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Targeting lactate metabolism for cancer therapeutics

The Journal of clinical investigation, 2013-09, Vol.123 (9), p.3685-3692

2013

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Tristetraprolin Impairs Myc-Induced Lymphoma and Abolishes the Malignant State

Cell, 2012-08, Vol.150 (3), p.563-574

2012

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Blocking Lactate Export by Inhibiting the Myc Target MCT1 Disables Glycolysis and Glutathione Synthesis

Cancer research (Chicago, Ill.), 2014-02, Vol.74 (3), p.908-920

2014

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Aurora kinases A and B are up-regulated by Myc and are essential for maintenance of the malignant state

Blood, 2010-09, Vol.116 (9), p.1498-1505

2010

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Activation of endoplasmic reticulum stress response by enhanced polyamine catabolism is important in the mediation of cisplatin-induced acute kidney injury

PloS one, 2017-09, Vol.12 (9), p.e0184570

2017

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Synthesis and Structure–Activity Relationships of Pteridine Dione and Trione Monocarboxylate Transporter 1 Inhibitors

Journal of medicinal chemistry, 2014-09, Vol.57 (17), p.7317-7324

2014

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Ribosome biogenesis factor Ltv1 chaperones the assembly of the small subunit head

The Journal of cell biology, 2018-12, Vol.217 (12), p.4141-4154

2018

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YAP-Mediated Recruitment of YY1 and EZH2 Represses Transcription of Key Cell-Cycle Regulators

Cancer research (Chicago, Ill.), 2020-06, Vol.80 (12), p.2512-2522

2020

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Hrr25/CK1δ-directed release of Ltv1 from pre-40S ribosomes is necessary for ribosome assembly and cell growth

The Journal of cell biology, 2015-03, Vol.208 (6), p.745-759

2015

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Transgenesis in Xenopus using the Sleeping Beauty transposon system

Developmental dynamics, 2009-07, Vol.238 (7), p.1727-1743

2009

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Expression of Xenopus suppressor of cytokine signaling 3 (xSOCS3) is induced by epithelial wounding

Developmental dynamics, 2005-07, Vol.233 (3), p.1123-1130

2005

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CDK9/cyclin complexes modulate endoderm induction by direct interaction with Mix.3/mixer

Developmental dynamics, 2009-06, Vol.238 (6), p.1346-1357

2009

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Exploiting the co-reliance of tumours upon transport of amino acids and lactate: Gln and Tyr conjugates of MCT1 inhibitors

MedChemComm, 2016-05, Vol.7 (5), p.900-905

2016

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A flk‐1 promoter/enhancer reporter transgenic Xenopus laevis generated using the Sleeping Beauty transposon system: An in vivo model for vascular studies

Developmental dynamics, 2007-10, Vol.236 (10), p.2808-2817

2007

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Targeting lactate metabolism for cancer therapeutics

The Journal of clinical investigation, 2013-09, Vol.123 (9), p.3685

2013

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Hrr25/CK1[delta]-directed release of Ltv1 from pre-40S ribosomes is necessary for ribosome assembly and cell growth

The Journal of cell biology, 2015-03, Vol.208 (6), p.745

2015

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Exploiting the co-reliance of tumours upon transport of amino acids and lactate: Gln and Tyr conjugates of MCT1 inhibitorsThe authors declare no competing interests.Electronic supplementary information (ESI) available: All experimental methods and supporting data for new compounds. See DOI: 10.1039/c5md00579e

2016-05

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Abstract B9: Myc represses Ebf1 and Pax5 to impair early B-cell differentiation and drive progenitor B lymphomagenesis

Cancer research (Chicago, Ill.), 2011-09, Vol.71 (18_Supplement), p.B9-B9

2011

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Abstract 4027: Myc controls mRNA stability through the agency of AU-binding proteins to promote lymphomagenesis

Cancer research (Chicago, Ill.), 2011-04, Vol.71 (8_Supplement), p.4027-4027

2011

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Tristetraprolin is a tumor suppressor that impairs Myc-induced lymphoma and abolishes the malignant state

Cell, 2012-08, Vol.150 (3), p.563-574

2012

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Determination of the minimal domains of Mix.3/Mixer required for endoderm development

Mechanisms of development, 2006-01, Vol.123 (1), p.56-66

2006

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Cell migration and actin organization in cultured human primary, recurrent cutaneous and metastatic melanoma. Time-lapse and image analysis

The American journal of pathology, 1991-08, Vol.139 (2), p.423-435

1991

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10-Year Outcomes after Monitoring, Surgery, or Radiotherapy for Localized Prostate Cancer

The New England journal of medicine, 2016-10, Vol.375 (15), p.1415-1424

2016

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Genome-wide association and functional studies identify a role for IGFBP3 in hip osteoarthritis

Annals of the rheumatic diseases, 2015-10, Vol.74 (10), p.1861-1867

2015

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Flavonoid Content of U.S. Fruits, Vegetables, and Nuts

Journal of agricultural and food chemistry, 2006-12, Vol.54 (26), p.9966-9977

2006

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Targeting lactate metabolism for cancer therapeutics

Tristetraprolin Impairs Myc-Induced Lymphoma and Abolishes the Malignant State

Blocking Lactate Export by Inhibiting the Myc Target MCT1 Disables Glycolysis and Glutathione Synthesis

Aurora kinases A and B are up-regulated by Myc and are essential for maintenance of the malignant state

Activation of endoplasmic reticulum stress response by enhanced polyamine catabolism is important in the mediation of cisplatin-induced acute kidney injury

Synthesis and Structure–Activity Relationships of Pteridine Dione and Trione Monocarboxylate Transporter 1 Inhibitors

Ribosome biogenesis factor Ltv1 chaperones the assembly of the small subunit head

YAP-Mediated Recruitment of YY1 and EZH2 Represses Transcription of Key Cell-Cycle Regulators

Hrr25/CK1δ-directed release of Ltv1 from pre-40S ribosomes is necessary for ribosome assembly and cell growth

Transgenesis in Xenopus using the Sleeping Beauty transposon system

Expression of Xenopus suppressor of cytokine signaling 3 (xSOCS3) is induced by epithelial wounding

CDK9/cyclin complexes modulate endoderm induction by direct interaction with Mix.3/mixer

Exploiting the co-reliance of tumours upon transport of amino acids and lactate: Gln and Tyr conjugates of MCT1 inhibitors

A flk‐1 promoter/enhancer reporter transgenic Xenopus laevis generated using the Sleeping Beauty transposon system: An in vivo model for vascular studies

Targeting lactate metabolism for cancer therapeutics

Hrr25/CK1[delta]-directed release of Ltv1 from pre-40S ribosomes is necessary for ribosome assembly and cell growth

Abstract B9: Myc represses Ebf1 and Pax5 to impair early B-cell differentiation and drive progenitor B lymphomagenesis

Abstract 4027: Myc controls mRNA stability through the agency of AU-binding proteins to promote lymphomagenesis

Tristetraprolin is a tumor suppressor that impairs Myc-induced lymphoma and abolishes the malignant state

Determination of the minimal domains of Mix.3/Mixer required for endoderm development

Cell migration and actin organization in cultured human primary, recurrent cutaneous and metastatic melanoma. Time-lapse and image analysis

10-Year Outcomes after Monitoring, Surgery, or Radiotherapy for Localized Prostate Cancer

Genome-wide association and functional studies identify a role for IGFBP3 in hip osteoarthritis

Flavonoid Content of U.S. Fruits, Vegetables, and Nuts

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