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Discovery of Orally Efficacious Tetracyclic Metabotropic Glutamate Receptor 1 (mGluR1) Antagonists for the Treatment of Chronic Pain

Journal of medicinal chemistry, 2007-11, Vol.50 (23), p.5550-5553

2007

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A-ring modification of SCH 900229 and related chromene sulfone γ-secretase inhibitors

Bioorganic & medicinal chemistry letters, 2013-02, Vol.23 (3), p.850-853

2013

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2-Azetidinone Cholesterol Absorption Inhibitors: Structure−Activity Relationships on the Heterocyclic Nucleus

Journal of medicinal chemistry, 1996-09, Vol.39 (19), p.3684-3693

1996

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Design and synthesis of orally efficacious benzimidazoles as melanin-concentrating hormone receptor 1 antagonists

Bioorganic & medicinal chemistry letters, 2006-07, Vol.16 (14), p.3674-3678

2006

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Synthesis of iodinated biochemical tools related to the 2-azetidinone class of cholesterol absorption inhibitors

Bioorganic & medicinal chemistry letters, 2002-02, Vol.12 (3), p.311-314

2002

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SAR of tricyclic sulfones as γ-secretase inhibitors

Science China. Chemistry, 2011-11, Vol.54 (11), p.1688-1701

2011

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Synthesis and structure–activity relationships of piperidine-based melanin-concentrating hormone receptor 1 antagonists

Bioorganic & medicinal chemistry letters, 2006-07, Vol.16 (14), p.3668-3673

2006

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Synthesis and structure–activity relationships of aminoalkylazetidines as ORL1 receptor ligands

Bioorganic & medicinal chemistry letters, 2002-11, Vol.12 (21), p.3157-3160

2002

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Discovery of Novel Tricyclic Heterocycles as Potent and Selective DPP‑4 Inhibitors for the Treatment of Type 2 Diabetes

ACS medicinal chemistry letters, 2016-05, Vol.7 (5), p.498-501

2016

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Scaffold-hopping from xanthines to tricyclic guanines: A case study of dipeptidyl peptidase 4 (DPP4) inhibitors

Bioorganic & medicinal chemistry, 2016-11, Vol.24 (21), p.5534-5545

2016

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A-ring modification of SCH 900229 and related chromene sulfone [gamma]-secretase inhibitors

Bioorganic & medicinal chemistry letters, 2013-02, Vol.23 (3), p.850-853

2013

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Structure activity relationship studies of tricyclic bispyran sulfone γ-secretase inhibitors

Bioorganic & medicinal chemistry letters, 2013-02, Vol.23 (3), p.844-849

2013

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Synthesis and SAR development of novel mGluR1 antagonists for the treatment of chronic pain

Bioorganic & medicinal chemistry letters, 2012-12, Vol.22 (23), p.7223-7226

2012

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Antiulcer agents. 1. Gastric antisecretory and cytoprotective properties of substituted imidazo[1,2-a]pyridines

Journal of medicinal chemistry, 1985-07, Vol.28 (7), p.876-892

1985

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Design and synthesis of tricyclic sulfones as γ-secretase inhibitors with greatly reduced Notch toxicity

Bioorganic & medicinal chemistry letters, 2010-04, Vol.20 (8), p.2591-2596

2010

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Structure activity relationship studies of tricyclic bispyran sulfone [gamma]-secretase inhibitors

Bioorganic & medicinal chemistry letters, 2013-02, Vol.23 (3), p.844-849

2013

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Discovery of SCH 900229, a Potent Presenilin 1 Selective γ-Secretase Inhibitor for the Treatment of Alzheimer’s Disease

ACS medicinal chemistry letters, 2012-11, Vol.3 (11), p.892-896

2012

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Design and synthesis of tricyclic sulfones as g-secretase inhibitors with greatly reduced Notch toxicity

Bioorganic & medicinal chemistry letters, 2010-04, Vol.20 (8), p.2591-2596

2010

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Structure-activity relationships of pyrroloquinazolines as thrombin receptor antagonists

Bioorganic & medicinal chemistry letters, 1999-07, Vol.9 (14), p.2073-2078

1999

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Design and synthesis of tricyclic sulfones as y-secretase inhibitors with greatly reduced Notch toxicity

