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Class II terpene cyclases: structures, mechanisms, and engineering

Natural product reports, 2024-03, Vol.41 (3), p.42-433

2024

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Divergent synthesis of complex diterpenes through a hybrid oxidative approach

Science (American Association for the Advancement of Science), 2020-08, Vol.369 (6505), p.799-806

2020

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Cytochrome P450 Mediated Cyclization in Eunicellane Derived Diterpenoid Biosynthesis

Angewandte Chemie International Edition, 2023-11, Vol.62 (45), p.e202312490

International ed. in English, 2023

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Discovery, Structure, and Engineering of a cis‐Geranylfarnesyl Diphosphate Synthase

Angewandte Chemie International Edition, 2024-07, Vol.63 (27), p.e202401669-n/a

International ed. in English, 2024

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Discovery of the Tiancilactone Antibiotics by Genome Mining of Atypical Bacterial Type II Diterpene Synthases

Chembiochem : a European journal of chemical biology, 2018-08, Vol.19 (16), p.1727-1733

2018

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Antibacterial sulfur-containing platensimycin and platencin congeners from Streptomyces platensis SB12029

Bioorganic & medicinal chemistry, 2016-12, Vol.24 (24), p.6348-6353

2016

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Genome Mining of Streptomyces mobaraensis DSM40847 as a Bleomycin Producer Providing a Biotechnology Platform To Engineer Designer Bleomycin Analogues

Organic letters, 2017-03, Vol.19 (6), p.1386-1389

2017

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Cryptic and Stereospecific Hydroxylation, Oxidation, and Reduction in Platensimycin and Platencin Biosynthesis

Journal of the American Chemical Society, 2019-03, Vol.141 (9), p.4043-4050

2019

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Structure of the ent-Copalyl Diphosphate Synthase PtmT2 from Streptomyces platensis CB00739, a Bacterial Type II Diterpene Synthase

Journal of the American Chemical Society, 2016-08, Vol.138 (34), p.10905-10915

2016

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Characterization and Crystal Structure of a Nonheme Diiron Monooxygenase Involved in Platensimycin and Platencin Biosynthesis

Journal of the American Chemical Society, 2019-08, Vol.141 (31), p.12406-12412

2019

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Discovery and characterization of four glycosyltransferases involved in anthraquinone glycoside biosynthesis in Rubia yunnanensis

Organic chemistry frontiers an international journal of organic chemistry, 2020-09, Vol.7 (17), p.2442-2448

2020

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Deciphering magnesium binding site and structure-function insights in a class II sesquiterpene cyclase

Methods in enzymology, 2024-01, Vol.699, p.25

2024

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Discovery and biosynthesis of bacterial drimane-type sesquiterpenoids from Streptomyces clavuligerus

Beilstein journal of organic chemistry, 2024-04, Vol.20 (1), p.815-822

2024

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Engineered production and evaluation of 6'-deoxy-tallysomycin H-1 revealing new insights into the structure-activity relationship of the anticancer drug bleomycin

Journal of antibiotics, 2018-01, Vol.71 (1), p.97-103

2018

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Isolation and Complete Structural Assignment of Lycopodium Alkaloid Cernupalhine A: Theoretical Prediction and Total Synthesis Validation

Organic letters, 2014-05, Vol.16 (10), p.2700-2703

2014

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Platensimycin and platencin: Inspirations for chemistry, biology, enzymology, and medicine

Biochemical pharmacology, 2017-06, Vol.133, p.139-151

2017

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Lycospidine A, a New Type of Lycopodium Alkaloid from Lycopodium complanatum

Organic letters, 2013-05, Vol.15 (10), p.2438-2441

2013

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Discovery of Diverse Sesquiterpenoids from Crossiella cryophila through Genome Mining and NMR Tracking

Journal of natural products (Washington, D.C.), 2024-02, Vol.87 (2), p.195-206

2024

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Cytochrome P450-Catalyzed Hydroxylation Initiating Ether Formation in Platensimycin Biosynthesis

