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Molecular imaging in drug development

Nature reviews. Drug discovery, 2008-07, Vol.7 (7), p.591-607

2008

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Discovery and preclinical characterization of [18F]PI-2620, a next-generation tau PET tracer for the assessment of tau pathology in Alzheimer’s disease and other tauopathies

European journal of nuclear medicine and molecular imaging, 2019-09, Vol.46 (10), p.2178-2189

2019

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Aβ imaging with 18F-florbetaben in prodromal Alzheimer's disease: a prospective outcome study

Journal of neurology, neurosurgery and psychiatry, 2015-04, Vol.86 (4), p.431-436

2015

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Comparison of 18F-florbetaben quantification results using the standard Centiloid, MR-based, and MR-less CapAIBL® approaches: Validation against histopathology

Alzheimer's & dementia, 2019-06, Vol.15 (6), p.807-816

2019

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18F-FSPG PET/CT Imaging of System xC- Transporter Activity in Patients with Primary and Metastatic Brain Tumors

Radiology, 2022-06, Vol.303 (3), p.620-631

2022

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18 F-FSPG PET/CT Imaging of System x C - Transporter Activity in Patients with Primary and Metastatic Brain Tumors

Radiology, 2022-06, Vol.303 (3), p.620-631

2022

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Exploratory Clinical Trial of (4S)-4-(3-[18F]fluoropropyl)-L-glutamate for Imaging xC― Transporter Using Positron Emission Tomography in Patients with Non―Small Cell Lung or Breast Cancer

Clinical cancer research, 2012-10, Vol.18 (19), p.5427-5437

2012

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18F-Radiolabeling of Aromatic Compounds Using Triarylsulfonium Salts

European Journal of Organic Chemistry, 2012-02, Vol.2012 (5), p.889-892

2012

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Tau PET imaging with 18 F-PI-2620 in Patients with Alzheimer Disease and Healthy Controls: A First-in-Humans Study

Journal of Nuclear Medicine, 2020-06, Vol.61 (6), p.911-919

2020

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Tau PET imaging with 18F-PI-2620 in Patients with Alzheimer Disease and Healthy Controls: A First-in-Humans Study

The Journal of nuclear medicine (1978), 2020-06, Vol.61 (6), p.911-919

2020

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Evaluation of Dosimetry, Quantitative Methods, and Test–Retest Variability of 18F-PI-2620 PET for the Assessment of Tau Deposits in the Human Brain

The Journal of nuclear medicine (1978), 2020-06, Vol.61 (6), p.920-927

2020

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Evaluation of Dosimetry, Quantitative Methods, and Test-Retest Variability of 18 F-PI-2620 PET for the Assessment of Tau Deposits in the Human Brain

Journal of Nuclear Medicine, 2020-06, Vol.61 (6), p.920-927

2020

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Gene expression levels of matrix metalloproteinases in human atherosclerotic plaques and evaluation of radiolabeled inhibitors as imaging agents for plaque vulnerability

Nuclear medicine and biology, 2014-08, Vol.41 (7), p.562-569

2014

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Commentary to 18F-GP1, a Novel PET Tracer Designed for High-Sensitivity, Low-Background Detection of Thrombi: Imaging Activated Platelets in Clots—Are We Getting There?

Molecular imaging, 2018-01, Vol.17, p.1536012117749052-1536012117749052

2018

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Exploratory Clinical Investigation of (4S)-4-(3-18F-Fluoropropyl)-L-Glutamate PET of Inflammatory and Infectious Lesions

Journal of Nuclear Medicine, 2016-01, Vol.57 (1), p.67-69

2016

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Preclinical evaluation of BAY 1075553, a novel (18)F-labelled inhibitor of prostate-specific membrane antigen for PET imaging of prostate cancer

European journal of nuclear medicine and molecular imaging, 2014-01, Vol.41 (1), p.89

2014

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Small-animal PET of tumor angiogenesis using a (76)Br-labeled human recombinant antibody fragment to the ED-B domain of fibronectin

The Journal of nuclear medicine (1978), 2007-07, Vol.48 (7), p.1172

2007

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18 F-GP1, a Novel PET Tracer Designed for High-Sensitivity, Low-Background Detection of Thrombi

Journal of Nuclear Medicine, 2017-07, Vol.58 (7), p.1094-1099

2017

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(124)I-L19-SIP for immuno-PET imaging of tumour vasculature and guidance of (131)I-L19-SIP radioimmunotherapy

European journal of nuclear medicine and molecular imaging, 2009-08, Vol.36 (8), p.1235

2009

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4-[18F]Fluoroglutamic Acid (BAY 85-8050), a New Amino Acid Radiotracer for PET Imaging of Tumors: Synthesis and in Vitro Characterization

