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Miltefosine: a review of its pharmacology and therapeutic efficacy in the treatment of leishmaniasis

Journal of antimicrobial chemotherapy, 2012-11, Vol.67 (11), p.2576-2597

2012

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Increasing Failure of Miltefosine in the Treatment of Kala-azar in Nepal and the Potential Role of Parasite Drug Resistance, Reinfection, or Noncompliance

Clinical infectious diseases, 2013-06, Vol.56 (11), p.1530-1538

2013

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Failure of miltefosine treatment for visceral leishmaniasis in children and men in South-East Asia

PloS one, 2014-06, Vol.9 (6), p.e100220

2014

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Efficacy and Safety of AmBisome in Combination with Sodium Stibogluconate or Miltefosine and Miltefosine Monotherapy for African Visceral Leishmaniasis: Phase II Randomized Trial

PLoS neglected tropical diseases, 2016-09, Vol.10 (9), p.e0004880-e0004880

2016

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Optimal Dosing of Miltefosine in Children and Adults with Visceral Leishmaniasis

Antimicrobial Agents and Chemotherapy, 2012-07, Vol.56 (7), p.3864-3872

2012

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Safety and efficacy of paromomycin/miltefosine/liposomal amphotericin B combinations for the treatment of post-kala-azar dermal leishmaniasis in Sudan: A phase II, open label, randomized, parallel arm study

PLoS neglected tropical diseases, 2023-11, Vol.17 (11), p.e0011780-e0011780

2023

Volltextzugriff (PDF)

Leishmania blood parasite dynamics during and after treatment of visceral leishmaniasis in Eastern Africa: A pharmacokinetic-pharmacodynamic model

PLoS neglected tropical diseases, 2024-04, Vol.18 (4), p.e0012078-e0012078

2024

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Systematic review of biomarkers to monitor therapeutic response in leishmaniasis

Antimicrobial agents and chemotherapy, 2015-01, Vol.59 (1), p.1-14

2015

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Systematic Review of Host-Mediated Activity of Miltefosine in Leishmaniasis through Immunomodulation

Antimicrobial agents and chemotherapy, 2019-07, Vol.63 (7)

2019

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Pharmacokinetics of Miltefosine in Old World Cutaneous Leishmaniasis Patients

Antimicrobial Agents and Chemotherapy, 2008-08, Vol.52 (8), p.2855-2860

2008

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A physiologically based pharmacokinetic model for [68Ga]Ga-(HA-)DOTATATE to predict whole-body distribution and tumor sink effects in GEP-NET patients

EJNMMI research, 2023-02, Vol.13 (1), p.8-8, Article 8

2023

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Population Pharmacokinetics of Fludarabine in Children and Adults during Conditioning Prior to Allogeneic Hematopoietic Cell Transplantation

Clinical pharmacokinetics, 2019-05, Vol.58 (5), p.627-637

2019

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Failure of Miltefosine in Visceral Leishmaniasis Is Associated With Low Drug Exposure

The Journal of infectious diseases, 2014-07, Vol.210 (1), p.146-153

2014

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Lopinavir/ritonavir significantly influences pharmacokinetic exposure of artemether/lumefantrine in HIV-infected Ugandan adults

Journal of antimicrobial chemotherapy, 2012-05, Vol.67 (5), p.1217-1223

2012

Volltextzugriff (PDF)

Predicting [177Lu]Lu-HA-DOTATATE kidney and tumor accumulation based on [68Ga]Ga-HA-DOTATATE diagnostic imaging using semi-physiological population pharmacokinetic modeling

EJNMMI physics, 2023-08, Vol.10 (1), p.48-48, Article 48

2023

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Characterization and identification of suspected counterfeit miltefosine capsules

Analyst (London), 2012-03, Vol.137 (5), p.1265-1274

2012

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Severe encephalopathy and polyneuropathy induced by dichloroacetate

Journal of neurology, 2010-12, Vol.257 (12), p.2099-2100

2010

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Pharmacokinetics of Miltefosine in Children and Adults with Cutaneous Leishmaniasis

Antimicrobial agents and chemotherapy, 2017-03, Vol.61 (3)

2017

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Pharmacokinetic Targets for Therapeutic Drug Monitoring of Small Molecule Kinase Inhibitors in Pediatric Oncology

Clinical pharmacology and therapeutics, 2020-09, Vol.108 (3), p.494-505

2020

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Translational pharmacokinetic modelling and simulation for the assessment of duration of contraceptive use after treatment with miltefosine

