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Development of Novel, Value-Based, Digital Endpoints for Clinical Trials: A Structured Approach Toward Fit-for-Purpose Validation

Pharmacological reviews, 2020-10, Vol.72 (4), p.899

2020

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Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and Wap-ras transgenic mice

Cancer research (Chicago, Ill.), 1998-11, Vol.58 (21), p.4947-4956

1998

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The use of machine learning improves the assessment of drug-induced driving behaviour

Accident analysis and prevention, 2020-12, Vol.148, p.105822-105822, Article 105822

2020

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Development of Novel, Value-Based, Digital Endpoints for Clinical Trials: A Structured Approach Toward Fit-for-Purpose Validation

Pharmacological reviews, 2020-10, Vol.72 (4), p.899-909

2020

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Using machine learning techniques to characterize sleep-deprived driving behavior

Traffic injury prevention, 2021, Vol.22 (5), p.366-371

2021

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S16.3 Threshold sensitivity to diffuse noxious inhibitory controls depends on electrocutaneous stimulus properties

Clinical neurophysiology, 2011, Vol.122, p.S39-S40

2011

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Tricyclic Farnesyl Protein Transferase Inhibitors: Crystallographic and Calorimetric Studies of Structure−Activity Relationships

Journal of medicinal chemistry, 1999-06, Vol.42 (12), p.2125-2135

1999

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Farnesyl protein transferase inhibition: a novel approach to anti-tumor therapy. the discovery and development of SCH 66336

Current medicinal chemistry, 2001-10, Vol.8 (12), p.1419

2001

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Structure−Activity Relationship of 3-Substituted N-(Pyridinylacetyl)-4- (8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)- piperidine Inhibitors of Farnesyl-Protein Transferase: Design and Synthesis of in Vivo Active Antitumor Compounds

Journal of medicinal chemistry, 1997-12, Vol.40 (26), p.4290-4301

1997

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Biological Effects and Mechanism of Action of Farnesyl Transferase Inhibitors

Chemical research in toxicology, 2000-10, Vol.13 (10), p.949-952

2000

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Potent, Selective, and Orally Bioavailable Tricyclic Pyridyl Acetamide N-Oxide Inhibitors of Farnesyl Protein Transferase with Enhanced in Vivo Antitumor Activity

Journal of medicinal chemistry, 1998-05, Vol.41 (10), p.1561-1567

1998

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Identification of Pharmacokinetically Stable 3,10-Dibromo-8-chlorobenzocycloheptapyridine Farnesyl Protein Transferase Inhibitors with Potent Enzyme and Cellular Activities

Journal of medicinal chemistry, 1999-07, Vol.42 (14), p.2651-2661

1999

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The farnesyl transferase inhibitor SCH 66336 induces a G(2) --> M or G(1) pause in sensitive human tumor cell lines

Experimental cell research, 2001-01, Vol.262 (1), p.17-27

2001

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Effects of SCH 59228, an orally bioavailable farnesyl protein transferase inhibitor, on the growth of oncogene-transformed fibroblasts and a human colon carcinoma xenograft in nude mice

Cancer chemotherapy and pharmacology, 1999, Vol.43 (1), p.50-58

1999

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Antitumor 8-chlorobenzocycloheptapyridines: a new class of selective, nonpeptidic, nonsulfhydryl inhibitors of ras farnesylation

Bioorganic & medicinal chemistry, 1997-01, Vol.5 (1), p.93-99

1997

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Detection and structural characterization of ras oncoprotein-inhibitors complexes by electrospray mass spectrometry

Bioorganic & medicinal chemistry, 1997-05, Vol.5 (5), p.817-820

1997

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Atropisomeric trihalobenzocycloheptapyridine analogues provide stereoselective FPT inhibitors with antitumor activity

Bioorganic & medicinal chemistry, 1999-05, Vol.7 (5), p.861-867

1999

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Responsiveness of electrical nociceptive detection thresholds to capsaicin (8 %)-induced changes in nociceptive processing

Experimental brain research, 2016-09, Vol.234 (9), p.2505-2514

2016

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Inhibition of protein kinase c by the tyrosine kinase inhibitor erbstatin

