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Phosphonate prodrugs: an overview and recent advances

Future medicinal chemistry, 2019-07, Vol.11 (13), p.1625-1643

2019

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The Methylerythritol Phosphate Pathway: Promising Drug Targets in the Fight against Tuberculosis

ACS infectious diseases, 2018-03, Vol.4 (3), p.278-290

2018

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Inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase (Dxr): a review of the synthesis and biological evaluation of recent inhibitors

Current topics in medicinal chemistry, 2012-04, Vol.12 (7), p.706-728

2012

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Potent, specific MEPicides for treatment of zoonotic staphylococci

PLoS pathogens, 2020-06, Vol.16 (6), p.e1007806-e1007806

2020

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Phosphoryl prodrugs: characteristics to improve drug development

Medicinal chemistry research, 2022-02, Vol.31 (2), p.207-216

2022

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Vitamin in the Crosshairs: Targeting Pantothenate and Coenzyme A Biosynthesis for New Antituberculosis Agents

Frontiers in cellular and infection microbiology, 2020-12, Vol.10, p.605662-605662

2020

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PA-824 Kills Nonreplicating Mycobacterium tuberculosis by Intracellular NO Release

Science (American Association for the Advancement of Science), 2008-11, Vol.322 (5906), p.1392-1395

2008

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Lipophilic prodrugs of FR900098 are antimicrobial against Francisella novicida in vivo and in vitro and show GlpT independent efficacy

PloS one, 2012-10, Vol.7 (10), p.e38167

2012

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Identification of a Nitroimidazo-Oxazine-Specific Protein Involved in PA-824 Resistance in Mycobacterium tuberculosis

Proceedings of the National Academy of Sciences - PNAS, 2006-01, Vol.103 (2), p.431-436

2006

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Substrate specificity of the deazaflavin‐dependent nitroreductase from Mycobacterium tuberculosis responsible for the bioreductive activation of bicyclic nitroimidazoles

The FEBS journal, 2012-01, Vol.279 (1), p.113-125

2012

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Prospects for clinical introduction of nitroimidazole antibiotics for the treatment of tuberculosis

Current pharmaceutical design, 2004-10, Vol.10 (26), p.3239-3262

2004

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MEPicides: α,β-Unsaturated Fosmidomycin Analogues as DXR Inhibitors against Malaria

Journal of medicinal chemistry, 2018-10, Vol.61 (19), p.8847-8858

2018

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Structure-guided microbial targeting of antistaphylococcal prodrugs

eLife, 2021-07, Vol.10

2021

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Kinetic characterization and allosteric inhibition of the Yersinia pestis 1-deoxy-D-xylulose 5-phosphate reductoisomerase (MEP synthase)

PloS one, 2014-08, Vol.9 (8), p.e106243-e106243

2014

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MEPicides: potent antimalarial prodrugs targeting isoprenoid biosynthesis

Scientific reports, 2017-08, Vol.7 (1), p.8400-11, Article 8400

2017

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The effect of chain length and unsaturation on Mtb Dxr inhibition and antitubercular killing activity of FR900098 analogs

Bioorganic & medicinal chemistry letters, 2014-01, Vol.24 (2), p.649-653

2014

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Inhibition of DXR in the MEP pathway with lipophilic N -alkoxyaryl FR900098 analogs

RSC medicinal chemistry, 2024-07, Vol.15 (7), p.2422-2439

2024

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Synthetic Fosmidomycin analogues with altered chelating moieties do not inhibit 1-deoxy-d-xylulose 5-phosphate Reductoisomerase or Plasmodium falciparum growth in vitro

Molecules (Basel, Switzerland), 2014-02, Vol.19 (2), p.2571-2587

2014

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Design, synthesis, and evaluation of substituted nicotinamide adenine dinucleotide (NAD+) synthetase inhibitors as potential antitubercular agents

Bioorganic & medicinal chemistry letters, 2017-09, Vol.27 (18), p.4426-4430

2017

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Synthesis and Bioactivity of β‑Substituted Fosmidomycin Analogues Targeting 1‑Deoxy‑d‑xylulose-5-phosphate Reductoisomerase

Journal of medicinal chemistry, 2015-04, Vol.58 (7), p.2988-3001

2015

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Biosynthesis and Recycling of Nicotinamide Cofactors in Mycobacterium tuberculosis: AN ESSENTIAL ROLE FOR NAD IN NONREPLICATING BACILLI

