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PARP1 Trapping by PARP Inhibitors Drives Cytotoxicity in Both Cancer Cells and Healthy Bone Marrow

Molecular cancer research, 2019-02, Vol.17 (2), p.409-419

2019

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Mechanistic Dissection of PARP1 Trapping and the Impact on In Vivo Tolerability and Efficacy of PARP Inhibitors

Molecular cancer research, 2015-11, Vol.13 (11), p.1465-1477

2015

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ABBV-176, a PRLR antibody drug conjugate with a potent DNA-damaging PBD cytotoxin and enhanced activity with PARP inhibition

BMC cancer, 2021-06, Vol.21 (1), p.1-681, Article 681

2021

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Discovery of the Poly(ADP-ribose) Polymerase (PARP) Inhibitor 2-[(R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide (ABT-888) for the Treatment of Cancer

Journal of medicinal chemistry, 2009-01, Vol.52 (2), p.514-523

2009

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ABT-888 Confers Broad In vivo Activity in Combination with Temozolomide in Diverse Tumors

Clinical cancer research, 2009-12, Vol.15 (23), p.7277-7290

2009

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Bcl-XL represents a druggable molecular vulnerability during aurora B inhibitor-mediated polyploidization

Proceedings of the National Academy of Sciences - PNAS, 2010-07, Vol.107 (28), p.12634-12639

2010

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Preclinical Characterization of BET Family Bromodomain Inhibitor ABBV-075 Suggests Combination Therapeutic Strategies

Cancer research (Chicago, Ill.), 2017-06, Vol.77 (11), p.2976-2989

2017

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Iniparib Nonselectively Modifies Cysteine-Containing Proteins in Tumor Cells and Is Not a Bona Fide PARP Inhibitor

Clinical cancer research, 2012-01, Vol.18 (2), p.510-523

2012

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The PARP Inhibitor, ABT-888 Potentiates Temozolomide: Correlation with Drug Levels and Reduction in PARP Activity In Vivo

Anticancer research, 2008-09, Vol.28 (5A), p.2625-2635

2008

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Characterization of ABT-806, a Humanized Tumor-Specific Anti-EGFR Monoclonal Antibody

Molecular cancer therapeutics, 2015-05, Vol.14 (5), p.1141-1151

2015

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Synthesis and Evaluation of a New Generation of Orally Efficacious Benzimidazole-Based Poly(ADP-ribose) Polymerase-1 (PARP-1) Inhibitors as Anticancer Agents

Journal of medicinal chemistry, 2009-11, Vol.52 (21), p.6803-6813

2009

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Preclinical activity of ABT-869, a multitargeted receptor tyrosine kinase inhibitor

Molecular cancer therapeutics, 2006-04, Vol.5 (4), p.995-1006

2006

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Discovery and SAR of orally efficacious tetrahydropyridopyridazinone PARP inhibitors for the treatment of cancer

Bioorganic & medicinal chemistry, 2012-08, Vol.20 (15), p.4635-4645

2012

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Discovery and SAR of 2-(1-propylpiperidin-4-yl)-1H-benzimidazole-4-carboxamide: A potent inhibitor of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer

Bioorganic & medicinal chemistry, 2008-07, Vol.16 (14), p.6965-6975

2008

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Preclinical characterization of ABT-348, a kinase inhibitor targeting the aurora, vascular endothelial growth factor receptor/platelet-derived growth factor receptor, and Src kinase families

The Journal of pharmacology and experimental therapeutics, 2012-12, Vol.343 (3), p.617-627

2012

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Pyrazole diaminopyrimidines as dual inhibitors of KDR and Aurora B kinases

Bioorganic & medicinal chemistry letters, 2012-07, Vol.22 (14), p.4750-4755

2012

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Pharmacodynamic Evaluation of Irinotecan Therapy by FDG and FLT PET/CT Imaging in a Colorectal Cancer Xenograft Model

Molecular imaging and biology, 2012-10, Vol.14 (5), p.617-624

2012

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Effect of Sunscreens on UV Radiation-Induced Enhancement of Melanoma Growth in Mice

JNCI : Journal of the National Cancer Institute, 1994-01, Vol.86 (2), p.99-105

1994

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The BCL-2-Selective Inhibitor Venetoclax Spares Activated T-Cells during Anti-Tumor Immunity

