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Protein Tyrosine Phosphatases in Hypothalamic Insulin and Leptin Signaling

Trends in pharmacological sciences (Regular ed.), 2015-10, Vol.36 (10), p.661-674

2015

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Leptin and Insulin Act on POMC Neurons to Promote the Browning of White Fat

Cell, 2015-01, Vol.160 (1-2), p.88-104

2015

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The Thermogenic Effect of Leptin Is Dependent on a Distinct Population of Prolactin-Releasing Peptide Neurons in the Dorsomedial Hypothalamus

Cell metabolism, 2014-10, Vol.20 (4), p.639-649

2014

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Intranasal Targeting of Hypothalamic PTP1B and TCPTP Reinstates Leptin and Insulin Sensitivity and Promotes Weight Loss in Obesity

Cell reports (Cambridge), 2019-09, Vol.28 (11), p.2905-2922.e5

2019

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Leptin Signaling in the Arcuate Nucleus Reduces Insulin’s Capacity to Suppress Hepatic Glucose Production in Obese Mice

Cell reports (Cambridge), 2019-01, Vol.26 (2), p.346-355.e3

2019

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Insulin regulates POMC neuronal plasticity to control glucose metabolism

eLife, 2018-09, Vol.7

2018

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Hepatocyte glutathione peroxidase-1 deficiency improves hepatic glucose metabolism and decreases steatohepatitis in mice

Diabetologia, 2016-12, Vol.59 (12), p.2632-2644

2016

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High-fat-fed obese glutathione peroxidase 1-deficient mice exhibit defective insulin secretion but protection from hepatic steatosis and liver damage

Antioxidants & redox signaling, 2014-05, Vol.20 (14), p.2114

2014

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A Neural basis for Octanoic acid regulation of energy balance

Molecular metabolism (Germany), 2020-04, Vol.34, p.54-71

2020

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Insulin on the brain: The role of central insulin signalling in energy and glucose homeostasis

Journal of neuroendocrinology, 2021-04, Vol.33 (4), p.e12947-n/a

2021

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PTPN2 phosphatase deletion in T cells promotes anti‐tumour immunity and CAR T‐cell efficacy in solid tumours

The EMBO journal, 2020-01, Vol.39 (2), p.e103637-n/a

2020

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TCPTP Regulates Insulin Signalling in AgRP Neurons to Coordinate Glucose Metabolism with Feeding

Diabetes (New York, N.Y.), 2018-07, Vol.67 (7), p.1246-1257

2018

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The peptide hemopressin acts through CB1 cannabinoid receptors to reduce food intake in rats and mice

The Journal of neuroscience, 2010-05, Vol.30 (21), p.7369-7376

2010

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Celastrol Promotes Weight Loss in Diet-Induced Obesity by Inhibiting the Protein Tyrosine Phosphatases PTP1B and TCPTP in the Hypothalamus

Journal of medicinal chemistry, 2018-12, Vol.61 (24), p.11144-11157

2018

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Engineering of a Biologically Active Glycosylated Glucagon-Like Peptide‑1 Analogue

Journal of medicinal chemistry, 2024-05, Vol.67 (9), p.7276-7282

2024

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A Hypothalamic Phosphatase Switch Coordinates Energy Expenditure with Feeding

Cell metabolism, 2017-08, Vol.26 (2), p.375-393.e7

2017

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PTPN2 regulates T cell lineage commitment and αβ versus γδ specification

The Journal of experimental medicine, 2017-09, Vol.214 (9), p.2733-2758

2017

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A Hypothalamic Phosphatase Switch Coordinates Energy Expenditure with Feeding

Cell metabolism, 2017-09, Vol.26 (3), p.577-577

2017

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Insulin signaling in AgRP neurons regulates meal size to limit glucose excursions and insulin resistance

Science advances, 2021-02, Vol.7 (9)

2021

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Central functional response to the novel peptide cannabinoid, hemopressin

Neuropharmacology, 2013-08, Vol.71, p.27-36

2013

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Physiological Roles of GPR10 and PrRP Signaling

Frontiers in endocrinology (Lausanne), 2013, Vol.4, p.20-20

2013

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Erratum to: Hepatocyte glutathione peroxidase-1 deficiency improves hepatic glucose metabolism and decreases steatohepatitis in mice

Diabetologia, 2016-12, Vol.59 (12), p.2729-2729

2016

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Liver-derived extracellular vesicles improve whole-body glycaemic control via inter-organ communication

Nature metabolism, 2024-02, Vol.6 (2), p.254

2024

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Protein Tyrosine Phosphatases in Hypothalamic Insulin and Leptin Signaling

Leptin and Insulin Act on POMC Neurons to Promote the Browning of White Fat

The Thermogenic Effect of Leptin Is Dependent on a Distinct Population of Prolactin-Releasing Peptide Neurons in the Dorsomedial Hypothalamus

Intranasal Targeting of Hypothalamic PTP1B and TCPTP Reinstates Leptin and Insulin Sensitivity and Promotes Weight Loss in Obesity

Leptin Signaling in the Arcuate Nucleus Reduces Insulin’s Capacity to Suppress Hepatic Glucose Production in Obese Mice

Insulin regulates POMC neuronal plasticity to control glucose metabolism

The cytokine GDF15 signals through a population of brainstem cholecystokinin neurons to mediate anorectic signalling

Hepatocyte glutathione peroxidase-1 deficiency improves hepatic glucose metabolism and decreases steatohepatitis in mice

High-fat-fed obese glutathione peroxidase 1-deficient mice exhibit defective insulin secretion but protection from hepatic steatosis and liver damage

A Neural basis for Octanoic acid regulation of energy balance

Insulin on the brain: The role of central insulin signalling in energy and glucose homeostasis

PTPN2 phosphatase deletion in T cells promotes anti‐tumour immunity and CAR T‐cell efficacy in solid tumours

TCPTP Regulates Insulin Signalling in AgRP Neurons to Coordinate Glucose Metabolism with Feeding

The peptide hemopressin acts through CB1 cannabinoid receptors to reduce food intake in rats and mice

Celastrol Promotes Weight Loss in Diet-Induced Obesity by Inhibiting the Protein Tyrosine Phosphatases PTP1B and TCPTP in the Hypothalamus

Engineering of a Biologically Active Glycosylated Glucagon-Like Peptide‑1 Analogue

Phosphoproteomics of three exercise modalities identifies canonical signaling and C18ORF25 as an AMPK substrate regulating skeletal muscle function

A Hypothalamic Phosphatase Switch Coordinates Energy Expenditure with Feeding

PTPN2 regulates T cell lineage commitment and αβ versus γδ specification

A Hypothalamic Phosphatase Switch Coordinates Energy Expenditure with Feeding

Insulin signaling in AgRP neurons regulates meal size to limit glucose excursions and insulin resistance

Central functional response to the novel peptide cannabinoid, hemopressin

Physiological Roles of GPR10 and PrRP Signaling

Erratum to: Hepatocyte glutathione peroxidase-1 deficiency improves hepatic glucose metabolism and decreases steatohepatitis in mice

Liver-derived extracellular vesicles improve whole-body glycaemic control via inter-organ communication

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