The Journal of biological chemistry, 2008-07, Vol.283 (28), p.19329-19341

2008

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A high-throughput screening campaign to identify inhibitors of DXP reductoisomerase (IspC) and MEP cytidylyltransferase (IspD)

Analytical biochemistry, 2018-02, Vol.542, p.63-75

2018

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Mechanism of Action of N -Acyl and N -Alkoxy Fosmidomycin Analogs: Mono- and Bisubstrate Inhibition of IspC from Plasmodium falciparum , a Causative Agent of Malaria

ACS omega, 2021-10, Vol.6 (42), p.27630-27639

2021

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The Role of MmpL8 in Sulfatide Biogenesis and Virulence of Mycobacterium tuberculosis

The Journal of biological chemistry, 2004-05, Vol.279 (20), p.21257-21265

2004

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Structure−Activity Relationships of Antitubercular Nitroimidazoles. 1. Structural Features Associated with Aerobic and Anaerobic Activities of 4- and 5-Nitroimidazoles

Journal of medicinal chemistry, 2009-03, Vol.52 (5), p.1317-1328

2009

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Phosphonate prodrugs: an overview and recent advances

The Methylerythritol Phosphate Pathway: Promising Drug Targets in the Fight against Tuberculosis

Inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase (Dxr): a review of the synthesis and biological evaluation of recent inhibitors

Potent, specific MEPicides for treatment of zoonotic staphylococci

Phosphoryl prodrugs: characteristics to improve drug development

Vitamin in the Crosshairs: Targeting Pantothenate and Coenzyme A Biosynthesis for New Antituberculosis Agents

PA-824 Kills Nonreplicating Mycobacterium tuberculosis by Intracellular NO Release

Lipophilic prodrugs of FR900098 are antimicrobial against Francisella novicida in vivo and in vitro and show GlpT independent efficacy

Identification of a Nitroimidazo-Oxazine-Specific Protein Involved in PA-824 Resistance in Mycobacterium tuberculosis

Substrate specificity of the deazaflavin‐dependent nitroreductase from Mycobacterium tuberculosis responsible for the bioreductive activation of bicyclic nitroimidazoles

Prospects for clinical introduction of nitroimidazole antibiotics for the treatment of tuberculosis

MEPicides: α,β-Unsaturated Fosmidomycin Analogues as DXR Inhibitors against Malaria

Structure-guided microbial targeting of antistaphylococcal prodrugs

Kinetic characterization and allosteric inhibition of the Yersinia pestis 1-deoxy-D-xylulose 5-phosphate reductoisomerase (MEP synthase)

MEPicides: potent antimalarial prodrugs targeting isoprenoid biosynthesis

The effect of chain length and unsaturation on Mtb Dxr inhibition and antitubercular killing activity of FR900098 analogs

Inhibition of DXR in the MEP pathway with lipophilic N -alkoxyaryl FR900098 analogs

Synthetic Fosmidomycin analogues with altered chelating moieties do not inhibit 1-deoxy-d-xylulose 5-phosphate Reductoisomerase or Plasmodium falciparum growth in vitro

Design, synthesis, and evaluation of substituted nicotinamide adenine dinucleotide (NAD+) synthetase inhibitors as potential antitubercular agents

Synthesis and Bioactivity of β‑Substituted Fosmidomycin Analogues Targeting 1‑Deoxy‑d‑xylulose-5-phosphate Reductoisomerase

Biosynthesis and Recycling of Nicotinamide Cofactors in Mycobacterium tuberculosis: AN ESSENTIAL ROLE FOR NAD IN NONREPLICATING BACILLI

A high-throughput screening campaign to identify inhibitors of DXP reductoisomerase (IspC) and MEP cytidylyltransferase (IspD)

Mechanism of Action of N -Acyl and N -Alkoxy Fosmidomycin Analogs: Mono- and Bisubstrate Inhibition of IspC from Plasmodium falciparum , a Causative Agent of Malaria

The Role of MmpL8 in Sulfatide Biogenesis and Virulence of Mycobacterium tuberculosis

Structure−Activity Relationships of Antitubercular Nitroimidazoles. 1. Structural Features Associated with Aerobic and Anaerobic Activities of 4- and 5-Nitroimidazoles

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