Journal of antimicrobial chemotherapy, 2012-08, Vol.67 (8), p.1996-2004

2012

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Editorial: Emerging talents in Frontiers in Pharmacology: Drug metabolism and transport 2022

Frontiers in pharmacology, 2022-12, Vol.13, p.1083163

2022

Volltextzugriff (PDF)

Population Pharmacokinetics of Artemether, Dihydroartemisinin, and Lumefantrine in Rwandese Pregnant Women Treated for Uncomplicated Plasmodium falciparum Malaria

Antimicrobial agents and chemotherapy, 2018-10, Vol.62 (10)

2018

Volltextzugriff (PDF)

Development of a population pharmacokinetic/pharmacodynamic model for various oral paclitaxel formulations co-administered with ritonavir and thrombospondin-1 based on data from early phase clinical studies

Cancer chemotherapy and pharmacology, 2022-07, Vol.90 (1), p.71-82

2022

Volltextzugriff (PDF)

Safety and efficacy of single dose versus multiple doses of AmBisome for treatment of visceral leishmaniasis in eastern Africa: a randomised trial

PLoS neglected tropical diseases, 2014-01, Vol.8 (1), p.e2613

2014

Volltextzugriff (PDF)

Dynamics of parasite clearance in cutaneous leishmaniasis patients treated with miltefosine

PLoS neglected tropical diseases, 2011-12, Vol.5 (12), p.e1436-e1436

2011

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Miltefosine: a review of its pharmacology and therapeutic efficacy in the treatment of leishmaniasis

Increasing Failure of Miltefosine in the Treatment of Kala-azar in Nepal and the Potential Role of Parasite Drug Resistance, Reinfection, or Noncompliance

Failure of miltefosine treatment for visceral leishmaniasis in children and men in South-East Asia

Efficacy and Safety of AmBisome in Combination with Sodium Stibogluconate or Miltefosine and Miltefosine Monotherapy for African Visceral Leishmaniasis: Phase II Randomized Trial

Optimal Dosing of Miltefosine in Children and Adults with Visceral Leishmaniasis

Safety and efficacy of paromomycin/miltefosine/liposomal amphotericin B combinations for the treatment of post-kala-azar dermal leishmaniasis in Sudan: A phase II, open label, randomized, parallel arm study

Leishmania blood parasite dynamics during and after treatment of visceral leishmaniasis in Eastern Africa: A pharmacokinetic-pharmacodynamic model

Systematic review of biomarkers to monitor therapeutic response in leishmaniasis

Systematic Review of Host-Mediated Activity of Miltefosine in Leishmaniasis through Immunomodulation

Pharmacokinetics of Miltefosine in Old World Cutaneous Leishmaniasis Patients

A physiologically based pharmacokinetic model for [68Ga]Ga-(HA-)DOTATATE to predict whole-body distribution and tumor sink effects in GEP-NET patients

Population Pharmacokinetics of Fludarabine in Children and Adults during Conditioning Prior to Allogeneic Hematopoietic Cell Transplantation

Failure of Miltefosine in Visceral Leishmaniasis Is Associated With Low Drug Exposure

Lopinavir/ritonavir significantly influences pharmacokinetic exposure of artemether/lumefantrine in HIV-infected Ugandan adults

Predicting [177Lu]Lu-HA-DOTATATE kidney and tumor accumulation based on [68Ga]Ga-HA-DOTATATE diagnostic imaging using semi-physiological population pharmacokinetic modeling

Characterization and identification of suspected counterfeit miltefosine capsules

Severe encephalopathy and polyneuropathy induced by dichloroacetate

Pharmacokinetics of Miltefosine in Children and Adults with Cutaneous Leishmaniasis

Pharmacokinetic Targets for Therapeutic Drug Monitoring of Small Molecule Kinase Inhibitors in Pediatric Oncology

Translational pharmacokinetic modelling and simulation for the assessment of duration of contraceptive use after treatment with miltefosine

Editorial: Emerging talents in Frontiers in Pharmacology: Drug metabolism and transport 2022

Population Pharmacokinetics of Artemether, Dihydroartemisinin, and Lumefantrine in Rwandese Pregnant Women Treated for Uncomplicated Plasmodium falciparum Malaria

Development of a population pharmacokinetic/pharmacodynamic model for various oral paclitaxel formulations co-administered with ritonavir and thrombospondin-1 based on data from early phase clinical studies

Safety and efficacy of single dose versus multiple doses of AmBisome for treatment of visceral leishmaniasis in eastern Africa: a randomised trial

Dynamics of parasite clearance in cutaneous leishmaniasis patients treated with miltefosine

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