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Modeling the receptor pharmacology, pharmacokinetics, and pharmacodynamics of NKTR-214, a kinetically-controlled interleukin-2 (IL2) receptor agonist for cancer immunotherapy

PloS one, 2017-07, Vol.12 (7), p.e0179431

2017

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Bempegaldesleukin (NKTR-214): a CD-122-biased IL-2 receptor agonist for cancer immunotherapy

Expert opinion on biological therapy, 2019-12, Vol.19 (12), p.1223-1228

Doberstein, Stephen K.

2019

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Discovery of a Cytokine and Its Receptor by Functional Screening of the Extracellular Proteome

Science (American Association for the Advancement of Science), 2008-05, Vol.320 (5877), p.807-811

2008

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NKTR-214, an Engineered Cytokine with Biased IL2 Receptor Binding, Increased Tumor Exposure, and Marked Efficacy in Mouse Tumor Models

Clinical cancer research, 2016-02, Vol.22 (3), p.680-690

2016

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SUMMIT-07: a randomized trial of NKTR-181, a new molecular entity, full mu-opioid receptor agonist for chronic low-back pain

Pain (Amsterdam), 2019-06, Vol.160 (6), p.1374-1382

2019

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NKTR-181: A Novel Mu-Opioid Analgesic with Inherently Low Abuse Potential

The Journal of pharmacology and experimental therapeutics, 2017-10, Vol.363 (1), p.104

2017

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Blockade of nonhormonal fibroblast growth factors by FP-1039 inhibits growth of multiple types of cancer

Science translational medicine, 2013-03, Vol.5 (178), p.178ra39

2013

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Long-term Safety and Tolerability of NKTR-181 in Patients with Moderate to Severe Chronic Low Back Pain or Chronic Noncancer Pain: A Phase 3 Multicenter, Open-Label, 52-Week Study (SUMMIT-08 LTS)

Pain medicine (Malden, Mass.), 2020-07, Vol.21 (7), p.1347-1356

2020

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NKTR-358: A novel regulatory T-cell stimulator that selectively stimulates expansion and suppressive function of regulatory T cells for the treatment of autoimmune and inflammatory diseases

Journal of translational autoimmunity (Online), 2021-01, Vol.4, p.100103-100103, Article 100103

2021

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Measuring Opioid Withdrawal in a Phase 3 Study of a New Analgesic, NKTR-181 (Oxycodegol), in Patients with Moderate to Severe Chronic Low Back Pain

Pain medicine (Malden, Mass.), 2020-08, Vol.21 (8), p.1553-1561

2020

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Dominant-Negative Inhibitors of Soluble TNF Attenuate Experimental Arthritis without Suppressing Innate Immunity to Infection

Journal of Immunology, 2007-08, Vol.179 (3), p.1872-1883

2007

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Human Abuse Potential of Oral NKTR-181 in Recreational Opioid Users: A Randomized, Double-Blind, Crossover Study

Pain medicine (Malden, Mass.), 2020-02, Vol.21 (2), p.e114-e126

2020

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Assessment of potentially abuse-related events in two phase 3 studies of NKTR-181, a novel opioid analgesic, using the MADDERS® system (Misuse, Abuse, and Diversion Drug Event Reporting System)

Current medical research and opinion, 2019-09, Vol.35 (9), p.1513-1522

2019

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Abstract 558: Durable antitumor activity of the CD122-biased immunostimulatory cytokine NKTR-214 combined with immune checkpoint blockade

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.558-558

2016

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HTS technologies in biopharmaceutical discovery

Drug discovery today, 2006-08, Vol.11 (15), p.718-724

2006

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Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family

Genes & development, 2001-03, Vol.15 (6), p.672-686

2001

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Genetic analysis of myoblast fusion: blown fuse is required for progression beyond the prefusion complex

The Journal of cell biology, 1997-03, Vol.136 (6), p.1249-1261

1997

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Termination of phototransduction requires binding of the NINAC myosin III and the PDZ protein INAD

Nature neuroscience, 1999-05, Vol.2 (5), p.447-453

1999

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rolling pebbles (rols) is required in Drosophila muscle precursors for recruitment of myoblasts for fusion

Development (Cambridge), 2001-12, Vol.128 (24), p.5061-5073

2001

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Localization and Specificity of the Phospholipid and Actin Binding Sites on the Tail of Acanthamoeba Myosin IC

The Journal of cell biology, 1992-06, Vol.117 (6), p.1241-1249

1992

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Dependence of Calmodulin Localization in the Retina on the NINAC Unconventional Myosin

