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Structure of human neutrophil elastase in complex with a peptide chloromethyl ketone inhibitor at 1.84-A resolution

Proceedings of the National Academy of Sciences - PNAS, 1989-01, Vol.86 (1), p.7-11

1989

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Orally active .beta.-lactam inhibitors of human leukocyte elastase-1. Activity of 3,3-diethyl-2-azetidinones

Journal of medicinal chemistry, 1992-10, Vol.35 (21), p.3745-3754

1992

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Phosphorylated Morpholine Acetal Human Neurokinin-1 Receptor Antagonists as Water-Soluble Prodrugs

Journal of medicinal chemistry, 2000-03, Vol.43 (6), p.1234-1241

2000

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Chemical, Biochemical, Pharmacokinetic, and Biological Properties of L-680, 833: A Potent, Orally Active Monocyclic β-Lactam Inhibitor of Human Polymorphonuclear Leukocyte Elastase

Proceedings of the National Academy of Sciences - PNAS, 1993-09, Vol.90 (18), p.8727-8731

1993

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Specificity, stability, and potency of monocyclic β-lactam inhibitors of human leucocyte elastase

Biochemistry (Easton), 1992-09, Vol.31 (35), p.8160-8170

1992

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Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 1: Discovery and initial structure-activity relationships for 1-amino-2-phenyl-4-(piperidin-1-yl)butanes

Bioorganic & medicinal chemistry letters, 2001-01, Vol.11 (2), p.259-264

2001

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Specificity, stability, and potency of monocyclic .beta.-lactam inhibitors of human leukocyte elastase

Biochemistry (Easton), 1992-09, Vol.31 (35), p.8160-8170

1992

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Mechanism of inhibition of human leucocyte elastase by monocyclic β-lactams

Biochemistry (Easton), 1993-08, Vol.32 (34), p.8970-8980

1993

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Crystallization of human neutrophil elastase

The Journal of biological chemistry, 1987-12, Vol.262 (35), p.17178-17181

1987

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Mechanism of inhibition of human leukocyte elastase by monocyclic .beta.-lactams

Biochemistry (Easton), 1993-08, Vol.32 (34), p.8970-8980

1993

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Inhibition of human leukocyte elastase. 1. Inhibition by C-7-substituted cephalosporin tert-butyl esters

Journal of medicinal chemistry, 1990-09, Vol.33 (9), p.2513-2521

1990

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A new fluorogenic substrate for plasmin

Biochemical journal, 1979-12, Vol.183 (3), p.555-559

1979

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Novel nucleophilic substitution of alkyl bromo-2(1H)-pyridones

Journal of heterocyclic chemistry, 1985-03, Vol.22 (2), p.265-272

1985

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Inhibition of human leukocyte elastase. 4. Selection of a substituted cephalosporin (L-658,758) as a topical aerosol

Journal of medicinal chemistry, 1992-10, Vol.35 (21), p.3731-3744

1992

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Synthesis and antiinflammatory/analgesic activities of 11H-dibenzo[b,e]dioxepinacetic acids

Journal of medicinal chemistry, 1986-08, Vol.29 (8), p.1436-1441

1986

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Synthesis and immunoadjuvant activities of 2-acetamido-5-O-acetyl-6-O-acyl-2-deoxy-3-O-[(R)-2-propionyl-L-alanyl-D-isoglutamine]-D-glucofuranoses as potential prodrug forms of 6-O-acyl derivatives of N-acetylmuramyl dipeptide

Journal of medicinal chemistry, 1982-09, Vol.25 (9), p.1028-1033

1982

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Orally active .beta.-lactam inhibitors of human leukocyte elastase. 2. Effect of C-4 substitution

Journal of medicinal chemistry, 1993-03, Vol.36 (6), p.771-777

1993

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Cephalosporin antibiotics can be modified to inhibit human leukocyte elastase

Nature (London), 1986-07, Vol.322 (6075), p.192-194

1986

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1,4-Diacylpiperazine-2-(S)-[(N-aminoalkyl)carboxamides] as novel, potent substance P receptor antagonists

