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APPL1: role in adiponectin signaling and beyond

American journal of physiology: endocrinology and metabolism, 2009-01, Vol.296 (1), p.E22-E36

2009

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DsbA-L prevents obesity-induced inflammation and insulin resistance by suppressing the mtDNA release-activated cGAS-cGAMP-STING pathway

Proceedings of the National Academy of Sciences - PNAS, 2017-11, Vol.114 (46), p.12196-12201

2017

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Upregulated TGF-β1 contributes to hyperglycaemia in type 2 diabetes by potentiating glucagon signalling

Diabetologia, 2023-06, Vol.66 (6), p.1142-1155

2023

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Adiponectin Alleviates Diet-Induced Inflammation in the Liver by Suppressing MCP-1 Expression and Macrophage Infiltration

Diabetes (New York, N.Y.), 2021-06, Vol.70 (6), p.1303-1316

2021

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Grb10 Promotes Lipolysis and Thermogenesis by Phosphorylation-Dependent Feedback Inhibition of mTORC1

Cell metabolism, 2014-06, Vol.19 (6), p.967-980

2014

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APPL1 Potentiates Insulin Sensitivity by Facilitating the Binding of IRS1/2 to the Insulin Receptor

Cell reports (Cambridge), 2014-05, Vol.7 (4), p.1227-1238

2014

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APPL1 negatively regulates bone mass, possibly by controlling the fate of bone marrow mesenchymal progenitor cells

Proceedings of the Japan Academy, Series B, 2020/10/09, Vol.96(8), pp.364-371

2020

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Resveratrol Inhibits mTOR Signaling by Promoting the Interaction between mTOR and DEPTOR

The Journal of biological chemistry, 2010-11, Vol.285 (47), p.36387-36394

2010

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Adiponectin signaling and function in insulin target tissues

Journal of molecular cell biology, 2016-04, Vol.8 (2), p.101-109

2016

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Endoplasmic Reticulum (ER) Localization Is Critical for DsbA-L Protein to Suppress ER Stress and Adiponectin Down-regulation in Adipocytes

The Journal of biological chemistry, 2015-04, Vol.290 (16), p.10143-10148

2015

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Adiponectin Inhibits Osteoclastogenesis and Bone Resorption via APPL1-mediated Suppression of Akt1

The Journal of biological chemistry, 2011-04, Vol.286 (14), p.12542-12553

2011

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Adiponectin Activates AMP-activated Protein Kinase in Muscle Cells via APPL1/LKB1-dependent and Phospholipase C/Ca2+/Ca2+/Calmodulin-dependent Protein Kinase Kinase-dependent Pathways

The Journal of biological chemistry, 2009-08, Vol.284 (33), p.22426-22435

2009

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DsbA-L Alleviates Endoplasmic Reticulum Stress-Induced Adiponectin Downregulation

Diabetes (New York, N.Y.), 2010-11, Vol.59 (11), p.2809-2816

2010

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Lack of adiponectin leads to increased lymphocyte activation and increased disease severity in a mouse model of multiple sclerosis

European journal of immunology, 2013-08, Vol.43 (8), p.2089-2100

2013

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Adiponectin Regulates Bone Marrow Mesenchymal Stem Cell Niche Through a Unique Signal Transduction Pathway: An Approach for Treating Bone Disease in Diabetes

Stem cells (Dayton, Ohio), 2015-01, Vol.33 (1), p.240-252

2015

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Central adiponectin administration reveals new regulatory mechanisms of bone metabolism in mice

American journal of physiology: endocrinology and metabolism, 2014-06, Vol.306 (12), p.E1418-E1430

2014

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Alternative splicing variant of the scaffold protein APPL1 suppresses hepatic adiponectin signaling and function

The Journal of biological chemistry, 2018-04, Vol.293 (16), p.6064-6074

2018

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DsbA-L ameliorates high glucose induced tubular damage through maintaining MAM integrity

EBioMedicine, 2019-05, Vol.43, p.607-619

2019

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disulfide-bond A oxidoreductase-like protein (DsbA-L) regulates adiponectin multimerization

