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Activity of the clinical-stage CK2-specific inhibitor CX-4945 against chronic lymphocytic leukemia

Leukemia, 2014-01, Vol.28 (1), p.179-182

2014

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771: Targeting MYC-driven growth and proliferation in prostate cancer

European journal of cancer (1990), 2014-07, Vol.50, p.S185-S185

2014

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The dual inhibition of RNA Pol I transcription and PIM kinase as a new therapeutic approach to treat advanced prostate cancer

European journal of cancer (1990), 2016-07, Vol.61, p.S167-S167

2016

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The RNA Polymerase I Transcription Machinery: An Emerging Target for the Treatment of Cancer

Annual review of pharmacology and toxicology, 2010-02, Vol.50 (1), p.131-156

2010

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Ribosome biogenesis during cell cycle arrest fuels EMT in development and disease

Nature communications, 2019-05, Vol.10 (1), p.2110-16, Article 2110

2019

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707: Multi-point targeting of the synthetic lethal interactions between Myc, ribosome biogenesis and ribosome function cooperates to treat B-cell lymphoma

European journal of cancer (1990), 2014-07, Vol.50, p.S170-S171

2014

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70: Proffered Paper: Inhibition of RNA Polymerase I transcription by CX-5461 as a completely new approach to treat highly refractory haematological malignancies

European journal of cancer (1990), 2014-07, Vol.50, p.S17-S17

2014

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Sequence-dependent cytotoxicity of second-generation oligonucleotides

Nucleic acids research, 2004-01, Vol.32 (22), p.6585

2004

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Magnesium ions mediate contacts between phosphoryl oxygens at positions 2122 and 2176 of the 23S rRNA and ribosomal protein L1

RNA (Cambridge), 2000-12, Vol.6 (12), p.1714-1726, Article S1355838200001436

2000

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633 The contribution of dysregulated ribosomal gene transcription to malignant transformation

European journal of cancer supplements, 2010, Vol.8 (5), p.160-161

2010

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741 - The dual inhibition of RNA Pol I transcription and PIM kinase as a new therapeutic approach to treat advanced prostate cancer

European journal of cancer (1990), 2016-07, Vol.61, p.S167-S167

2016

Volltextzugriff (PDF)

99 Combined inhibition of EGFR and protein kinase CK2 synergistically blocks phosphorylation of ribosomal protein S6, induces apoptosis in cancer cells and displays enhanced antitumor activity in xenograft models

European journal of cancer supplements, 2010, Vol.8 (7), p.39-39

2010

Volltextzugriff (PDF)

518 CX-4945, an inhibitor of protein kinase CK2, disrupts DNA damage repair, potentiates apoptosis and enhances antitumor activity of gemcitabine in a model of ovarian cancer

European journal of cancer supplements, 2010, Vol.8 (7), p.165-166

2010

Volltextzugriff (PDF)

341 POSTER CX-5461, a novel, orally bioavailable selective small molecule inhibitor of RNA polymerase I transcription, induces autophagy and shows potent antitumor activity

European journal of cancer supplements, 2008, Vol.6 (12), p.108-108

2008

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Structure of the L1 protuberance in the ribosome

Nature structural & molecular biology, 2003-02, Vol.10 (2), p.104-108

2003

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Effect of CX-4945, a selective bioavailable small molecule inhibitor of protein kinase CK2, on gemcitabine antitumor activity in A2780 ovarian cancer

Journal of clinical oncology, 2010-05, Vol.28 (15_suppl), p.e13522-e13522

2010

Volltextzugriff (PDF)

An extremely high conservation of RNA‐protein S7 interactions during prokaryotic ribosomal biogenesis

Biochemistry and molecular biology international, 1998-05, Vol.44 (6), p.1141-1146

1998

Volltextzugriff (PDF)

Induction of Toll-like Receptors and NALP/PAN/PYPAF Family Members by Modified Oligonucleotides in Lung Epithelial Carcinoma Cells

Oligonucleotides, 2005-01, Vol.15 (2), p.15-118

2005

Volltextzugriff (PDF)