Biochemical pharmacology, 1990-11, Vol.40 (9), p.2129-2135

1990

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Interaction of a Novel GDP Exchange Inhibitor with the Ras Protein

Biochemistry (Easton), 1998-11, Vol.37 (45), p.15631-15637

1998

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Discovery of novel nonpeptide tricyclic inhibitors of ras farnesyl protein transferase

Bioorganic & medicinal chemistry, 1997-01, Vol.5 (1), p.101-113

1997

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Effect of amiloride on regulatory mechanisms of vascular smooth muscle contraction

Biochemical pharmacology, 1988-03, Vol.37 (5), p.813-818

1988

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Synthesis of C-11 Methyl-Substituted Benzocycloheptapyridine Inhibitors of Farnesyl Protein Transferase

Organic letters, 1999-11, Vol.1 (9), p.1371-1373

1999

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Total synthesis of griseolic acid derivatives from D-glucose

Journal of organic chemistry, 1991-11, Vol.56 (24), p.6819-6822

1991

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1 – 25 von 1.176

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Development of Novel, Value-Based, Digital Endpoints for Clinical Trials: A Structured Approach Toward Fit-for-Purpose Validation

Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and Wap-ras transgenic mice

The use of machine learning improves the assessment of drug-induced driving behaviour

Development of Novel, Value-Based, Digital Endpoints for Clinical Trials: A Structured Approach Toward Fit-for-Purpose Validation

Using machine learning techniques to characterize sleep-deprived driving behavior

S16.3 Threshold sensitivity to diffuse noxious inhibitory controls depends on electrocutaneous stimulus properties

Tricyclic Farnesyl Protein Transferase Inhibitors: Crystallographic and Calorimetric Studies of Structure−Activity Relationships

Farnesyl protein transferase inhibition: a novel approach to anti-tumor therapy. the discovery and development of SCH 66336

Structure−Activity Relationship of 3-Substituted N-(Pyridinylacetyl)-4- (8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)- piperidine Inhibitors of Farnesyl-Protein Transferase: Design and Synthesis of in Vivo Active Antitumor Compounds

Biological Effects and Mechanism of Action of Farnesyl Transferase Inhibitors

Potent, Selective, and Orally Bioavailable Tricyclic Pyridyl Acetamide N-Oxide Inhibitors of Farnesyl Protein Transferase with Enhanced in Vivo Antitumor Activity

Identification of Pharmacokinetically Stable 3,10-Dibromo-8-chlorobenzocycloheptapyridine Farnesyl Protein Transferase Inhibitors with Potent Enzyme and Cellular Activities

The farnesyl transferase inhibitor SCH 66336 induces a G(2) --> M or G(1) pause in sensitive human tumor cell lines

Effects of SCH 59228, an orally bioavailable farnesyl protein transferase inhibitor, on the growth of oncogene-transformed fibroblasts and a human colon carcinoma xenograft in nude mice

Antitumor 8-chlorobenzocycloheptapyridines: a new class of selective, nonpeptidic, nonsulfhydryl inhibitors of ras farnesylation

Inhibitors of Farnesyl Protein Transferase. 4-Amido, 4-Carbamoyl, and 4-Carboxamido Derivatives of 1-(8-Chloro-6,11-dihydro-5H-benzo[5,6]- cyclohepta[1,2-b]pyridin-11-yl)piperazine and 1-(3-Bromo-8-chloro-6,11- dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperazine

Detection and structural characterization of ras oncoprotein-inhibitors complexes by electrospray mass spectrometry

Atropisomeric trihalobenzocycloheptapyridine analogues provide stereoselective FPT inhibitors with antitumor activity

Responsiveness of electrical nociceptive detection thresholds to capsaicin (8 %)-induced changes in nociceptive processing

Inhibition of protein kinase c by the tyrosine kinase inhibitor erbstatin

Interaction of a Novel GDP Exchange Inhibitor with the Ras Protein

Discovery of novel nonpeptide tricyclic inhibitors of ras farnesyl protein transferase

Effect of amiloride on regulatory mechanisms of vascular smooth muscle contraction

Synthesis of C-11 Methyl-Substituted Benzocycloheptapyridine Inhibitors of Farnesyl Protein Transferase

Total synthesis of griseolic acid derivatives from D-glucose

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