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A Phase 2a randomized, single-center, double-blind, placebo-controlled study to evaluate the safety and preliminary efficacy of oral iOWH032 against cholera diarrhea in a controlled human infection model

PLoS neglected tropical diseases, 2021-11, Vol.15 (11), p.e0009969-e0009969

2021

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Synthesis and biological activities of novel 17-aminogeldanamycin derivatives

Bioorganic & medicinal chemistry, 2004-10, Vol.12 (20), p.5317-5329

2004

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Tandem Action of Glycosyltransferases in the Maturation of Vancomycin and Teicoplanin Aglycones: Novel Glycopeptides

Biochemistry (Easton), 2001-04, Vol.40 (15), p.4745-4755

2001

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Biomimetic Reactions Catalyzed by Cyclodextrins and Their Derivatives

Chemical reviews, 1998-07, Vol.98 (5), p.1997-2012

1998

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Chalcomycin Biosynthesis Gene Cluster from Streptomyces bikiniensis: Novel Features of an Unusual Ketolide Produced through Expression of the chm Polyketide Synthase in Streptomyces fradiae

Antimicrobial Agents and Chemotherapy, 2004-12, Vol.48 (12), p.4703-4712

2004

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Identification of Nuclear Export Inhibitors with Potent Anticancer Activity In vivo

Cancer research (Chicago, Ill.), 2009-01, Vol.69 (2), p.510-517

2009

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Synthesis and evaluation of a new phosphorylated ribavirin prodrug

Antiviral research, 2013-07, Vol.99 (1), p.18-26

2013

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Chemobiosynthesis of Novel 6-Deoxyerythronolide B Analogues by Mutation of the Loading Module of 6-Deoxyerythronolide B Synthase 1

Applied and Environmental Microbiology, 2005-08, Vol.71 (8), p.4503-4509

2005

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The Structural Basis for Induction of VanB Resistance

Journal of the American Chemical Society, 2002-08, Vol.124 (31), p.9064-9065

2002

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The Role of Hydrophobic Substituents in the Biological Activityof Glycopeptide Antibiotics

Journal of the American Chemical Society, 2000-12, Vol.122 (50), p.12608-12609

2000

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Reversal of optical induction in transamination by regioisomeric bifunctionalized cyclodextrins

Bioorganic & medicinal chemistry, 1999-05, Vol.7 (5), p.709-714

1999

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Structural requirements for VanA activity of vancomycin analogues

Tetrahedron, 2002-08, Vol.58 (32), p.6585-6594

2002

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Cyclodextrin-based class I aldolase enzyme mimics to catalyze crossed aldol condensations

Tetrahedron letters, 1998-10, Vol.39 (42), p.7673-7676

1998

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Production of Hybrid 16-Membered Macrolides by Expressing Combinations of Polyketide Synthase Genes in Engineered Streptomyces fradiae Hosts

Chemistry & biology, 2004-10, Vol.11 (10), p.1465-1472

2004

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Incorporation of Glucose Analogs by GtfE and GtfD from the Vancomycin Biosynthetic Pathway to Generate Variant Glycopeptides

Chemistry & biology, 2002-12, Vol.9 (12), p.1305-1314

2002

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Rapid access to epothilone analogs via semisynthetic degradation and reconstruction of epothilone D

Tetrahedron letters, 2004-02, Vol.45 (9), p.1945-1947

2004

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Bifunctional cyclodextrin metalloenzyme mimics

Tetrahedron letters, 1998-12, Vol.39 (51), p.9343-9346

1998

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Further Studies on the Buffer-Catalyzed Cleavage and Isomerization of Uridyluridine. Medium and Ionic Strength Effects on Catalysis by Morpholine, Imidazole, and Acetate Buffers Help Clarify the Mechanisms Involved and Their Relationship to the Mechanism Used by the Enzyme Ribonuclease and by a Ribonuclease Mimic

Journal of the American Chemical Society, 1996-07, Vol.118 (28), p.6588-6600

1996

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ChemInform Abstract: Accessing Expanded Molecular Diversity Through Engineered Biosynthesis of Natural Products