Proceedings of the National Academy of Sciences - PNAS, 2008-11, Vol.105 (47), p.18302-18307

2008

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Yin-Yang Regulation of Adiponectin Signaling by APPL Isoforms in Muscle Cells

The Journal of biological chemistry, 2009-11, Vol.284 (46), p.31608-31615

2009

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Hepatic DsbA‐L protects mice from diet‐induced hepatosteatosis and insulin resistance

The FASEB journal, 2017-06, Vol.31 (6), p.2314-2326

2017

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Autophagy-Mediated Insulin Receptor Down-Regulation Contributes to Endoplasmic Reticulum Stress-Induced Insulin Resistance

Molecular pharmacology, 2009-09, Vol.76 (3), p.596-603

2009

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Adiponectin Sensitizes Insulin Signaling by Reducing p70 S6 Kinase-mediated Serine Phosphorylation of IRS-1

The Journal of biological chemistry, 2007-03, Vol.282 (11), p.7991-7996

2007

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Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects

Trends in pharmacological sciences (Regular ed.), 2016-04, Vol.37 (4), p.303-317

2016

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The tumor suppressor TMEM127 regulates insulin sensitivity in a tissue-specific manner

Nature communications, 2019-10, Vol.10 (1), p.4720-17, Article 4720

2019

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APPL1: role in adiponectin signaling and beyond

DsbA-L prevents obesity-induced inflammation and insulin resistance by suppressing the mtDNA release-activated cGAS-cGAMP-STING pathway

Upregulated TGF-β1 contributes to hyperglycaemia in type 2 diabetes by potentiating glucagon signalling

Adiponectin Alleviates Diet-Induced Inflammation in the Liver by Suppressing MCP-1 Expression and Macrophage Infiltration

Grb10 Promotes Lipolysis and Thermogenesis by Phosphorylation-Dependent Feedback Inhibition of mTORC1

APPL1 Potentiates Insulin Sensitivity by Facilitating the Binding of IRS1/2 to the Insulin Receptor

APPL1 negatively regulates bone mass, possibly by controlling the fate of bone marrow mesenchymal progenitor cells

Resveratrol Inhibits mTOR Signaling by Promoting the Interaction between mTOR and DEPTOR

Adiponectin signaling and function in insulin target tissues

Endoplasmic Reticulum (ER) Localization Is Critical for DsbA-L Protein to Suppress ER Stress and Adiponectin Down-regulation in Adipocytes

Adiponectin Inhibits Osteoclastogenesis and Bone Resorption via APPL1-mediated Suppression of Akt1

Adiponectin Activates AMP-activated Protein Kinase in Muscle Cells via APPL1/LKB1-dependent and Phospholipase C/Ca2+/Ca2+/Calmodulin-dependent Protein Kinase Kinase-dependent Pathways

DsbA-L Alleviates Endoplasmic Reticulum Stress-Induced Adiponectin Downregulation

Lack of adiponectin leads to increased lymphocyte activation and increased disease severity in a mouse model of multiple sclerosis

Adiponectin Regulates Bone Marrow Mesenchymal Stem Cell Niche Through a Unique Signal Transduction Pathway: An Approach for Treating Bone Disease in Diabetes

Central adiponectin administration reveals new regulatory mechanisms of bone metabolism in mice

Alternative splicing variant of the scaffold protein APPL1 suppresses hepatic adiponectin signaling and function

DsbA-L ameliorates high glucose induced tubular damage through maintaining MAM integrity

disulfide-bond A oxidoreductase-like protein (DsbA-L) regulates adiponectin multimerization

Yin-Yang Regulation of Adiponectin Signaling by APPL Isoforms in Muscle Cells

Hepatic DsbA‐L protects mice from diet‐induced hepatosteatosis and insulin resistance

Autophagy-Mediated Insulin Receptor Down-Regulation Contributes to Endoplasmic Reticulum Stress-Induced Insulin Resistance

Adiponectin Sensitizes Insulin Signaling by Reducing p70 S6 Kinase-mediated Serine Phosphorylation of IRS-1

Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects

The tumor suppressor TMEM127 regulates insulin sensitivity in a tissue-specific manner

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