Blood, 2018-11, Vol.132 (Supplement 1), p.3704-3704

2018

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Abstract 2783: Empowering therapeutic monoclonal antibodies with IFN-alpha for cancer immunotherapy

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.2783-2783

2018

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Molecular characterization of new melanoma cell lines from C3H mice induced by ethanol plus ultraviolet radiation

Cancer research (Chicago, Ill.), 2003-07, Vol.63 (13), p.3503-3510

2003

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Evidence that the local effect of ultraviolet radiation on the growth of murine melanomas is immunologically mediated

Cancer research (Chicago, Ill.), 1991-08, Vol.51 (16), p.4176-4181

1991

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PARP1 Trapping by PARP Inhibitors Drives Cytotoxicity in Both Cancer Cells and Healthy Bone Marrow

Mechanistic Dissection of PARP1 Trapping and the Impact on In Vivo Tolerability and Efficacy of PARP Inhibitors

ABBV-176, a PRLR antibody drug conjugate with a potent DNA-damaging PBD cytotoxin and enhanced activity with PARP inhibition

Discovery of the Poly(ADP-ribose) Polymerase (PARP) Inhibitor 2-[(R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide (ABT-888) for the Treatment of Cancer

ABT-888 Confers Broad In vivo Activity in Combination with Temozolomide in Diverse Tumors

Bcl-XL represents a druggable molecular vulnerability during aurora B inhibitor-mediated polyploidization

Preclinical Characterization of BET Family Bromodomain Inhibitor ABBV-075 Suggests Combination Therapeutic Strategies

Iniparib Nonselectively Modifies Cysteine-Containing Proteins in Tumor Cells and Is Not a Bona Fide PARP Inhibitor

The PARP Inhibitor, ABT-888 Potentiates Temozolomide: Correlation with Drug Levels and Reduction in PARP Activity In Vivo

Characterization of ABT-806, a Humanized Tumor-Specific Anti-EGFR Monoclonal Antibody

ABT-888, an Orally Active Poly(ADP-Ribose) Polymerase Inhibitor that Potentiates DNA-Damaging Agents in Preclinical Tumor Models

Synthesis and Evaluation of a New Generation of Orally Efficacious Benzimidazole-Based Poly(ADP-ribose) Polymerase-1 (PARP-1) Inhibitors as Anticancer Agents

Preclinical activity of ABT-869, a multitargeted receptor tyrosine kinase inhibitor

Discovery and SAR of orally efficacious tetrahydropyridopyridazinone PARP inhibitors for the treatment of cancer

Discovery and SAR of 2-(1-propylpiperidin-4-yl)-1H-benzimidazole-4-carboxamide: A potent inhibitor of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer

Preclinical characterization of ABT-348, a kinase inhibitor targeting the aurora, vascular endothelial growth factor receptor/platelet-derived growth factor receptor, and Src kinase families

Pyrazole diaminopyrimidines as dual inhibitors of KDR and Aurora B kinases

Pharmacodynamic Evaluation of Irinotecan Therapy by FDG and FLT PET/CT Imaging in a Colorectal Cancer Xenograft Model

Optimization of Phenyl-Substituted Benzimidazole Carboxamide Poly(ADP-Ribose) Polymerase Inhibitors: Identification of (S)-2-(2-Fluoro-4-(pyrrolidin-2-yl)phenyl)-1H-benzimidazole-4-carboxamide (A-966492), a Highly Potent and Efficacious Inhibitor

Effect of Sunscreens on UV Radiation-Induced Enhancement of Melanoma Growth in Mice

The BCL-2-Selective Inhibitor Venetoclax Spares Activated T-Cells during Anti-Tumor Immunity

Abstract 2783: Empowering therapeutic monoclonal antibodies with IFN-alpha for cancer immunotherapy

Molecular characterization of new melanoma cell lines from C3H mice induced by ethanol plus ultraviolet radiation

Optimization of Phenyl-Substituted Benzimidazole Carboxamide Poly(ADP-Ribose) Polymerase Inhibitors: Identification of ( S )-2-(2-Fluoro-4-(pyrrolidin-2-yl)phenyl)-1 H -benzimidazole-4-carboxamide (A-966492), a Highly Potent and Efficacious Inhibitor

Evidence that the local effect of ultraviolet radiation on the growth of murine melanomas is immunologically mediated

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