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Efficacy and Pharmacology of the NLRP3 Inflammasome Inhibitor CP-456,773 (CRID3) in Murine Models of Dermal and Pulmonary Inflammation

The Journal of immunology (1950), 2016-09, Vol.197 (6), p.2421-2433

2016

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A protein kinase C α and β inhibitor blunts hyperphagia to halt renal function decline and reduces adiposity in a rat model of obesity-driven type 2 diabetes

Scientific reports, 2023-10, Vol.13 (1), p.16919-16919, Article 16919

2023

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Interactions between mRNA Export Commitment, 3′-End Quality Control, and Nuclear Degradation

Molecular and Cellular Biology, 2002-12, Vol.22 (23), p.8254-8266

2002

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A synthetic A tail rescues yeast nuclear accumulation of a ribozyme-terminated transcript

RNA (Cambridge), 2004-12, Vol.10 (12), p.1888-1899

2004

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The master regulator of the cellular stress response (HSF1) is critical for orthopoxvirus infection

PLoS pathogens, 2014-02, Vol.10 (2), p.e1003904

2014

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Myxoma and Vaccinia Viruses Bind Differentially to Human Leukocytes

Journal of Virology, 2013-04, Vol.87 (8), p.4445-4460

2013

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T7 RNA polymerase-directed transcripts are processed in yeast and link 3′ end formation to mRNA nuclear export

RNA (Cambridge), 2002-05, Vol.8 (5), p.686-697, Article S1355838202024068

2002

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Stimulation of TLR4 by recombinant HSP70 requires structural integrity of the HSP70 protein itself

Journal of inflammation (London, England), 2012-03, Vol.9 (1), p.11-11, Article 11

2012

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High resolution molecular and histological analysis of renal disease progression in ZSF1 fa/faCP rats, a model of type 2 diabetic nephropathy

PloS one, 2017, Vol.12 (7), p.e0181861-e0181861

2017

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Identification of a Pyridopyrimidinone Inhibitor of Orthopoxviruses from a Diversity-Oriented Synthesis Library

Journal of Virology, 2012-03, Vol.86 (5), p.2632-2640

2012

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41-Week Study of Progressive Diabetic Nephropathy in the ZSF1 fa/fa CP Rat Model

Toxicologic pathology, 2018-12, Vol.46 (8), p.976-977

2018

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41-Week Study of Progressive Diabetic Nephropathy in the ZSF1 fa/faCP Rat Model

Toxicologic pathology, 2018-12, Vol.46 (8), p.976-977

2018

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The Interleukin‐1 Receptor–Associated Kinase 4 Inhibitor PF‐06650833 Blocks Inflammation in Preclinical Models of Rheumatic Disease and in Humans Enrolled in a Randomized Clinical Trial

Arthritis & rheumatology (Hoboken, N.J.), 2021-12, Vol.73 (12), p.2206-2218

2021

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Nuclear Export of Heat Shock and Non-Heat-Shock mRNA Occurs via Similar Pathways

Molecular and Cellular Biology, 2000-06, Vol.20 (11), p.3996-4005

2000

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Discovery of Clinical Candidate 1‑{[(2S,3S,4S)‑3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin‑1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design

Journal of medicinal chemistry, 2017-07, Vol.60 (13), p.5521-5542

2017

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Stricturing Crohn’s Disease Single-Cell RNA Sequencing Reveals Fibroblast Heterogeneity and Intercellular Interactions

Gastroenterology (New York, N.Y. 1943), 2023-11, Vol.165 (5), p.1180-1196

2023

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Innate Immune Responses to TREM-1 Activation: Overlap, Divergence, and Positive and Negative Cross-Talk with Bacterial Lipopolysaccharide

The Journal of immunology (1950), 2008-03, Vol.180 (5), p.3520-3534

2008

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Computational identification and validation of alternative splicing in ZSF1 rat RNA-seq data, a preclinical model for type 2 diabetic nephropathy

Scientific reports, 2018-05, Vol.8 (1), p.7624-8, Article 7624

2018

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Interleukin 1/Toll-like Receptor-induced Autophosphorylation Activates Interleukin 1 Receptor-associated Kinase 4 and Controls Cytokine Induction in a Cell Type-specific Manner

The Journal of biological chemistry, 2014-04, Vol.289 (15), p.10865-10875

2014

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Identification of a broadly fibrogenic macrophage subset induced by type 3 inflammation

Science immunology, 2023-04, Vol.8 (82), p.eadd8945

2023

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Early Formation of mRNP: License for Export or Quality Control?

