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Analysis of mammalian cytochrome P450 structure and function by site-directed mutagenesis

Current drug metabolism, 2001-06, Vol.2 (2), p.117

2001

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Phenylalanine and Tryptophan Scanning Mutagenesis of CYP3A4 Substrate Recognition Site Residues and Effect on Substrate Oxidation and Cooperativity

Biochemistry (Easton), 2001-08, Vol.40 (34), p.10150-10160

2001

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The Role of Cytochrome 2B1 Substrate Recognition Site Residues 115, 294, 297, 298, and 362 in the Oxidation of Steroids and 7-Alkoxycoumarins

Archives of biochemistry and biophysics, 2001-10, Vol.394 (1), p.21-28

2001

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cDNA Cloning and Initial Characterization of CYP3A43, a Novel Human Cytochrome P450

Molecular pharmacology, 2001-02, Vol.59 (2), p.386-392

2001

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Dual role of human cytochrome P450 3A4 residue Phe-304 in substrate specificity and cooperativity

The Journal of pharmacology and experimental therapeutics, 2000-05, Vol.293 (2), p.585

2000

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Transcription analysis of the Staphylococcus aureus gene encoding penicillin-binding protein 4

Journal of Bacteriology, 1997-04, Vol.179 (8), p.2651-2657

1997

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Analysis of Staphylococcus aureus genes encoding penicillin-binding protein 4 and an ABC-type transporter

Gene, 1995-12, Vol.167 (1), p.111-113

1995

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Analysis of Four Residues within Substrate Recognition Site 4 of Human Cytochrome P450 3A4: Role in Steroid Hydroxylase Activity and α-Naphthoflavone Stimulation

Archives of biochemistry and biophysics, 1998-02, Vol.350 (2), p.223-232

1998

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Structure-function of cytochromes P450 and flavin-containing monooxygenases: implications for drug metabolism

Drug metabolism and disposition, 1998-12, Vol.26 (12), p.1223

1998

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Identification and functional characterization of eight CYP3A4 protein variants

Pharmacogenetics (London), 2001-07, Vol.11 (5), p.447-458

2001

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Use of the steroid derivative RPR 106541 in combination with site-directed mutagenesis for enhanced cytochrome P-450 3A4 structure/function analysis

The Journal of pharmacology and experimental therapeutics, 1999-08, Vol.290 (2), p.594

1999

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Midazolam Oxidation by Cytochrome P450 3A4 and Active-Site Mutants: an Evaluation of Multiple Binding Sites and of the Metabolic Pathway That Leads to Enzyme Inactivation

Molecular pharmacology, 2002-03, Vol.61 (3), p.495-506

2002

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Structure-function analysis of human cytochrome P-450 2B6 using a novel substrate, site-directed mutagenesis, and molecular modeling

The Journal of pharmacology and experimental therapeutics, 1999-09, Vol.290 (3), p.1141

1999

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Influence of P450 3A4 SRS-2 Residues on Cooperativity and/or Regioselectivity of Aflatoxin B sub(1) Oxidation

Chemical research in toxicology, 2001-05, Vol.14 (5), p.483-491

2001

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Influence of P450 3A4 SRS-2 residues on cooperativity and/or regioselectivity of aflatoxin B(1) oxidation

Chemical research in toxicology, 2001-05, Vol.14 (5), p.483

2001

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Analysis of Staphylococcus aureus genes encoding penicillin-binding protein 4 and an ABC-type transporter

Gene, 1996-01, Vol.167 (1-2), p.111-113

1996

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Extracorporeal cardiopulmonary resuscitation in out-of-hospital cardiac arrest: a registry study

European heart journal, 2020-06, Vol.41 (21), p.1961-1971

2020

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Influence of P450 3A4 SRS-2 Residues on Cooperativity and/or Regioselectivity of Aflatoxin B 1 Oxidation

Chemical research in toxicology, 2001-05, Vol.14 (5), p.483-491

2001

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Epinephrine versus norepinephrine in cardiac arrest patients with post-resuscitation shock

Intensive care medicine, 2022-03, Vol.48 (3), p.300-310

2022

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Should We Perform an Immediate Coronary Angiogram in All Patients After Cardiac Arrest?: Insights From a Large French Registry