Inhibition of RNA Polymerase I as a Therapeutic Strategy to Promote Cancer-Specific Activation of p53

Cancer cell, 2012-07, Vol.22 (1), p.51-65

2012

Volltextzugriff (PDF)

The Dual Inhibition of RNA Pol I Transcription and PIM Kinase as a New Therapeutic Approach to Treat Advanced Prostate Cancer

Clinical cancer research, 2016-11, Vol.22 (22), p.5539-5552

2016

Volltextzugriff (PDF)

Combination Therapy Targeting Ribosome Biogenesis and mRNA Translation Synergistically Extends Survival in MYC-Driven Lymphoma

Cancer discovery, 2016-01, Vol.6 (1), p.59-70

2016

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Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling

Oncotarget, 2016-08, Vol.7 (31), p.49800-49818

2016

Volltextzugriff (PDF)

Choosing and Explaining Methods of Non-Destructive Control of Gear Mechanisms in Imported Excavators

E3S web of conferences, 2020-01, Vol.174, p.3019

2020

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The therapeutic potential of RNA Polymerase I transcription inhibitor, CX-5461, in uterine leiomyosarcoma

Investigational new drugs, 2022-06, Vol.40 (3), p.529-536

2022

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Activity of the clinical-stage CK2-specific inhibitor CX-4945 against chronic lymphocytic leukemia

771: Targeting MYC-driven growth and proliferation in prostate cancer

The dual inhibition of RNA Pol I transcription and PIM kinase as a new therapeutic approach to treat advanced prostate cancer

The RNA Polymerase I Transcription Machinery: An Emerging Target for the Treatment of Cancer

Ribosome biogenesis during cell cycle arrest fuels EMT in development and disease

707: Multi-point targeting of the synthetic lethal interactions between Myc, ribosome biogenesis and ribosome function cooperates to treat B-cell lymphoma

70: Proffered Paper: Inhibition of RNA Polymerase I transcription by CX-5461 as a completely new approach to treat highly refractory haematological malignancies

Sequence-dependent cytotoxicity of second-generation oligonucleotides

Magnesium ions mediate contacts between phosphoryl oxygens at positions 2122 and 2176 of the 23S rRNA and ribosomal protein L1

633 The contribution of dysregulated ribosomal gene transcription to malignant transformation

741 - The dual inhibition of RNA Pol I transcription and PIM kinase as a new therapeutic approach to treat advanced prostate cancer

99 Combined inhibition of EGFR and protein kinase CK2 synergistically blocks phosphorylation of ribosomal protein S6, induces apoptosis in cancer cells and displays enhanced antitumor activity in xenograft models

518 CX-4945, an inhibitor of protein kinase CK2, disrupts DNA damage repair, potentiates apoptosis and enhances antitumor activity of gemcitabine in a model of ovarian cancer

341 POSTER CX-5461, a novel, orally bioavailable selective small molecule inhibitor of RNA polymerase I transcription, induces autophagy and shows potent antitumor activity

Structure of the L1 protuberance in the ribosome

Effect of CX-4945, a selective bioavailable small molecule inhibitor of protein kinase CK2, on gemcitabine antitumor activity in A2780 ovarian cancer

An extremely high conservation of RNA‐protein S7 interactions during prokaryotic ribosomal biogenesis

Induction of Toll-like Receptors and NALP/PAN/PYPAF Family Members by Modified Oligonucleotides in Lung Epithelial Carcinoma Cells

Inhibition of RNA Polymerase I as a Therapeutic Strategy to Promote Cancer-Specific Activation of p53

The Dual Inhibition of RNA Pol I Transcription and PIM Kinase as a New Therapeutic Approach to Treat Advanced Prostate Cancer

Combination Therapy Targeting Ribosome Biogenesis and mRNA Translation Synergistically Extends Survival in MYC-Driven Lymphoma

Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population

Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling

Choosing and Explaining Methods of Non-Destructive Control of Gear Mechanisms in Imported Excavators

The therapeutic potential of RNA Polymerase I transcription inhibitor, CX-5461, in uterine leiomyosarcoma

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