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Prevalence of Acid-Reducing Agents (ARA) in Cancer Populations and ARA Drug–Drug Interaction Potential for Molecular Targeted Agents in Clinical Development

Molecular pharmaceutics, 2013-11, Vol.10 (11), p.4055-4062

2013

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A Guide to Rational Dosing of Monoclonal Antibodies

Clinical pharmacokinetics, 2012-02, Vol.51 (2), p.119-135

2012

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Best practices for the use of itraconazole as a replacement for ketoconazole in drug-drug interaction studies

Journal of clinical pharmacology, 2016-02, Vol.56 (2), p.143-151

2016

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Integrating real‐world data to accelerate and guide drug development: A clinical pharmacology perspective

Clinical and translational science, 2022-10, Vol.15 (10), p.2293-2302

2022

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Evaluation of Cytochrome P450 3A4-Mediated Drug–Drug Interaction Potential for Cobimetinib Using Physiologically Based Pharmacokinetic Modeling and Simulation

Clinical pharmacokinetics, 2016-11, Vol.55 (11), p.1435-1445

2016

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A physiologically based pharmacokinetic (PBPK) approach to evaluate pharmacokinetics in patients with cancer

Biopharmaceutics & drug disposition, 2013-04, Vol.34 (3), p.141-154

2013

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Absorption, Metabolism, Excretion, and the Contribution of Intestinal Metabolism to the Oral Disposition of [14C]Cobimetinib, a MEK Inhibitor, in Humans

Drug metabolism and disposition, 2016-01, Vol.44 (1), p.28-39

2016

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Absolute Bioavailability and Effect of Formulation Change, Food, or Elevated pH with Rabeprazole on Cobimetinib Absorption in Healthy Subjects

Molecular pharmaceutics, 2013-11, Vol.10 (11), p.4046-4054

2013

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Transporters involved in the elimination of drugs in the kidney: Organic anion transporters and organic cation transporters

Journal of pharmaceutical sciences, 2001-04, Vol.90 (4), p.397-421

2001

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Pharmacokinetics, safety, and tolerability of inhaled remdesivir in healthy participants

Clinical and translational science, 2023-11, Vol.16 (11), p.2276-2288

2023

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A clinical drug–drug interaction study to evaluate the effect of a proton-pump inhibitor, a combined P-glycoprotein/cytochrome 450 enzyme (CYP)3A4 inhibitor, and a CYP2C9 inhibitor on the pharmacokinetics of vismodegib

Cancer chemotherapy and pharmacology, 2016-07, Vol.78 (1), p.41-49

2016

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Single and multiple dose intravenous and oral pharmacokinetics of the hedgehog pathway inhibitor vismodegib in healthy female subjects

British journal of clinical pharmacology, 2012-11, Vol.74 (5), p.788-796

2012

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Single- and Multiple-Dose Pharmacokinetics of Dapoxetine Hydrochloride, a Novel Agent for the Treatment of Premature Ejaculation

Journal of clinical pharmacology, 2006-03, Vol.46 (3), p.301-309

2006

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The Use of Betaine HCl to Enhance Dasatinib Absorption in Healthy Volunteers with Rabeprazole-Induced Hypochlorhydria

The AAPS journal, 2014-11, Vol.16 (6), p.1358-1365

2014

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Impact of Food and the Proton Pump Inhibitor Rabeprazole on the Pharmacokinetics of GDC-0941 in Healthy Volunteers: Bench to Bedside Investigation of pH-Dependent Solubility

Molecular pharmaceutics, 2013-11, Vol.10 (11), p.4074-4081

2013

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Gastric Reacidification with Betaine HCl in Healthy Volunteers with Rabeprazole-Induced Hypochlorhydria

Molecular pharmaceutics, 2013-11, Vol.10 (11), p.4032-4037

2013

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Daily Dosing of Vismodegib to Steady State Does Not Prolong the Qtc Interval in Healthy Volunteers

Journal of cardiovascular pharmacology, 2013-01, Vol.61 (1), p.83-89

2013

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Pharmacokinetics of Dapoxetine, a New Treatment for Premature Ejaculation: Impact of Age and Effects of a High-Fat Meal

Journal of clinical pharmacology, 2006-09, Vol.46 (9), p.1023-1029

2006

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Arginine 454 and Lysine 370 Are Essential for the Anion Specificity of the Organic Anion Transporter, rOAT3

