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The Structure of the GM-CSF Receptor Complex Reveals a Distinct Mode of Cytokine Receptor Activation

Cell, 2008-08, Vol.134 (3), p.496-507

2008

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Conformational Changes in the GM-CSF Receptor Suggest a Molecular Mechanism for Affinity Conversion and Receptor Signaling

Structure (London), 2016-08, Vol.24 (8), p.1271-1281

2016

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A dual role for the N-terminal domain of the IL-3 receptor in cell signalling

Nature communications, 2018-01, Vol.9 (1), p.386-15, Article 386

2018

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Accumulation of JAK activation loop phosphorylation is linked to type I JAK inhibitor withdrawal syndrome in myelofibrosis

Science advances, 2018-11, Vol.4 (11), p.eaat3834

2018

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Dual Mechanism of Interleukin-3 Receptor Blockade by an Anti-Cancer Antibody

Cell reports (Cambridge), 2014-07, Vol.8 (2), p.410-419

2014

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Differential functional activation of chemokine receptor CXCR4 is mediated by G proteins in breast cancer cells

Cancer research (Chicago, Ill.), 2006-04, Vol.66 (8), p.4117-4124

2006

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High yield production of a soluble human interleukin-3 variant from E. coli with wild-type bioactivity and improved radiolabeling properties

PloS one, 2013-08, Vol.8 (8), p.e74376-e74376

2013

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High CD123 levels enhance proliferation in response to IL-3, but reduce chemotaxis by downregulating CXCR4 expression

Blood advances, 2017-06, Vol.1 (15), p.1067-1079

2017

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A Calreticulin Neoepitope-Directed Monoclonal Antibody Can Overcome JAK Inhibitor Resistance and Block TPO-Independent Megakaryocyte Differentation

Blood, 2021-11, Vol.138 (Supplement 1), p.3597-3597

2021

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Targeting human CALR‐mutated MPN progenitors with a neoepitope‐directed monoclonal antibody

EMBO reports, 2022-04, Vol.23 (4), p.e52904-n/a

2022

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Distinct Assemblies of Heterodimeric Cytokine Receptors Govern Stemness Programs in Leukemia

Cancer discovery, 2023-08, Vol.13 (8), p.1922-1947

2023

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Accumulation of JAK Activation-Loop Phosphorylation Promotes Type I JAK Inhibitor Withdrawal Syndrome in Myelofibrosis

Blood, 2018-11, Vol.132 (Supplement 1), p.1787-1787

2018

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The GM-CSF receptor – mechanisms for affinity conversion and signalling

Acta crystallographica. Section A, Foundations and advances, 2017-12, Vol.73 (a2), p.C1279-C1279

2017

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17: Structural and functional analysis of the GM-CSF:GM-CSF receptor alpha chain binary complex provide new insights into signalling of the GM-CSF ternary complex

Cytokine (Philadelphia, Pa.), 2014-11, Vol.70 (1), p.32-32

2014

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17

Cytokine (Philadelphia, Pa.), 2014-11, Vol.70 (1), p.32

2014

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Growth factor pleiotropy is controlled by a receptor Tyr/Ser motif that acts as a binary switch

The EMBO journal, 2006-02, Vol.25 (3), p.479-489

2006

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78

Cytokine (Philadelphia, Pa.), 2014-11, Vol.70 (1), p.46

2014

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78: Insights into the function of an anti-leukaemia antibody: structural studies of CSL362 bound to soluble CD123

Cytokine (Philadelphia, Pa.), 2014-11, Vol.70 (1), p.46-46

2014

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Site-Specific Serine Phosphorylation of the IL-3 Receptor Is Required for Hemopoietic Cell Survival

Molecular cell, 2000-07, Vol.6 (1), p.99-108

2000

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High Yield Production of a Soluble Human Interleukin-3 Variant from E. coli with Wild-Type Bioactivity and Improved Radiolabeling Properties: e74376

