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The effects of bariatric surgery on islet function, insulin secretion, & glucose control

Endocrine reviews, 2019-10, Vol.40 (5), p.1394-1423

2019

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Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist

JCI insight, 2020-09, Vol.5 (17)

2020

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Ildr1 gene deletion protects against diet-induced obesity and hyperglycemia

PloS one, 2022-06, Vol.17 (6), p.e0270329-e0270329

2022

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Next generation GLP-1/GIP/glucagon triple agonists normalize body weight in obese mice

Molecular metabolism (Germany), 2022-09, Vol.63, p.101533-101533, Article 101533

2022

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Leptin stimulates hepatic growth hormone receptor and insulin-like growth factor gene expression in a teleost fish, the hybrid striped bass

General and comparative endocrinology, 2016-04, Vol.229, p.84-91

2016

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The GLP-1R as a model for understanding and exploiting biased agonism in next-generation medicines

Journal of endocrinology, 2024-05, Vol.261 (2)

2024

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Discovery of a potent GIPR peptide antagonist that is effective in rodent and human systems

Molecular metabolism (Germany), 2022-12, Vol.66, p.101638-101638, Article 101638

2022

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GLP-1/GIP/glucagon receptor triagonism gets its try in humans

Cell metabolism, 2022-01, Vol.34 (1), p.3-4

2022

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1838-P: Vertical Sleeve Gastrectomy Improves Glycemia Independent of Caloric Restriction through a Coordinated Regulation of Incretin Secretion, Insulin Sensitivity, and Islet Function

Diabetes (New York, N.Y.), 2019-06, Vol.68 (Supplement_1)

DOUROS, JONATHAN D.

2019

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Leptin Stimulates Cellular Glycolysis Through a STAT3 Dependent Mechanism in Tilapia

Frontiers in endocrinology (Lausanne), 2018-08, Vol.9, p.465-465

2018

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Loss of GIPR in LEPR cells impairs glucose control by GIP and GIP:GLP-1 co-agonism without affecting body weight and food intake in mice

Molecular metabolism (Germany), 2024-05, Vol.83, p.101915-101915, Article 101915

2024

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Prolactin is a major inhibitor of hepatic Leptin A synthesis and secretion: Studies utilizing a homologous Leptin A ELISA in the tilapia

General and comparative endocrinology, 2014-10, Vol.207, p.86-93

2014

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Temporal plasticity of insulin and incretin secretion and insulin sensitivity following sleeve gastrectomy contribute to sustained improvements in glucose control

Molecular metabolism (Germany), 2019-10, Vol.28, p.144-150

2019

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SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion

Cell metabolism, 2017-04, Vol.25 (4), p.838-855.e15

2017

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2095-P: ß-Cell Glucose-Dependent Insulinotropic Polypeptide Receptors Are Necessary for Improved Islet Function following Sleeve Gastrectomy

Diabetes (New York, N.Y.), 2020-06, Vol.69 (Supplement_1)

2020

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325-OR: ß-Arrestin 1 Regulates Glucagon-Like Peptide-1 Receptor Mediated Insulin Secretion in a Ligand-Dependent Manner

Diabetes (New York, N.Y.), 2020-06, Vol.69 (Supplement_1)

2020

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Reg3 Proteins as Gut Hormones? Don’t Be Hasty

Endocrinology (Philadelphia), 2019-07, Vol.160 (7), p.1677-1678

2019

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Optimization of Truncated Glucagon Peptides to Achieve Selective, High Potency, Full Antagonists

Journal of medicinal chemistry, 2021-04, Vol.64 (8), p.4697-4708

2021

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The Limited Role of Glucagon for Ketogenesis During Fasting or in Response to SGLT2 Inhibition

Diabetes (New York, N.Y.), 2020-05, Vol.69 (5), p.882-892

2020

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Epinephrine and glucose regulation of leptin synthesis and secretion in a teleost fish, the tilapia (Oreochromis mossambicus)

General and comparative endocrinology, 2021-02, Vol.302, p.113669-113669, Article 113669

2021

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Enhanced Glucose Control Following Vertical Sleeve Gastrectomy Does Not Require a β-Cell Glucagon-Like Peptide 1 Receptor

Diabetes (New York, N.Y.), 2018-08, Vol.67 (8), p.1504-1511

2018

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The incretin co-agonist tirzepatide requires GIPR for hormone secretion from human islets

Nature metabolism, 2023-06, Vol.5 (6), p.945

2023

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Control of leptin by metabolic state and its regulatory interactions with pituitary growth hormone and hepatic growth hormone receptors and insulin like growth factors in the tilapia ( Oreochromis mossambicus )

General and comparative endocrinology, 2017-01, Vol.240, p.227-237

2017

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Sleeve gastrectomy rapidly enhances islet function independently of body weight

JCI insight, 2019-03, Vol.4 (6)

2019

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The effects of bariatric surgery on islet function, insulin secretion, & glucose control

Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist

Ildr1 gene deletion protects against diet-induced obesity and hyperglycemia

Next generation GLP-1/GIP/glucagon triple agonists normalize body weight in obese mice

Leptin stimulates hepatic growth hormone receptor and insulin-like growth factor gene expression in a teleost fish, the hybrid striped bass

The GLP-1R as a model for understanding and exploiting biased agonism in next-generation medicines

Discovery of a potent GIPR peptide antagonist that is effective in rodent and human systems

GLP-1/GIP/glucagon receptor triagonism gets its try in humans

1838-P: Vertical Sleeve Gastrectomy Improves Glycemia Independent of Caloric Restriction through a Coordinated Regulation of Incretin Secretion, Insulin Sensitivity, and Islet Function

Leptin Stimulates Cellular Glycolysis Through a STAT3 Dependent Mechanism in Tilapia

Loss of GIPR in LEPR cells impairs glucose control by GIP and GIP:GLP-1 co-agonism without affecting body weight and food intake in mice

Prolactin is a major inhibitor of hepatic Leptin A synthesis and secretion: Studies utilizing a homologous Leptin A ELISA in the tilapia

Temporal plasticity of insulin and incretin secretion and insulin sensitivity following sleeve gastrectomy contribute to sustained improvements in glucose control

SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion

2095-P: ß-Cell Glucose-Dependent Insulinotropic Polypeptide Receptors Are Necessary for Improved Islet Function following Sleeve Gastrectomy

325-OR: ß-Arrestin 1 Regulates Glucagon-Like Peptide-1 Receptor Mediated Insulin Secretion in a Ligand-Dependent Manner

Reg3 Proteins as Gut Hormones? Don’t Be Hasty

Optimization of Truncated Glucagon Peptides to Achieve Selective, High Potency, Full Antagonists

The Limited Role of Glucagon for Ketogenesis During Fasting or in Response to SGLT2 Inhibition

Epinephrine and glucose regulation of leptin synthesis and secretion in a teleost fish, the tilapia (Oreochromis mossambicus)

Enhanced Glucose Control Following Vertical Sleeve Gastrectomy Does Not Require a β-Cell Glucagon-Like Peptide 1 Receptor

The incretin co-agonist tirzepatide requires GIPR for hormone secretion from human islets

Control of leptin by metabolic state and its regulatory interactions with pituitary growth hormone and hepatic growth hormone receptors and insulin like growth factors in the tilapia ( Oreochromis mossambicus )

Sleeve gastrectomy rapidly enhances islet function independently of body weight

Glucose-dependent insulinotropic polypeptide regulates body weight and food intake via GABAergic neurons in mice

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