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Bis-Cyclic Guanidine Heterocyclic Peptidomimetics as Opioid Ligands with Mixed μ-, κ- and δ-Opioid Receptor Interactions: A Potential Approach to Novel Analgesics

International journal of molecular sciences, 2022-08, Vol.23 (17), p.9623

2022

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Imaging Dynamic Redox Changes in Mammalian Cells with Green Fluorescent Protein Indicators

The Journal of biological chemistry, 2004-05, Vol.279 (21), p.22284-22293

2004

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Bridging immunogenetics and immunoproteomics: Model positional scanning library analysis for Major Histocompatibility Complex class II DQ in Tursiops truncatus

PloS one, 2018-08, Vol.13 (8), p.e0201299-e0201299

2018

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Mixture-Based Synthetic Combinatorial Libraries

Journal of medicinal chemistry, 1999-09, Vol.42 (19), p.3743-3778

1999

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Antinociceptive activity of thiazole-containing cyclized DAMGO and Leu-(Met) enkephalin analogs

Organic & biomolecular chemistry, 2019-06, Vol.17 (21), p.535-5315

2019

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Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery

Nature (London), 1991-11, Vol.354 (6348), p.84-86

1991

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Parallel Synthesis of Hexahydrodiimidazodiazepines Heterocyclic Peptidomimetics and Their in Vitro and in Vivo Activities at μ (MOR), δ (DOR), and κ (KOR) Opioid Receptors

Journal of medicinal chemistry, 2015-06, Vol.58 (12), p.4905-4917

2015

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Synthesis and analgesic activity of alkylated, reduced and constrained oligoheterocyclic peptidomimetic analogs of Leu-enkephalin

Bioorganic & medicinal chemistry letters, 2014-09, Vol.24 (18), p.4482-4485

2014

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Identification of Two Novel, Potent, Low-Liability Antinociceptive Compounds from the Direct In Vivo Screening of a Large Mixture-Based Combinatorial Library

The AAPS journal, 2010-09, Vol.12 (3), p.318-329

2010

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A one-pot multicomponent approach to a new series of morphine derivatives and their biological evaluation

Organic & biomolecular chemistry, 2017-09, Vol.15 (37), p.7796-7801

2017

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Ligand/kappa-opioid receptor interactions: Insights from the X-ray crystal structure

European journal of medicinal chemistry, 2013-08, Vol.66, p.114-121

2013

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Direct Phenotypic Screening in Mice: Identification of Individual, Novel Antinociceptive Compounds from a Library of 734 821 Pyrrolidine Bis-piperazines

ACS combinatorial science, 2016-01, Vol.18 (1), p.51-64

2016

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Toxicity of 6-hydroxydopamine: live cell imaging of cytoplasmic redox flux

Cell biology and toxicology, 2012-04, Vol.28 (2), p.89-101

2012

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Fluorescent Mu Selective Opioid Ligands from a Mixture Based Cyclic Peptide Library

ACS combinatorial science, 2012-12, Vol.14 (12), p.673-679

2012

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A Novel Method for the Determination of Isokinetic Ratios and Its Application in the Synthesis of Two New Positional Scanning Libraries

ACS combinatorial science, 2012-09, Vol.14 (9), p.503-512

2012

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Use and Implications of the Harmonic Mean Model on Mixtures for Basic Research and Drug Discovery

ACS combinatorial science, 2011-05, Vol.13 (3), p.337-344

2011

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Conformation-opioid activity relationships of bicyclic guanidines from 3D similarity analysis

Bioorganic & medicinal chemistry, 2008-06, Vol.16 (11), p.5932-5938

2008

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The pharmacological properties of a novel MCH1 receptor antagonist isolated from combinatorial libraries

European journal of pharmacology, 2009-01, Vol.602 (2-3), p.194-202

2009

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Identification, structure–activity relationships and molecular modeling of potent triamine and piperazine opioid ligands