PloS one, 2013-08, Vol.8 (8)

2013

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Differential Binding of IL-3 and GM-CSF to Human Monocytes

Growth factors (Chur, Switzerland), 1992, Vol.6 (1), p.15-29

1992

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Specific Human Granulocyte-Macrophage Colony-Stimulating Factor Antagonists

Proceedings of the National Academy of Sciences - PNAS, 1994-06, Vol.91 (13), p.5838-5842

1994

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Identification of Residues in the First and Fourth Helices of Human Granulocyte-Macrophage Colony-Stimulating Factor Involved in Biologic Activity and in Binding to the α- and β-Chains of Its Receptor

Blood, 1994-06, Vol.83 (12), p.3500-3508

1994

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The Receptor for Interleukin 3 is Selectively Induced in Human Endothelial Cells by Tumor Necrosis Factor α and Potentiates Interleukin 8 Secretion and Neutrophil Transmigration

Proceedings of the National Academy of Sciences - PNAS, 1993-12, Vol.90 (23), p.11137-11141

1993

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The Structure of the GM-CSF Receptor Complex Reveals a Distinct Mode of Cytokine Receptor Activation

Conformational Changes in the GM-CSF Receptor Suggest a Molecular Mechanism for Affinity Conversion and Receptor Signaling

A dual role for the N-terminal domain of the IL-3 receptor in cell signalling

Accumulation of JAK activation loop phosphorylation is linked to type I JAK inhibitor withdrawal syndrome in myelofibrosis

Dual Mechanism of Interleukin-3 Receptor Blockade by an Anti-Cancer Antibody

Differential functional activation of chemokine receptor CXCR4 is mediated by G proteins in breast cancer cells

High yield production of a soluble human interleukin-3 variant from E. coli with wild-type bioactivity and improved radiolabeling properties

High CD123 levels enhance proliferation in response to IL-3, but reduce chemotaxis by downregulating CXCR4 expression

A Calreticulin Neoepitope-Directed Monoclonal Antibody Can Overcome JAK Inhibitor Resistance and Block TPO-Independent Megakaryocyte Differentation

Targeting human CALR‐mutated MPN progenitors with a neoepitope‐directed monoclonal antibody

Distinct Assemblies of Heterodimeric Cytokine Receptors Govern Stemness Programs in Leukemia

Accumulation of JAK Activation-Loop Phosphorylation Promotes Type I JAK Inhibitor Withdrawal Syndrome in Myelofibrosis

The GM-CSF receptor – mechanisms for affinity conversion and signalling

CSL311, a novel, potent, therapeutic monoclonal antibody for the treatment of diseases mediated by the common β chain of the IL-3, GM-CSF and IL-5 receptors

17: Structural and functional analysis of the GM-CSF:GM-CSF receptor alpha chain binary complex provide new insights into signalling of the GM-CSF ternary complex

17

Growth factor pleiotropy is controlled by a receptor Tyr/Ser motif that acts as a binary switch

78

78: Insights into the function of an anti-leukaemia antibody: structural studies of CSL362 bound to soluble CD123

Site-Specific Serine Phosphorylation of the IL-3 Receptor Is Required for Hemopoietic Cell Survival

High Yield Production of a Soluble Human Interleukin-3 Variant from E. coli with Wild-Type Bioactivity and Improved Radiolabeling Properties: e74376

Differential Binding of IL-3 and GM-CSF to Human Monocytes

Specific Human Granulocyte-Macrophage Colony-Stimulating Factor Antagonists

Identification of Residues in the First and Fourth Helices of Human Granulocyte-Macrophage Colony-Stimulating Factor Involved in Biologic Activity and in Binding to the α- and β-Chains of Its Receptor

The Receptor for Interleukin 3 is Selectively Induced in Human Endothelial Cells by Tumor Necrosis Factor α and Potentiates Interleukin 8 Secretion and Neutrophil Transmigration

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