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Preserving mitochondria to treat hypertrophic cardiomyopathy: From rare mitochondrial DNA mutation to heart failure therapy?

The Journal of clinical investigation, 2023-07, Vol.133 (14)

Diwan, Abhinav

2023

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Impaired Autophagosome Clearance Contributes to Cardiomyocyte Death in Ischemia/Reperfusion Injury

Circulation (New York, N.Y.), 2012-06, Vol.125 (25), p.3170-3181

2012

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Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion

Proceedings of the National Academy of Sciences - PNAS, 2020-12, Vol.117 (50), p.32105-32113

2020

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Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis

Nature communications, 2017-06, Vol.8 (1), p.15750-15750, Article 15750

2017

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Induction of lysosomal biogenesis in atherosclerotic macrophages can rescue lipid-induced lysosomal dysfunction and downstream sequelae

Arteriosclerosis, thrombosis, and vascular biology, 2014-09, Vol.34 (9), p.1942-1952

2014

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The Case for Restoring Organelles to Treat Ischemic Cardiomyopathy: Is DEPP1 an Attractive Target?

Circulation (New York, N.Y.), 2024-09, Vol.150 (10), p.787-790

Diwan, Abhinav

2024

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Repetitive stimulation of autophagy-lysosome machinery by intermittent fasting preconditions the myocardium to ischemia-reperfusion injury

Autophagy, 2015-09, Vol.11 (9), p.1537-1560

2015

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Come Together: Protein Assemblies, Aggregates and the Sarcostat at the Heart of Cardiac Myocyte Homeostasis

Frontiers in physiology, 2020-06, Vol.11, p.586-586

2020

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Peripheral monocyte-derived cells counter amyloid plaque pathogenesis in a mouse model of Alzheimer's disease

The Journal of clinical investigation, 2022-06, Vol.132 (11)

2022

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Autophagy in Health and Disease

Second edition, 2021

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Enhancing lysosome biogenesis attenuates BNIP3-induced cardiomyocyte death

Autophagy, 2012-03, Vol.8 (3), p.297-309

2012

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MicroRNA-133a Protects Against Myocardial Fibrosis and Modulates Electrical Repolarization Without Affecting Hypertrophy in Pressure-Overloaded Adult Hearts

Circulation research, 2010-01, Vol.106 (1), p.166-175

2010

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Autophagy is impaired in cardiac ischemia-reperfusion injury

Autophagy, 2012-09, Vol.8 (9), p.1394-1396

2012

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Lysosome impairment as a trigger for inflammation in obesity: The proof is in the fat

EBioMedicine, 2020-06, Vol.56, p.102824-102824, Article 102824

2020

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Reciprocal Regulation of Myocardial microRNAs and Messenger RNA in Human Cardiomyopathy and Reversal of the microRNA Signature by Biomechanical Support

Circulation (New York, N.Y.), 2009-03, Vol.119 (9), p.1263-1271

2009

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Decompensation of Cardiac Hypertrophy: Cellular Mechanisms and Novel Therapeutic Targets

Physiology (Bethesda, Md.), 2007-02, Vol.22 (1), p.56-64

2007

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Clinical and Genetic Modifiers of Long-Term Survival in Heart Failure

Journal of the American College of Cardiology, 2009-07, Vol.54 (5), p.432-444

2009

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IRE1 prevents endoplasmic reticulum membrane permeabilization and cell death under pathological conditions

Science signaling, 2015-06, Vol.8 (382), p.ra62

2015

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Dual autonomous mitochondrial cell death pathways are activated by Nix/BNip3L and induce cardiomyopathy

Proceedings of the National Academy of Sciences - PNAS, 2010-05, Vol.107 (20), p.9035-9042

2010

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Transcription Factor EB Activation Rescues Advanced αB-Crystallin Mutation-Induced Cardiomyopathy by Normalizing Desmin Localization

Journal of the American Heart Association, 2019-02, Vol.8 (4), p.e010866-e010866

2019

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TLR4 activation under lipotoxic conditions leads to synergistic macrophage cell death through a TRIF-dependent pathway

The Journal of immunology (1950), 2013-02, Vol.190 (3), p.1285-1296

2013

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Inhibition of ischemic cardiomyocyte apoptosis through targeted ablation of Bnip3 restrains postinfarction remodeling in mice

The Journal of clinical investigation, 2007-10, Vol.117 (10), p.2825-2833

2007

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Tumor necrosis factor receptor-associated factor 2 mediates mitochondrial autophagy

Circulation. Heart failure, 2015-01, Vol.8 (1), p.175-187

2015

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Nix-Mediated Apoptosis Links Myocardial Fibrosis, Cardiac Remodeling, and Hypertrophy Decompensation

Circulation (New York, N.Y.), 2008-01, Vol.117 (3), p.396-404

2008

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Simple nutrients bypass the requirement for HLH-30 in coupling lysosomal nutrient sensing to survival

PLoS biology, 2019-05, Vol.17 (5), p.e3000245-e3000245

2019

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Preserving mitochondria to treat hypertrophic cardiomyopathy: From rare mitochondrial DNA mutation to heart failure therapy?

Impaired Autophagosome Clearance Contributes to Cardiomyocyte Death in Ischemia/Reperfusion Injury

Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion

Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis

Induction of lysosomal biogenesis in atherosclerotic macrophages can rescue lipid-induced lysosomal dysfunction and downstream sequelae

The Case for Restoring Organelles to Treat Ischemic Cardiomyopathy: Is DEPP1 an Attractive Target?

Repetitive stimulation of autophagy-lysosome machinery by intermittent fasting preconditions the myocardium to ischemia-reperfusion injury

Come Together: Protein Assemblies, Aggregates and the Sarcostat at the Heart of Cardiac Myocyte Homeostasis

Peripheral monocyte-derived cells counter amyloid plaque pathogenesis in a mouse model of Alzheimer's disease

Autophagy in Health and Disease

Enhancing lysosome biogenesis attenuates BNIP3-induced cardiomyocyte death

MicroRNA-133a Protects Against Myocardial Fibrosis and Modulates Electrical Repolarization Without Affecting Hypertrophy in Pressure-Overloaded Adult Hearts

Autophagy is impaired in cardiac ischemia-reperfusion injury

Lysosome impairment as a trigger for inflammation in obesity: The proof is in the fat

Reciprocal Regulation of Myocardial microRNAs and Messenger RNA in Human Cardiomyopathy and Reversal of the microRNA Signature by Biomechanical Support

Decompensation of Cardiac Hypertrophy: Cellular Mechanisms and Novel Therapeutic Targets

Clinical and Genetic Modifiers of Long-Term Survival in Heart Failure

IRE1 prevents endoplasmic reticulum membrane permeabilization and cell death under pathological conditions

Dual autonomous mitochondrial cell death pathways are activated by Nix/BNip3L and induce cardiomyopathy

Transcription Factor EB Activation Rescues Advanced αB-Crystallin Mutation-Induced Cardiomyopathy by Normalizing Desmin Localization

TLR4 activation under lipotoxic conditions leads to synergistic macrophage cell death through a TRIF-dependent pathway

Inhibition of ischemic cardiomyocyte apoptosis through targeted ablation of Bnip3 restrains postinfarction remodeling in mice

Tumor necrosis factor receptor-associated factor 2 mediates mitochondrial autophagy

Nix-Mediated Apoptosis Links Myocardial Fibrosis, Cardiac Remodeling, and Hypertrophy Decompensation

Simple nutrients bypass the requirement for HLH-30 in coupling lysosomal nutrient sensing to survival

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