JACC. Cardiovascular interventions, 2018-02, Vol.11 (3), p.249-256

2018

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Differential Effect of Targeted Temperature Management Between 32 °C and 36 °C Following Cardiac Arrest According to Initial Severity of Illness: Insights From Two International Data Sets

Chest, 2023-05, Vol.163 (5), p.1120-1129

2023

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Cumulative dose of epinephrine and mode of death after non-shockable out-of-hospital cardiac arrest: a registry-based study

Critical care (London, England), 2023-12, Vol.27 (1), p.496-496, Article 496

2023

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Temporal trends in the use of targeted temperature management after cardiac arrest and association with outcome: insights from the Paris Sudden Death Expertise Centre

Critical care (London, England), 2019-12, Vol.23 (1), p.391-391, Article 391

2019

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Sudden Cardiac Arrest in Young Women

Circulation (New York, N.Y.), 2021-02, Vol.143 (7), p.758-760

2021

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Impact of Coronary Lesion Stability on the Benefit of Emergent Percutaneous Coronary Intervention After Sudden Cardiac Arrest

Circulation. Cardiovascular interventions, 2020-09, Vol.13 (9), p.e009181-e009181

2020

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Analysis of mammalian cytochrome P450 structure and function by site-directed mutagenesis

Phenylalanine and Tryptophan Scanning Mutagenesis of CYP3A4 Substrate Recognition Site Residues and Effect on Substrate Oxidation and Cooperativity

The Role of Cytochrome 2B1 Substrate Recognition Site Residues 115, 294, 297, 298, and 362 in the Oxidation of Steroids and 7-Alkoxycoumarins

cDNA Cloning and Initial Characterization of CYP3A43, a Novel Human Cytochrome P450

Dual role of human cytochrome P450 3A4 residue Phe-304 in substrate specificity and cooperativity

Transcription analysis of the Staphylococcus aureus gene encoding penicillin-binding protein 4

Analysis of Staphylococcus aureus genes encoding penicillin-binding protein 4 and an ABC-type transporter

Analysis of Four Residues within Substrate Recognition Site 4 of Human Cytochrome P450 3A4: Role in Steroid Hydroxylase Activity and α-Naphthoflavone Stimulation

Structure-function of cytochromes P450 and flavin-containing monooxygenases: implications for drug metabolism

Identification and functional characterization of eight CYP3A4 protein variants

Use of the steroid derivative RPR 106541 in combination with site-directed mutagenesis for enhanced cytochrome P-450 3A4 structure/function analysis

Midazolam Oxidation by Cytochrome P450 3A4 and Active-Site Mutants: an Evaluation of Multiple Binding Sites and of the Metabolic Pathway That Leads to Enzyme Inactivation

Structure-function analysis of human cytochrome P-450 2B6 using a novel substrate, site-directed mutagenesis, and molecular modeling

Influence of P450 3A4 SRS-2 Residues on Cooperativity and/or Regioselectivity of Aflatoxin B sub(1) Oxidation

Influence of P450 3A4 SRS-2 residues on cooperativity and/or regioselectivity of aflatoxin B(1) oxidation

Analysis of Staphylococcus aureus genes encoding penicillin-binding protein 4 and an ABC-type transporter

Extracorporeal cardiopulmonary resuscitation in out-of-hospital cardiac arrest: a registry study

Influence of P450 3A4 SRS-2 Residues on Cooperativity and/or Regioselectivity of Aflatoxin B 1 Oxidation

Epinephrine versus norepinephrine in cardiac arrest patients with post-resuscitation shock

Should We Perform an Immediate Coronary Angiogram in All Patients After Cardiac Arrest?: Insights From a Large French Registry

Differential Effect of Targeted Temperature Management Between 32 °C and 36 °C Following Cardiac Arrest According to Initial Severity of Illness: Insights From Two International Data Sets

Cumulative dose of epinephrine and mode of death after non-shockable out-of-hospital cardiac arrest: a registry-based study

Temporal trends in the use of targeted temperature management after cardiac arrest and association with outcome: insights from the Paris Sudden Death Expertise Centre

Sudden Cardiac Arrest in Young Women

Impact of Coronary Lesion Stability on the Benefit of Emergent Percutaneous Coronary Intervention After Sudden Cardiac Arrest

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