Journal of the American Chemical Society, 2018-10, Vol.140 (39), p.12349-12353

2018

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Discovery, Structure, and Mechanism of a Class II Sesquiterpene Cyclase

Journal of the American Chemical Society, 2022-12, Vol.144 (48), p.22067-22074

2022

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Biosynthetic Origin of the Ether Ring in Platensimycin

Journal of the American Chemical Society, 2016-12, Vol.138 (51), p.16711-16721

2016

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Two New Indole Alkaloids from Emmenopterys henryi

Helvetica chimica acta, 2013-12, Vol.96 (12), p.2207-2213

2013

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Cytochrome P450-Mediated Skeleton Rearrangement of Taxadiene in an Engineered Escherichia coli System

Organic letters, 2024-03, Vol.26 (8), p.1640-1644

2024

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A Mutasynthetic Library of Platensimycin and Platencin Analogues

Organic letters, 2016-09, Vol.18 (18), p.4606-4609

2016

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Activities of recombinant human bleomycin hydrolase on bleomycins and engineered analogues revealing new opportunities to overcome bleomycin-induced pulmonary toxicity

Bioorganic & medicinal chemistry letters, 2018-09, Vol.28 (16), p.2670-2674

2018

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Class II terpene cyclases: structures, mechanisms, and engineering

Divergent synthesis of complex diterpenes through a hybrid oxidative approach

Cytochrome P450 Mediated Cyclization in Eunicellane Derived Diterpenoid Biosynthesis

Discovery, Structure, and Engineering of a cis‐Geranylfarnesyl Diphosphate Synthase

Discovery of the Tiancilactone Antibiotics by Genome Mining of Atypical Bacterial Type II Diterpene Synthases

Antibacterial sulfur-containing platensimycin and platencin congeners from Streptomyces platensis SB12029

Genome Mining of Streptomyces mobaraensis DSM40847 as a Bleomycin Producer Providing a Biotechnology Platform To Engineer Designer Bleomycin Analogues

Cryptic and Stereospecific Hydroxylation, Oxidation, and Reduction in Platensimycin and Platencin Biosynthesis

Structure of the ent-Copalyl Diphosphate Synthase PtmT2 from Streptomyces platensis CB00739, a Bacterial Type II Diterpene Synthase

Characterization and Crystal Structure of a Nonheme Diiron Monooxygenase Involved in Platensimycin and Platencin Biosynthesis

Discovery and characterization of four glycosyltransferases involved in anthraquinone glycoside biosynthesis in Rubia yunnanensis

Deciphering magnesium binding site and structure-function insights in a class II sesquiterpene cyclase

Discovery and biosynthesis of bacterial drimane-type sesquiterpenoids from Streptomyces clavuligerus

Engineered production and evaluation of 6'-deoxy-tallysomycin H-1 revealing new insights into the structure-activity relationship of the anticancer drug bleomycin

Isolation and Complete Structural Assignment of Lycopodium Alkaloid Cernupalhine A: Theoretical Prediction and Total Synthesis Validation

Platensimycin and platencin: Inspirations for chemistry, biology, enzymology, and medicine

Lycospidine A, a New Type of Lycopodium Alkaloid from Lycopodium complanatum

Discovery of Diverse Sesquiterpenoids from Crossiella cryophila through Genome Mining and NMR Tracking

Cytochrome P450-Catalyzed Hydroxylation Initiating Ether Formation in Platensimycin Biosynthesis

Discovery, Structure, and Mechanism of a Class II Sesquiterpene Cyclase

Biosynthetic Origin of the Ether Ring in Platensimycin

Two New Indole Alkaloids from Emmenopterys henryi

Cytochrome P450-Mediated Skeleton Rearrangement of Taxadiene in an Engineered Escherichia coli System

A Mutasynthetic Library of Platensimycin and Platencin Analogues

Activities of recombinant human bleomycin hydrolase on bleomycins and engineered analogues revealing new opportunities to overcome bleomycin-induced pulmonary toxicity

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