Bioorganic & medicinal chemistry letters, 1993-12, Vol.3 (12), p.2707-2712

1993

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Proteoglycan-degrading activity of human stromelysin-1 and leukocyte elastase in rabbit joints. Quantitation of proteoglycan and a stromelysin-induced HABR fragment of aggrecan in synovial fluid and cartilage

Connective tissue research, 1996, Vol.33 (4), p.291-299

1996

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Expression and characterization of the chemokine receptor CCR2B from rhesus monkey

Biochemical pharmacology, 2003-07, Vol.66 (2), p.321-330

2003

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Synthesis and acylation of 2-nitro-11H-dibenzo[b,e][1,4]dioxepin

Journal of heterocyclic chemistry, 1986-05, Vol.23 (3), p.673-677

1986

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Mechanism of inhibition of human leucocyte elastase by beta-lactams. 2. Stability, reactivation kinetics, and products of beta-lactam-derived E-I complexes

Biochemistry (Easton), 1995-11, Vol.34 (44), p.14331-14343

1995

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Synthesis of 24-dehydrocholecalciferol

Steroids, 1980-03, Vol.35 (3), p.329-334

1980

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Steroids 23. Synthesis fo some ring A-fused heterocyclic steroids

Journal of pharmaceutical sciences, 1965-08, Vol.54 (8), p.1219-1221

1965

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Structure of human neutrophil elastase in complex with a peptide chloromethyl ketone inhibitor at 1.84-A resolution

Orally active .beta.-lactam inhibitors of human leukocyte elastase-1. Activity of 3,3-diethyl-2-azetidinones

Phosphorylated Morpholine Acetal Human Neurokinin-1 Receptor Antagonists as Water-Soluble Prodrugs

Chemical, Biochemical, Pharmacokinetic, and Biological Properties of L-680, 833: A Potent, Orally Active Monocyclic β-Lactam Inhibitor of Human Polymorphonuclear Leukocyte Elastase

Specificity, stability, and potency of monocyclic β-lactam inhibitors of human leucocyte elastase

Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 1: Discovery and initial structure-activity relationships for 1-amino-2-phenyl-4-(piperidin-1-yl)butanes

Specificity, stability, and potency of monocyclic .beta.-lactam inhibitors of human leukocyte elastase

Mechanism of inhibition of human leucocyte elastase by monocyclic β-lactams

Crystallization of human neutrophil elastase

Mechanism of inhibition of human leukocyte elastase by monocyclic .beta.-lactams

Inhibition of human leukocyte elastase. 1. Inhibition by C-7-substituted cephalosporin tert-butyl esters

A new fluorogenic substrate for plasmin

Novel nucleophilic substitution of alkyl bromo-2(1H)-pyridones

Inhibition of human leukocyte elastase. 4. Selection of a substituted cephalosporin (L-658,758) as a topical aerosol

Synthesis and antiinflammatory/analgesic activities of 11H-dibenzo[b,e]dioxepinacetic acids

Synthesis and immunoadjuvant activities of 2-acetamido-5-O-acetyl-6-O-acyl-2-deoxy-3-O-[(R)-2-propionyl-L-alanyl-D-isoglutamine]-D-glucofuranoses as potential prodrug forms of 6-O-acyl derivatives of N-acetylmuramyl dipeptide

Orally active .beta.-lactam inhibitors of human leukocyte elastase. 2. Effect of C-4 substitution

Cephalosporin antibiotics can be modified to inhibit human leukocyte elastase

1,4-Diacylpiperazine-2-(S)-[(N-aminoalkyl)carboxamides] as novel, potent substance P receptor antagonists

Proteoglycan-degrading activity of human stromelysin-1 and leukocyte elastase in rabbit joints. Quantitation of proteoglycan and a stromelysin-induced HABR fragment of aggrecan in synovial fluid and cartilage

Expression and characterization of the chemokine receptor CCR2B from rhesus monkey

Synthesis and acylation of 2-nitro-11H-dibenzo[b,e][1,4]dioxepin

Mechanism of inhibition of human leucocyte elastase by beta-lactams. 2. Stability, reactivation kinetics, and products of beta-lactam-derived E-I complexes

Synthesis of 24-dehydrocholecalciferol

Steroids 23. Synthesis fo some ring A-fused heterocyclic steroids

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