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Nonstructural Protein 1 of SARS-CoV-2 Is a Potent Pathogenicity Factor Redirecting Host Protein Synthesis Machinery toward Viral RNA

Molecular cell, 2020-12, Vol.80 (6), p.1055-1066.e6

2020

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AAV-mediated direct in vivo CRISPR screen identifies functional suppressors in glioblastoma

Nature neuroscience, 2017-10, Vol.20 (10), p.1329-1341

2017

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Multiplexed activation of endogenous genes by CRISPRa elicits potent antitumor immunity

Nature immunology, 2019-11, Vol.20 (11), p.1494-1505

2019

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Monospecific and bispecific monoclonal SARS-CoV-2 neutralizing antibodies that maintain potency against B.1.617

Nature communications, 2022-03, Vol.13 (1), p.1638-18, Article 1638

2022

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In vivo CRISPR screening in CD8 T cells with AAV–Sleeping Beauty hybrid vectors identifies membrane targets for improving immunotherapy for glioblastoma

Nature biotechnology, 2019-11, Vol.37 (11), p.1302-1313

2019

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Determinants of Divergent Adaptive Immune Responses after Airway Sensitization with Ligands of Toll-Like Receptor 5 or Toll-Like Receptor 9

PloS one, 2016-12, Vol.11 (12), p.e0167693-e0167693

2016

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A genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy

Cell metabolism, 2022-04, Vol.34 (4), p.595-614.e14

2022

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Systematic Immunotherapy Target Discovery Using Genome-Scale In Vivo CRISPR Screens in CD8 T Cells

Cell, 2019-08, Vol.178 (5), p.1189-1204.e23

2019

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High-content CRISPR screening

Nature Reviews Methods Primers, 2022-02, Vol.2 (1), Article 8

2022

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CRISPR-GEMM Pooled Mutagenic Screening Identifies KMT2D as a Major Modulator of Immune Checkpoint Blockade

Cancer discovery, 2020-12, Vol.10 (12), p.1912-1933

2020

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In vivo profiling of metastatic double knockouts through CRISPR-Cpf1 screens

Nature methods, 2019-05, Vol.16 (5), p.405-408

2019

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CTLA-4 tail fusion enhances CAR-T antitumor immunity

Nature immunology, 2023-09, Vol.24 (9), p.1499-1510

2023

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Multiplexed LNP-mRNA vaccination against pathogenic coronavirus species

Cell reports (Cambridge), 2022-08, Vol.40 (5), p.111160-111160, Article 111160

2022

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Flow cytometric gating for spleen monocyte and DC subsets: differences in autoimmune NOD mice and with acute inflammation

Journal of immunological methods, 2016-05, Vol.432, p.4-12

2016

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Tumor immunology CRISPR screening: present, past, and future

Trends in Cancer, 2022-03, Vol.8 (3), p.210-225

2022

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Human Gene Age Dating Reveals an Early and Rapid Evolutionary Construction of the Adaptive Immune System

Genome biology and evolution, 2023-05, Vol.15 (5)

2023

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Mapping a functional cancer genome atlas of tumor suppressors in mouse liver using AAV-CRISPR-mediated direct in vivo screening

Science advances, 2018-02, Vol.4 (2), p.eaao5508-eaao5508

2018

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Diacylglycerol kinase ζ limits B cell antigen receptor-dependent activation of ERK signaling to inhibit early antibody responses

Science signaling, 2013-10, Vol.6 (297), p.ra91

2013

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Despite Increased Type 1 IFN, Autoimmune Nonobese Diabetic Mice Display Impaired Dendritic Cell Response to CpG and Decreased Nuclear Localization of IFN-Activated STAT1

The Journal of immunology (1950), 2016-03, Vol.196 (5), p.2031-2040

2016

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Variant-specific vaccination induces systems immune responses and potent in vivo protection against SARS-CoV-2

Cell reports. Medicine, 2022-05, Vol.3 (5), p.100634, Article 100634

2022

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Interleukin‐2‐mediated inhibition of dendritic cell development correlates with decreased CD135 expression and increased monocyte/macrophage precursors

Immunology, 2014-12, Vol.143 (4), p.640-650

2014

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Convergent Identification and Interrogation of Tumor-Intrinsic Factors that Modulate Cancer Immunity In Vivo

Cell systems, 2019-02, Vol.8 (2), p.136-151.e7

2019

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High-content CRISPR screening

Nature Reviews Methods Primers, 2022-01, Vol.2 (1), Article 9

2022

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Targeting skeletal endothelium to ameliorate bone loss

Nature medicine, 2018-06, Vol.24 (6), p.823-833

2018

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Nonstructural Protein 1 of SARS-CoV-2 Is a Potent Pathogenicity Factor Redirecting Host Protein Synthesis Machinery toward Viral RNA

AAV-mediated direct in vivo CRISPR screen identifies functional suppressors in glioblastoma

Multiplexed activation of endogenous genes by CRISPRa elicits potent antitumor immunity

Monospecific and bispecific monoclonal SARS-CoV-2 neutralizing antibodies that maintain potency against B.1.617

In vivo CRISPR screening in CD8 T cells with AAV–Sleeping Beauty hybrid vectors identifies membrane targets for improving immunotherapy for glioblastoma

Determinants of Divergent Adaptive Immune Responses after Airway Sensitization with Ligands of Toll-Like Receptor 5 or Toll-Like Receptor 9

A genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy

Systematic Immunotherapy Target Discovery Using Genome-Scale In Vivo CRISPR Screens in CD8 T Cells

High-content CRISPR screening

CRISPR-GEMM Pooled Mutagenic Screening Identifies KMT2D as a Major Modulator of Immune Checkpoint Blockade

In vivo profiling of metastatic double knockouts through CRISPR-Cpf1 screens

CTLA-4 tail fusion enhances CAR-T antitumor immunity

Multiplexed LNP-mRNA vaccination against pathogenic coronavirus species

Flow cytometric gating for spleen monocyte and DC subsets: differences in autoimmune NOD mice and with acute inflammation

Tumor immunology CRISPR screening: present, past, and future

Human Gene Age Dating Reveals an Early and Rapid Evolutionary Construction of the Adaptive Immune System

Mapping a functional cancer genome atlas of tumor suppressors in mouse liver using AAV-CRISPR-mediated direct in vivo screening

Diacylglycerol kinase ζ limits B cell antigen receptor-dependent activation of ERK signaling to inhibit early antibody responses

Despite Increased Type 1 IFN, Autoimmune Nonobese Diabetic Mice Display Impaired Dendritic Cell Response to CpG and Decreased Nuclear Localization of IFN-Activated STAT1

Variant-specific vaccination induces systems immune responses and potent in vivo protection against SARS-CoV-2

Interleukin‐2‐mediated inhibition of dendritic cell development correlates with decreased CD135 expression and increased monocyte/macrophage precursors

Convergent Identification and Interrogation of Tumor-Intrinsic Factors that Modulate Cancer Immunity In Vivo

High-content CRISPR screening

Amivantamab in EGFR Exon 20 Insertion-Mutated Non-Small-Cell Lung Cancer Progressing on Platinum Chemotherapy: Initial Results From the CHRYSALIS Phase I Study

Targeting skeletal endothelium to ameliorate bone loss

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