ChemInform, 2008-01, Vol.39 (2), p.no-no

2008

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ChemInform Abstract: Bifunctional Cyclodextrin Metalloenzyme Mimics

ChemInform, 1999-03, Vol.30 (10), p.no-no

1999

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Neonatal activation of the nuclear receptor CAR results in epigenetic memory and permanent change of drug metabolism in mouse liver

Hepatology (Baltimore, Md.), 2012-10, Vol.56 (4), p.1499-1508

2012

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Mechanical Skin Injury Promotes Food Anaphylaxis by Driving Intestinal Mast Cell Expansion

Immunity (Cambridge, Mass.), 2019-05, Vol.50 (5), p.1262-1275.e4

2019

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Exosomal CCL2 from Tubular Epithelial Cells Is Critical for Albumin-Induced Tubulointerstitial Inflammation

Journal of the American Society of Nephrology, 2018-03, Vol.29 (3), p.919-935

2018

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Efficient Generation of Human iPSCs by a Synthetic Self-Replicative RNA

Cell stem cell, 2013-08, Vol.13 (2), p.246-254

2013

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High-throughput, combinatorial synthesis of multimetallic nanoclusters

Proceedings of the National Academy of Sciences - PNAS, 2020-03, Vol.117 (12), p.6316-6322

2020

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A Phase 2a randomized, single-center, double-blind, placebo-controlled study to evaluate the safety and preliminary efficacy of oral iOWH032 against cholera diarrhea in a controlled human infection model

Synthesis and biological activities of novel 17-aminogeldanamycin derivatives

Tandem Action of Glycosyltransferases in the Maturation of Vancomycin and Teicoplanin Aglycones: Novel Glycopeptides

Biomimetic Reactions Catalyzed by Cyclodextrins and Their Derivatives

Chalcomycin Biosynthesis Gene Cluster from Streptomyces bikiniensis: Novel Features of an Unusual Ketolide Produced through Expression of the chm Polyketide Synthase in Streptomyces fradiae

Identification of Nuclear Export Inhibitors with Potent Anticancer Activity In vivo

Synthesis and evaluation of a new phosphorylated ribavirin prodrug

Chemobiosynthesis of Novel 6-Deoxyerythronolide B Analogues by Mutation of the Loading Module of 6-Deoxyerythronolide B Synthase 1

The Structural Basis for Induction of VanB Resistance

The Role of Hydrophobic Substituents in the Biological Activityof Glycopeptide Antibiotics

Reversal of optical induction in transamination by regioisomeric bifunctionalized cyclodextrins

Structural requirements for VanA activity of vancomycin analogues

Cyclodextrin-based class I aldolase enzyme mimics to catalyze crossed aldol condensations

Production of Hybrid 16-Membered Macrolides by Expressing Combinations of Polyketide Synthase Genes in Engineered Streptomyces fradiae Hosts

Incorporation of Glucose Analogs by GtfE and GtfD from the Vancomycin Biosynthetic Pathway to Generate Variant Glycopeptides

Rapid access to epothilone analogs via semisynthetic degradation and reconstruction of epothilone D

Bifunctional cyclodextrin metalloenzyme mimics

ChemInform Abstract: Accessing Expanded Molecular Diversity Through Engineered Biosynthesis of Natural Products

ChemInform Abstract: Bifunctional Cyclodextrin Metalloenzyme Mimics

Neonatal activation of the nuclear receptor CAR results in epigenetic memory and permanent change of drug metabolism in mouse liver

Mechanical Skin Injury Promotes Food Anaphylaxis by Driving Intestinal Mast Cell Expansion

Exosomal CCL2 from Tubular Epithelial Cells Is Critical for Albumin-Induced Tubulointerstitial Inflammation

Efficient Generation of Human iPSCs by a Synthetic Self-Replicative RNA

High-throughput, combinatorial synthesis of multimetallic nanoclusters

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