Bioorganic & medicinal chemistry letters, 2010, Vol.20 (8), p.2591-2596

2010

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Antiinflammatory activity of substituted 6-hydroxypyrimido[2,1-f]purine-2,4,8(1H,3H,9H)-triones. Atypical nonsteroidal antiinflammatory agents

Journal of medicinal chemistry, 1986-06, Vol.29 (6), p.1099-1113

1986

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Trans diastereoselective synthesis of 3-alkyl substituted β-lactams via the acid chloride-imine reaction of nonactivated acid chlorides

Tetrahedron letters, 1995-04, Vol.36 (15), p.2555-2558

1995

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Inhibitors of Acyl CoA:Cholesterol Acyltransferase

Journal of medicinal chemistry, 1996-04, Vol.39 (8), p.1704-1719

1996

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Additions of allylic Grignard reagents to o-allylphenol

Journal of organic chemistry, 1981-09, Vol.46 (19), p.3780-3783

1981

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Substituted (1,2-Diarylethyl)amide Acyl-CoA:Cholesterol Acyltransferase Inhibitors: Effect of Polar Groups on in Vitro and in Vivo Activity

Journal of medicinal chemistry, 1995-05, Vol.38 (10), p.1600-1607

1995

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Discovery of Orally Efficacious Tetracyclic Metabotropic Glutamate Receptor 1 (mGluR1) Antagonists for the Treatment of Chronic Pain

A-ring modification of SCH 900229 and related chromene sulfone γ-secretase inhibitors

2-Azetidinone Cholesterol Absorption Inhibitors: Structure−Activity Relationships on the Heterocyclic Nucleus

Design and synthesis of orally efficacious benzimidazoles as melanin-concentrating hormone receptor 1 antagonists

Synthesis of iodinated biochemical tools related to the 2-azetidinone class of cholesterol absorption inhibitors

SAR of tricyclic sulfones as γ-secretase inhibitors

Synthesis and structure–activity relationships of piperidine-based melanin-concentrating hormone receptor 1 antagonists

Synthesis and structure–activity relationships of aminoalkylazetidines as ORL1 receptor ligands

Discovery of Novel Tricyclic Heterocycles as Potent and Selective DPP‑4 Inhibitors for the Treatment of Type 2 Diabetes

Scaffold-hopping from xanthines to tricyclic guanines: A case study of dipeptidyl peptidase 4 (DPP4) inhibitors

A-ring modification of SCH 900229 and related chromene sulfone [gamma]-secretase inhibitors

Structure activity relationship studies of tricyclic bispyran sulfone γ-secretase inhibitors

Synthesis and SAR development of novel mGluR1 antagonists for the treatment of chronic pain

Antiulcer agents. 1. Gastric antisecretory and cytoprotective properties of substituted imidazo[1,2-a]pyridines

Design and synthesis of tricyclic sulfones as γ-secretase inhibitors with greatly reduced Notch toxicity

Structure activity relationship studies of tricyclic bispyran sulfone [gamma]-secretase inhibitors

Discovery of SCH 900229, a Potent Presenilin 1 Selective γ-Secretase Inhibitor for the Treatment of Alzheimer’s Disease

Design and synthesis of tricyclic sulfones as g-secretase inhibitors with greatly reduced Notch toxicity

Structure-activity relationships of pyrroloquinazolines as thrombin receptor antagonists

Design and synthesis of tricyclic sulfones as y-secretase inhibitors with greatly reduced Notch toxicity

Antiinflammatory activity of substituted 6-hydroxypyrimido[2,1-f]purine-2,4,8(1H,3H,9H)-triones. Atypical nonsteroidal antiinflammatory agents

Trans diastereoselective synthesis of 3-alkyl substituted β-lactams via the acid chloride-imine reaction of nonactivated acid chlorides

Inhibitors of Acyl CoA:Cholesterol Acyltransferase

Additions of allylic Grignard reagents to o-allylphenol

Substituted (1,2-Diarylethyl)amide Acyl-CoA:Cholesterol Acyltransferase Inhibitors: Effect of Polar Groups on in Vitro and in Vivo Activity

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