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Development of the Commercial Manufacturing Process for Nirmatrelvir in 17 Months

ACS central science, 2023-05, Vol.9 (5), p.849-857

2023

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Commercial Route Research and Development for SGLT2 Inhibitor Candidate Ertugliflozin

Organic process research & development, 2014-01, Vol.18 (1), p.66-81

2014

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Process Research and Development of an NK-1 Receptor Antagonist. Enantioselective Trifluoromethyl Addition to a Ketone in the Preparation of a Chiral Isochroman

Organic process research & development, 2007-11, Vol.11 (6), p.1015-1024

2007

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Biocatalytic reductive amination from discovery to commercial manufacturing applied to abrocitinib JAK1 inhibitor

Nature catalysis, 2021-09, Vol.4 (9), p.775-782

2021

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Development of a Nitrene-Type Rearrangement for the Commercial Route of the JAK1 Inhibitor Abrocitinib

Organic process research & development, 2021-03, Vol.25 (3), p.608-615

2021

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Synthesis of the C3−C19 Segment of Phorboxazole B

Organic letters, 2005-07, Vol.7 (15), p.3255-3258

2005

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Preparation of a Corticotropin-Releasing Factor Antagonist by Nucleophilic Aromatic Substitution and Copper-Mediated Ether Formation

Organic process research & development, 2009-03, Vol.13 (2), p.324-330

2009

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Ir-Catalyzed Borylation as an Efficient Route to a Nicotine Hapten

Organic process research & development, 2018-04, Vol.22 (4), p.527-534

2018

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Method development and validation of arene substituted regioisomers in a pharmaceutical candidate by high temperature GC-FID

Journal of pharmaceutical and biomedical analysis, 2015-05, Vol.109, p.74-78

2015

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Application of Quantitative 19F and 1H NMR for Reaction Monitoring and In Situ Yield Determinations for an Early Stage Pharmaceutical Candidate

Analytical chemistry (Washington), 2011-11, Vol.83 (22), p.8766-8771

2011

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A practical, efficient, and rapid method for the oxidation of electron deficient pyridines using trifluoroacetic anhydride and hydrogen peroxide–urea complex

Tetrahedron letters, 2000-04, Vol.41 (14), p.2299-2302

2000

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Overriding Innate Decomposition Temperatures of an Avibactam Prodrug Precursor Using Data Science-Guided Synthesis

Organic process research & development, 2024-04, Vol.28 (4), p.1233-1238

2024

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Regioselective Synthesis of an Imidazo[4,5-c]pyridine through Selective Acylation of 3,4-Diaminopyridine: Synthesis of CP-885,316

Organic process research & development, 2006-03, Vol.10 (2), p.257-261

2006

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Synthesis of Nirmatrelvir: Design and Optimization of an Efficient Telescoped Amidation–Dehydration Sequence

Organic process research & development, 2023-12, Vol.27 (12), p.2250-2259

2023

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Synthesis of Nirmatrelvir: Development of an Efficient, Scalable Process to Generate the Western Fragment

Organic process research & development, 2023-12, Vol.27 (12), p.2240-2249

2023

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Process Research and Scale-up of the κ-Opioid Receptor Agonist CJ-15,161 Drug Candidate

Chimia, 2006-01, Vol.60 (9), p.554

2006

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Application of Quantitative ^sup 19^F and ^sup 1^H NMR for Reaction Monitoring and In Situ Yield Determinations for an Early Stage Pharmaceutical Candidate

Analytical chemistry (Washington), 2011-11, Vol.83 (22), p.8766

2011

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Application of Quantitative 19 F and 1 H NMR for Reaction Monitoring and In Situ Yield Determinations for an Early Stage Pharmaceutical Candidate

Analytical chemistry (Washington), 2011-11, Vol.83 (22), p.8766-8771

2011

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Enantioselective Addition of a Trifluoromethyl Anion to Aryl Ketones and Aldehydes

Synthesis (Stuttgart), 2003-01, Vol.2003 (11)

2003

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Alternative Biarylphosphines for Use in the Palladium-Catalyzed Amination of Aryl Halides

Synthesis (Stuttgart), 2003-01, Vol.2003 (11)

