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Comprehensive Analysis of the Human SH3 Domain Family Reveals a Wide Variety of Non-canonical Specificities

Structure (London), 2017-10, Vol.25 (10), p.1598-1610.e3

2017

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The structural basis for selective binding of non-methylated CpG islands by the CFP1 CXXC domain

Nature communications, 2011-03, Vol.2 (1), p.227-227, Article 227

2011

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Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4

Nature communications, 2019-01, Vol.10 (1), p.36-11, Article 36

2019

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Structure and Biochemical Functions of SIRT6

The Journal of biological chemistry, 2011-04, Vol.286 (16), p.14575-14587

2011

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Structure of the catalytic domain of EZH2 reveals conformational plasticity in cofactor and substrate binding sites and explains oncogenic mutations

PloS one, 2013-12, Vol.8 (12), p.e83737

2013

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Discovery of Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase

Journal of medicinal chemistry, 2017-03, Vol.60 (5), p.1876-1891

2017

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(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells

Proceedings of the National Academy of Sciences - PNAS, 2014-09, Vol.111 (35), p.12853-12858

2014

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TP-064, a potent and selective small molecule inhibitor of PRMT4 for multiple myeloma

Oncotarget, 2018-04, Vol.9 (26), p.18480-18493

2018

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Structural basis for the regulatory role of the PPxY motifs in the thioredoxin-interacting protein TXNIP

Biochemical journal, 2016-01, Vol.473 (2), p.179-187

2016

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Chemical basis for the recognition of trimethyllysine by epigenetic reader proteins

Nature communications, 2015-11, Vol.6 (1), p.8911, Article 8911

2015

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Structure-Based Optimization of a Small Molecule Antagonist of the Interaction Between WD Repeat-Containing Protein 5 (WDR5) and Mixed-Lineage Leukemia 1 (MLL1)

Journal of medicinal chemistry, 2016-03, Vol.59 (6), p.2478-2496

2016

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Structural Basis of the Recruitment of Ubiquitin-specific Protease USP15 by Spliceosome Recycling Factor SART3

The Journal of biological chemistry, 2016-08, Vol.291 (33), p.17283-17292

2016

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Structural basis for histone variant H3tK27me3 recognition by PHF1 and PHF19

eLife, 2020-09, Vol.9

2020

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Discovery of a 2,4-Diamino-7-aminoalkoxyquinazoline as a Potent and Selective Inhibitor of Histone Lysine Methyltransferase G9a

Journal of medicinal chemistry, 2009-12, Vol.52 (24), p.7950-7953

2009

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Defining efficient enzyme–cofactor pairs for bioorthogonal profiling of protein methylation

Proceedings of the National Academy of Sciences - PNAS, 2013-10, Vol.110 (42), p.16778-16783

2013

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Molecular Basis for the Regulation of the H3K4 Methyltransferase Activity of PRDM9

Cell reports (Cambridge), 2013-10, Vol.5 (1), p.13-20

2013

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Protein Lysine Methyltransferase G9a Inhibitors: Design, Synthesis, and Structure Activity Relationships of 2,4-Diamino-7-aminoalkoxy-quinazolines

Journal of medicinal chemistry, 2010-08, Vol.53 (15), p.5844-5857

2010

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Structural Basis of Inhibition of the Human NAD+-Dependent Deacetylase SIRT5 by Suramin

Structure (London), 2007-03, Vol.15 (3), p.377-389

2007

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Structural and functional consequences of the STAT5BN642H driver mutation

Nature communications, 2019-06, Vol.10 (1), p.1-15, Article 2517

2019

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A unique binding pocket induced by a noncanonical SAH mimic to develop potent and selective PRMT inhibitors

Acta pharmaceutica Sinica. B, 2023-12, Vol.13 (12), p.4893-4905

2023

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Entropy-driven binding of opioid peptides induces a large domain motion in human dipeptidyl peptidase III

Proceedings of the National Academy of Sciences - PNAS, 2012-04, Vol.109 (17), p.6525-6530

2012

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From study abroad to study at home: Spontaneous neuronal activity predicts depressive symptoms in overseas students during the COVID-19 pandemic

Frontiers in neuroscience, 2023-02, Vol.17, p.1078119-1078119

2023

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Exploiting an Allosteric Binding Site of PRMT3 Yields Potent and Selective Inhibitors

Journal of medicinal chemistry, 2013-03, Vol.56 (5), p.2110-2124

2013

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Comprehensive Analysis of the Human SH3 Domain Family Reveals a Wide Variety of Non-canonical Specificities

The structural basis for selective binding of non-methylated CpG islands by the CFP1 CXXC domain

Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4

Structure and Biochemical Functions of SIRT6

A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells

Structure of the catalytic domain of EZH2 reveals conformational plasticity in cofactor and substrate binding sites and explains oncogenic mutations

Discovery of Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase

(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells

TP-064, a potent and selective small molecule inhibitor of PRMT4 for multiple myeloma

Structural basis for the regulatory role of the PPxY motifs in the thioredoxin-interacting protein TXNIP

Chemical basis for the recognition of trimethyllysine by epigenetic reader proteins

Structure-Based Optimization of a Small Molecule Antagonist of the Interaction Between WD Repeat-Containing Protein 5 (WDR5) and Mixed-Lineage Leukemia 1 (MLL1)

Structural Basis of the Recruitment of Ubiquitin-specific Protease USP15 by Spliceosome Recycling Factor SART3

Structural basis for histone variant H3tK27me3 recognition by PHF1 and PHF19

Discovery of a 2,4-Diamino-7-aminoalkoxyquinazoline as a Potent and Selective Inhibitor of Histone Lysine Methyltransferase G9a

Defining efficient enzyme–cofactor pairs for bioorthogonal profiling of protein methylation

Molecular Basis for the Regulation of the H3K4 Methyltransferase Activity of PRDM9

Protein Lysine Methyltransferase G9a Inhibitors: Design, Synthesis, and Structure Activity Relationships of 2,4-Diamino-7-aminoalkoxy-quinazolines

Structural Basis of Inhibition of the Human NAD+-Dependent Deacetylase SIRT5 by Suramin

Structural and functional consequences of the STAT5BN642H driver mutation

A unique binding pocket induced by a noncanonical SAH mimic to develop potent and selective PRMT inhibitors

Entropy-driven binding of opioid peptides induces a large domain motion in human dipeptidyl peptidase III

From study abroad to study at home: Spontaneous neuronal activity predicts depressive symptoms in overseas students during the COVID-19 pandemic

Exploiting an Allosteric Binding Site of PRMT3 Yields Potent and Selective Inhibitors

A chemical probe of CARM1 alters epigenetic plasticity against breast cancer cell invasion

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