Bioorganic & medicinal chemistry, 2009-08, Vol.17 (15), p.5583-5597

2009

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Binding and in vitro activities of peptides with high affinity for the nociceptin/orphanin FQ receptor, ORL1

The Journal of pharmacology and experimental therapeutics, 1997-11, Vol.283 (2), p.735

1997

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Identification of potent and highly selective chiral tri-amine and tetra-amine μ opioid receptors ligands: An example of lead optimization using mixture-based libraries

Bioorganic & medicinal chemistry letters, 2006-08, Vol.16 (16), p.4331-4338

2006

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Integrating computational and mixture-based screening of combinatorial libraries

Journal of molecular modeling, 2011-06, Vol.17 (6), p.1473-1482

2011

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Orphanin FQ: Receptor binding and analog structure activity relationships in rat brain

Life sciences (1973), 1996, Vol.59 (1), p.PL23-PL29

1996

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De novo identification of highly active fluorescent kappa opioid ligands from a rhodamine labeled tetrapeptide positional scanning library

Bioorganic & medicinal chemistry letters, 2004-04, Vol.14 (8), p.1947-1951

2004

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Parallel synthesis of bis-oxazole peptidomimetics

Tetrahedron letters, 2013-12, Vol.54 (51), p.7062-7064

2013

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Bis-Cyclic Guanidine Heterocyclic Peptidomimetics as Opioid Ligands with Mixed μ-, κ- and δ-Opioid Receptor Interactions: A Potential Approach to Novel Analgesics

Imaging Dynamic Redox Changes in Mammalian Cells with Green Fluorescent Protein Indicators

Bridging immunogenetics and immunoproteomics: Model positional scanning library analysis for Major Histocompatibility Complex class II DQ in Tursiops truncatus

Mixture-Based Synthetic Combinatorial Libraries

Antinociceptive activity of thiazole-containing cyclized DAMGO and Leu-(Met) enkephalin analogs

Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery

Parallel Synthesis of Hexahydrodiimidazodiazepines Heterocyclic Peptidomimetics and Their in Vitro and in Vivo Activities at μ (MOR), δ (DOR), and κ (KOR) Opioid Receptors

Synthesis and analgesic activity of alkylated, reduced and constrained oligoheterocyclic peptidomimetic analogs of Leu-enkephalin

Identification of Two Novel, Potent, Low-Liability Antinociceptive Compounds from the Direct In Vivo Screening of a Large Mixture-Based Combinatorial Library

A one-pot multicomponent approach to a new series of morphine derivatives and their biological evaluation

Ligand/kappa-opioid receptor interactions: Insights from the X-ray crystal structure

Direct Phenotypic Screening in Mice: Identification of Individual, Novel Antinociceptive Compounds from a Library of 734 821 Pyrrolidine Bis-piperazines

Toxicity of 6-hydroxydopamine: live cell imaging of cytoplasmic redox flux

Fluorescent Mu Selective Opioid Ligands from a Mixture Based Cyclic Peptide Library

A Novel Method for the Determination of Isokinetic Ratios and Its Application in the Synthesis of Two New Positional Scanning Libraries

Use and Implications of the Harmonic Mean Model on Mixtures for Basic Research and Drug Discovery

Conformation-opioid activity relationships of bicyclic guanidines from 3D similarity analysis

The pharmacological properties of a novel MCH1 receptor antagonist isolated from combinatorial libraries

Identification, structure–activity relationships and molecular modeling of potent triamine and piperazine opioid ligands

Binding and in vitro activities of peptides with high affinity for the nociceptin/orphanin FQ receptor, ORL1

Identification of potent and highly selective chiral tri-amine and tetra-amine μ opioid receptors ligands: An example of lead optimization using mixture-based libraries

Integrating computational and mixture-based screening of combinatorial libraries

Orphanin FQ: Receptor binding and analog structure activity relationships in rat brain

De novo identification of highly active fluorescent kappa opioid ligands from a rhodamine labeled tetrapeptide positional scanning library

Parallel synthesis of bis-oxazole peptidomimetics

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