Science (American Association for the Advancement of Science), 1993-11, Vol.262 (5136), p.1038-1042

1993

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Modeling the receptor pharmacology, pharmacokinetics, and pharmacodynamics of NKTR-214, a kinetically-controlled interleukin-2

PloS one, 2017-07, Vol.12 (7), p.e0179431

2017

Volltextzugriff (PDF)

Immune memory in nonclinical models after treatment with NKTR-214, an engineered cytokine biased towards expansion of CD8+ T cells in tumor

Journal of clinical oncology, 2016-05, Vol.34 (15_suppl), p.11545-11545

2016

Volltextzugriff (PDF)

Abstract 5032: Synergy between an engineered cytokine, NKTR-214, and CTLA-4 blockade in murine colon and breast tumor models

Cancer research (Chicago, Ill.), 2014-10, Vol.74 (19_Supplement), p.5032-5032

2014

Volltextzugriff (PDF)

Combination between a long-acting engineered cytokine (NKTR-214) and checkpoint inhibitors anti-CTLA-4 or anti-PD1 in murine tumor models

Journal of clinical oncology, 2014-05, Vol.32 (15_suppl), p.3082-3082

2014

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Modeling the receptor pharmacology, pharmacokinetics, and pharmacodynamics of NKTR-214, a kinetically-controlled interleukin-2 (IL2) receptor agonist for cancer immunotherapy

Bempegaldesleukin (NKTR-214): a CD-122-biased IL-2 receptor agonist for cancer immunotherapy

Discovery of a Cytokine and Its Receptor by Functional Screening of the Extracellular Proteome

NKTR-214, an Engineered Cytokine with Biased IL2 Receptor Binding, Increased Tumor Exposure, and Marked Efficacy in Mouse Tumor Models

SUMMIT-07: a randomized trial of NKTR-181, a new molecular entity, full mu-opioid receptor agonist for chronic low-back pain

NKTR-181: A Novel Mu-Opioid Analgesic with Inherently Low Abuse Potential

Blockade of nonhormonal fibroblast growth factors by FP-1039 inhibits growth of multiple types of cancer

Long-term Safety and Tolerability of NKTR-181 in Patients with Moderate to Severe Chronic Low Back Pain or Chronic Noncancer Pain: A Phase 3 Multicenter, Open-Label, 52-Week Study (SUMMIT-08 LTS)

NKTR-358: A novel regulatory T-cell stimulator that selectively stimulates expansion and suppressive function of regulatory T cells for the treatment of autoimmune and inflammatory diseases

Measuring Opioid Withdrawal in a Phase 3 Study of a New Analgesic, NKTR-181 (Oxycodegol), in Patients with Moderate to Severe Chronic Low Back Pain

Dominant-Negative Inhibitors of Soluble TNF Attenuate Experimental Arthritis without Suppressing Innate Immunity to Infection

Human Abuse Potential of Oral NKTR-181 in Recreational Opioid Users: A Randomized, Double-Blind, Crossover Study

Assessment of potentially abuse-related events in two phase 3 studies of NKTR-181, a novel opioid analgesic, using the MADDERS® system (Misuse, Abuse, and Diversion Drug Event Reporting System)

Abstract 558: Durable antitumor activity of the CD122-biased immunostimulatory cytokine NKTR-214 combined with immune checkpoint blockade

HTS technologies in biopharmaceutical discovery

Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family

Genetic analysis of myoblast fusion: blown fuse is required for progression beyond the prefusion complex

Termination of phototransduction requires binding of the NINAC myosin III and the PDZ protein INAD

rolling pebbles (rols) is required in Drosophila muscle precursors for recruitment of myoblasts for fusion

Localization and Specificity of the Phospholipid and Actin Binding Sites on the Tail of Acanthamoeba Myosin IC

Dependence of Calmodulin Localization in the Retina on the NINAC Unconventional Myosin

Modeling the receptor pharmacology, pharmacokinetics, and pharmacodynamics of NKTR-214, a kinetically-controlled interleukin-2

Immune memory in nonclinical models after treatment with NKTR-214, an engineered cytokine biased towards expansion of CD8+ T cells in tumor

Abstract 5032: Synergy between an engineered cytokine, NKTR-214, and CTLA-4 blockade in murine colon and breast tumor models

Combination between a long-acting engineered cytokine (NKTR-214) and checkpoint inhibitors anti-CTLA-4 or anti-PD1 in murine tumor models

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