2003

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Generation of Bromophenyllithium Reagents from Dibromobenzenes and Addition to Carbonyl and Nitrile Electrophiles

Synlett, 2004-07, Vol.2004 (8), p.1440-1442

2004

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Generation of Bromophenyllithium Reagents from Dibromobenzenes and Addition to Carbonyl and Nitrile Electrophiles

ChemInform, 2004-11, Vol.35 (45), p.no-no

2004

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Enantioselective Addition of a Trifluoromethyl Anion to Aryl Ketones and Aldehydes

ChemInform, 2003-12, Vol.34 (50), p.no-no

2003

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ChemInform Abstract: A Practical, Efficient, and Rapid Method for the Oxidation of Electron-Deficient Pyridines Using Trifluoroacetic Anhydride and Hydrogen Peroxide-Urea Complex

ChemInform, 2000-06, Vol.31 (26), p.no-no

2000

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Alternative Biarylphosphines for Use in the Palladium-Catalyzed Amination of Aryl Halides

ChemInform, 2003-12, Vol.34 (50), p.no-no

2003

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Development of the Commercial Manufacturing Process for Nirmatrelvir in 17 Months

Commercial Route Research and Development for SGLT2 Inhibitor Candidate Ertugliflozin

Process Research and Development of an NK-1 Receptor Antagonist. Enantioselective Trifluoromethyl Addition to a Ketone in the Preparation of a Chiral Isochroman

Biocatalytic reductive amination from discovery to commercial manufacturing applied to abrocitinib JAK1 inhibitor

Development of a Nitrene-Type Rearrangement for the Commercial Route of the JAK1 Inhibitor Abrocitinib

Synthesis of the C3−C19 Segment of Phorboxazole B

Preparation of a Corticotropin-Releasing Factor Antagonist by Nucleophilic Aromatic Substitution and Copper-Mediated Ether Formation

Ir-Catalyzed Borylation as an Efficient Route to a Nicotine Hapten

Method development and validation of arene substituted regioisomers in a pharmaceutical candidate by high temperature GC-FID

Application of Quantitative 19F and 1H NMR for Reaction Monitoring and In Situ Yield Determinations for an Early Stage Pharmaceutical Candidate

A practical, efficient, and rapid method for the oxidation of electron deficient pyridines using trifluoroacetic anhydride and hydrogen peroxide–urea complex

Overriding Innate Decomposition Temperatures of an Avibactam Prodrug Precursor Using Data Science-Guided Synthesis

Regioselective Synthesis of an Imidazo[4,5-c]pyridine through Selective Acylation of 3,4-Diaminopyridine: Synthesis of CP-885,316

Synthesis of Nirmatrelvir: Design and Optimization of an Efficient Telescoped Amidation–Dehydration Sequence

Synthesis of Nirmatrelvir: Development of an Efficient, Scalable Process to Generate the Western Fragment

Process Research and Scale-up of the κ-Opioid Receptor Agonist CJ-15,161 Drug Candidate

Application of Quantitative ^sup 19^F and ^sup 1^H NMR for Reaction Monitoring and In Situ Yield Determinations for an Early Stage Pharmaceutical Candidate

Application of Quantitative 19 F and 1 H NMR for Reaction Monitoring and In Situ Yield Determinations for an Early Stage Pharmaceutical Candidate

Enantioselective Addition of a Trifluoromethyl Anion to Aryl Ketones and Aldehydes

Alternative Biarylphosphines for Use in the Palladium-Catalyzed Amination of Aryl Halides

Generation of Bromophenyllithium Reagents from Dibromobenzenes and Addition to Carbonyl and Nitrile Electrophiles

Generation of Bromophenyllithium Reagents from Dibromobenzenes and Addition to Carbonyl and Nitrile Electrophiles

Enantioselective Addition of a Trifluoromethyl Anion to Aryl Ketones and Aldehydes

ChemInform Abstract: A Practical, Efficient, and Rapid Method for the Oxidation of Electron-Deficient Pyridines Using Trifluoroacetic Anhydride and Hydrogen Peroxide-Urea Complex

Alternative Biarylphosphines for Use in the Palladium-Catalyzed Amination of Aryl Halides

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