhibitors

novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells

NVP-AUY922: a small molecule HSP90 inhibitor with potent antitumor activity in preclinical breast cancer models

Discovery of a First-in-Class Inhibitor of the PRMT5–Substrate Adaptor Interaction

The SeeDs approach: integrating fragments into drug discovery

Medicinal chemistry of Hsp90 inhibitors

Novel, Potent Small-Molecule Inhibitors of the Molecular Chaperone Hsp90 Discovered through Structure-Based Design

Colorectal Tumors Require NUAK1 for Protection from Oxidative Stress

Novel Adenosine-Derived Inhibitors of 70 kDa Heat Shock Protein, Discovered Through Structure-Based Design

Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer

Adenosine-Derived Inhibitors of 78 kDa Glucose Regulated Protein (Grp78) ATPase: Insights into Isoform Selectivity

Targeting conserved water molecules: Design of 4-aryl-5-cyanopyrrolo[2,3-d]pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization

Preclinical antitumor activity of the orally available heat shock protein 90 inhibitor NVP-BEP800

4,5-Diarylisoxazole Hsp90 Chaperone Inhibitors: Potential Therapeutic Agents for the Treatment of Cancer

Identification of a Selective G1-Phase Benzimidazolone Inhibitor by a Senescence-Targeted Virtual Screen Using Artificial Neural Networks

Structure-based Drug Design Targeting an Inactive RNA Conformation: Exploiting the Flexibility of HIV-1 TAR RNA

Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues

3-(5-chloro-2,4-dihydroxyphenyl)-Pyrazole-4-carboxamides as inhibitors of the Hsp90 molecular chaperone

4-Amino derivatives of the Hsp90 inhibitor CCT018159

Preclinical pharmacokinetics and metabolism of a novel diaryl pyrazole resorcinol series of heat shock protein 90 inhibitors

Discovery of a potent CDK2 inhibitor with a novel binding mode, using virtual screening and initial, structure-guided lead scoping

Adenine derived inhibitors of the molecular chaperone HSP90—SAR explained through multiple X-ray structures

Inhibitors of HSP90 and other chaperones for the treatment of cancer

Fragment-based hit identification: thinking in 3D

Fragment-based Drug Discovery: the Shape of Things to Come

Suchergebnisse filtern