Journal of medicinal chemistry, 2011-01, Vol.54 (1), p.406-410

2011

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Radioimmunotherapy of Solid Tumors by Targeting Extra Domain B Fibronectin: Identification of the Best-Suited Radioimmunoconjugate

Clinical cancer research, 2005-10, Vol.11 (19), p.7053s-7063s

2005

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Investigations into the synthesis, radiofluorination and conjugation of a new [18F]fluorocyclobutyl prosthetic group and its in vitro stability using a tyrosine model system

Bioorganic & medicinal chemistry, 2013-02, Vol.21 (3), p.643-652

2013

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Studies toward the development of new silicon-containing building blocks for the direct (18)F-labeling of peptides

Journal of medicinal chemistry, 2013-10, Vol.56 (19), p.7552-7563

2013

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Design, Synthesis, and Initial Evaluation of a High Affinity Positron Emission Tomography Probe for Imaging Matrix Metalloproteinases 2 and 9

Journal of medicinal chemistry, 2013-06, Vol.56 (12), p.4912-4920

2013

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Molecular imaging in drug development

Discovery and preclinical characterization of [18F]PI-2620, a next-generation tau PET tracer for the assessment of tau pathology in Alzheimer’s disease and other tauopathies

Pilot Preclinical and Clinical Evaluation of (4S)-4-(3-[18F]Fluoropropyl)-L-Glutamate (18F-FSPG) for PET/CT Imaging of Intracranial Malignancies

Aβ imaging with 18F-florbetaben in prodromal Alzheimer's disease: a prospective outcome study

Comparison of 18F-florbetaben quantification results using the standard Centiloid, MR-based, and MR-less CapAIBL® approaches: Validation against histopathology

18F-FSPG PET/CT Imaging of System xC- Transporter Activity in Patients with Primary and Metastatic Brain Tumors

18 F-FSPG PET/CT Imaging of System x C - Transporter Activity in Patients with Primary and Metastatic Brain Tumors

Exploratory Clinical Trial of (4S)-4-(3-[18F]fluoropropyl)-L-glutamate for Imaging xC― Transporter Using Positron Emission Tomography in Patients with Non―Small Cell Lung or Breast Cancer

18F-Radiolabeling of Aromatic Compounds Using Triarylsulfonium Salts

Tau PET imaging with 18 F-PI-2620 in Patients with Alzheimer Disease and Healthy Controls: A First-in-Humans Study

Tau PET imaging with 18F-PI-2620 in Patients with Alzheimer Disease and Healthy Controls: A First-in-Humans Study

Evaluation of Dosimetry, Quantitative Methods, and Test–Retest Variability of 18F-PI-2620 PET for the Assessment of Tau Deposits in the Human Brain

Evaluation of Dosimetry, Quantitative Methods, and Test-Retest Variability of 18 F-PI-2620 PET for the Assessment of Tau Deposits in the Human Brain

Gene expression levels of matrix metalloproteinases in human atherosclerotic plaques and evaluation of radiolabeled inhibitors as imaging agents for plaque vulnerability

Commentary to 18F-GP1, a Novel PET Tracer Designed for High-Sensitivity, Low-Background Detection of Thrombi: Imaging Activated Platelets in Clots—Are We Getting There?

Exploratory Clinical Investigation of (4S)-4-(3-18F-Fluoropropyl)-L-Glutamate PET of Inflammatory and Infectious Lesions

Preclinical evaluation of BAY 1075553, a novel (18)F-labelled inhibitor of prostate-specific membrane antigen for PET imaging of prostate cancer

Small-animal PET of tumor angiogenesis using a (76)Br-labeled human recombinant antibody fragment to the ED-B domain of fibronectin

18 F-GP1, a Novel PET Tracer Designed for High-Sensitivity, Low-Background Detection of Thrombi

(124)I-L19-SIP for immuno-PET imaging of tumour vasculature and guidance of (131)I-L19-SIP radioimmunotherapy

4-[18F]Fluoroglutamic Acid (BAY 85-8050), a New Amino Acid Radiotracer for PET Imaging of Tumors: Synthesis and in Vitro Characterization

Radioimmunotherapy of Solid Tumors by Targeting Extra Domain B Fibronectin: Identification of the Best-Suited Radioimmunoconjugate

Investigations into the synthesis, radiofluorination and conjugation of a new [18F]fluorocyclobutyl prosthetic group and its in vitro stability using a tyrosine model system

Studies toward the development of new silicon-containing building blocks for the direct (18)F-labeling of peptides

Design, Synthesis, and Initial Evaluation of a High Affinity Positron Emission Tomography Probe for Imaging Matrix Metalloproteinases 2 and 9

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