Molecular Cell, 2003-05, Vol.11 (5), p.1129-1138

2003

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TREM-1 expression is increased in the synovium of rheumatoid arthritis patients and induces the expression of pro-inflammatory cytokines

Rheumatology (Oxford, England), 2009-11, Vol.48 (11), p.1352-1358

2009

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High resolution molecular and histological analysis of renal disease progression in ZSF1 fa/fa.sup.CP rats, a model of type 2 diabetic nephropathy

PloS one, 2017-07, Vol.12 (7), p.e0181861

2017

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Development of Vaccinia reporter viruses for rapid, high content analysis of viral function at all stages of gene expression

Antiviral research, 2011-07, Vol.91 (1), p.72-80

2011

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Efficacy and Pharmacology of the NLRP3 Inflammasome Inhibitor CP-456,773 (CRID3) in Murine Models of Dermal and Pulmonary Inflammation

Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay

A protein kinase C α and β inhibitor blunts hyperphagia to halt renal function decline and reduces adiposity in a rat model of obesity-driven type 2 diabetes

Interactions between mRNA Export Commitment, 3′-End Quality Control, and Nuclear Degradation

A synthetic A tail rescues yeast nuclear accumulation of a ribozyme-terminated transcript

The master regulator of the cellular stress response (HSF1) is critical for orthopoxvirus infection

Myxoma and Vaccinia Viruses Bind Differentially to Human Leukocytes

T7 RNA polymerase-directed transcripts are processed in yeast and link 3′ end formation to mRNA nuclear export

Stimulation of TLR4 by recombinant HSP70 requires structural integrity of the HSP70 protein itself

High resolution molecular and histological analysis of renal disease progression in ZSF1 fa/faCP rats, a model of type 2 diabetic nephropathy

Identification of a Pyridopyrimidinone Inhibitor of Orthopoxviruses from a Diversity-Oriented Synthesis Library

41-Week Study of Progressive Diabetic Nephropathy in the ZSF1 fa/fa CP Rat Model

41-Week Study of Progressive Diabetic Nephropathy in the ZSF1 fa/faCP Rat Model

The Interleukin‐1 Receptor–Associated Kinase 4 Inhibitor PF‐06650833 Blocks Inflammation in Preclinical Models of Rheumatic Disease and in Humans Enrolled in a Randomized Clinical Trial

Nuclear Export of Heat Shock and Non-Heat-Shock mRNA Occurs via Similar Pathways

Discovery of Clinical Candidate 1‑{[(2S,3S,4S)‑3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin‑1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design

Stricturing Crohn’s Disease Single-Cell RNA Sequencing Reveals Fibroblast Heterogeneity and Intercellular Interactions

Innate Immune Responses to TREM-1 Activation: Overlap, Divergence, and Positive and Negative Cross-Talk with Bacterial Lipopolysaccharide

Computational identification and validation of alternative splicing in ZSF1 rat RNA-seq data, a preclinical model for type 2 diabetic nephropathy

Interleukin 1/Toll-like Receptor-induced Autophosphorylation Activates Interleukin 1 Receptor-associated Kinase 4 and Controls Cytokine Induction in a Cell Type-specific Manner

Identification of a broadly fibrogenic macrophage subset induced by type 3 inflammation

Early Formation of mRNP: License for Export or Quality Control?

TREM-1 expression is increased in the synovium of rheumatoid arthritis patients and induces the expression of pro-inflammatory cytokines

High resolution molecular and histological analysis of renal disease progression in ZSF1 fa/fa.sup.CP rats, a model of type 2 diabetic nephropathy

Development of Vaccinia reporter viruses for rapid, high content analysis of viral function at all stages of gene expression

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