Biochemistry (Easton), 2001-05, Vol.40 (18), p.5511-5520

2001

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Cloning and Functional Expression of a Human Liver Organic Cation Transporter

Molecular pharmacology, 1997-06, Vol.51 (6), p.913-921

1997

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Interactions of n-tetraalkylammonium compounds and biguanides with a human renal organic cation transporter (hOCT2)

Pharmaceutical research, 2002-08, Vol.19 (8), p.1244-1247

2002

Volltextzugriff (PDF)

Na+-dependent purine nucleoside transporter from human kidney: cloning and functional characterization

American journal of physiology. Renal physiology, 1997-12, Vol.273 (6), p.1058-F1065

1997

Volltextzugriff (PDF)

Diversity in Clinical Pharmacology: A Call to Action

Clinical pharmacology and therapeutics, 2023-03, Vol.113 (3), p.483-485

2023

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Specificity of human and rat orthologs of the concentrative nucleoside transporter, SPNT

American journal of physiology. Renal physiology, 2002-08, Vol.283 (2), p.F344-F349

2002

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Kinetic and selectivity differences between rodent, rabbit, and human organic cation transporters (OCT1)

The Journal of pharmacology and experimental therapeutics, 2000-03, Vol.292 (3), p.1146

2000

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Prevalence of Acid-Reducing Agents (ARA) in Cancer Populations and ARA Drug–Drug Interaction Potential for Molecular Targeted Agents in Clinical Development

A Guide to Rational Dosing of Monoclonal Antibodies

Best practices for the use of itraconazole as a replacement for ketoconazole in drug-drug interaction studies

Integrating real‐world data to accelerate and guide drug development: A clinical pharmacology perspective

Evaluation of Cytochrome P450 3A4-Mediated Drug–Drug Interaction Potential for Cobimetinib Using Physiologically Based Pharmacokinetic Modeling and Simulation

A physiologically based pharmacokinetic (PBPK) approach to evaluate pharmacokinetics in patients with cancer

Absorption, Metabolism, Excretion, and the Contribution of Intestinal Metabolism to the Oral Disposition of [14C]Cobimetinib, a MEK Inhibitor, in Humans

Absolute Bioavailability and Effect of Formulation Change, Food, or Elevated pH with Rabeprazole on Cobimetinib Absorption in Healthy Subjects

Transporters involved in the elimination of drugs in the kidney: Organic anion transporters and organic cation transporters

Pharmacokinetics, safety, and tolerability of inhaled remdesivir in healthy participants

A clinical drug–drug interaction study to evaluate the effect of a proton-pump inhibitor, a combined P-glycoprotein/cytochrome 450 enzyme (CYP)3A4 inhibitor, and a CYP2C9 inhibitor on the pharmacokinetics of vismodegib

Single and multiple dose intravenous and oral pharmacokinetics of the hedgehog pathway inhibitor vismodegib in healthy female subjects

Single- and Multiple-Dose Pharmacokinetics of Dapoxetine Hydrochloride, a Novel Agent for the Treatment of Premature Ejaculation

The Use of Betaine HCl to Enhance Dasatinib Absorption in Healthy Volunteers with Rabeprazole-Induced Hypochlorhydria

Impact of Food and the Proton Pump Inhibitor Rabeprazole on the Pharmacokinetics of GDC-0941 in Healthy Volunteers: Bench to Bedside Investigation of pH-Dependent Solubility

Gastric Reacidification with Betaine HCl in Healthy Volunteers with Rabeprazole-Induced Hypochlorhydria

Daily Dosing of Vismodegib to Steady State Does Not Prolong the Qtc Interval in Healthy Volunteers

Pharmacokinetics of Dapoxetine, a New Treatment for Premature Ejaculation: Impact of Age and Effects of a High-Fat Meal

Arginine 454 and Lysine 370 Are Essential for the Anion Specificity of the Organic Anion Transporter, rOAT3

Cloning and Functional Expression of a Human Liver Organic Cation Transporter

Interactions of n-tetraalkylammonium compounds and biguanides with a human renal organic cation transporter (hOCT2)

Na+-dependent purine nucleoside transporter from human kidney: cloning and functional characterization

Diversity in Clinical Pharmacology: A Call to Action

Specificity of human and rat orthologs of the concentrative nucleoside transporter, SPNT

Kinetic and selectivity differences between rodent, rabbit, and human organic cation transporters (OCT1)

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