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Small molecules targeting the innate immune cGAS‒STING‒TBK1 signaling pathway

Acta pharmaceutica Sinica. B, 2020-12, Vol.10 (12), p.2272-2298

2020

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Discovery and development of natural product oridonin-inspired anticancer agents

European journal of medicinal chemistry, 2016-10, Vol.122, p.102-117

2016

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Oridonin inhibits hepatic stellate cell proliferation and fibrogenesis

The Journal of surgical research, 2014-07, Vol.190 (1), p.55-63

2014

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Discovery of Indoleamine 2,3-Dioxygenase 1 (IDO-1) Inhibitors Based on Ortho -Naphthaquinone-Containing Natural Product

Molecules (Basel, Switzerland), 2019-03, Vol.24 (6), p.1059

2019

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CYD0281, a Bcl-2 BH4 domain antagonist, inhibits tumor angiogenesis and breast cancer tumor growth

BMC cancer, 2023-05, Vol.23 (1), p.479-479

2023

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Celastrol suppresses colorectal cancer via covalent targeting peroxiredoxin 1

Signal transduction and targeted therapy, 2023-02, Vol.8 (1), p.51-51, Article 51

2023

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Computational drug repositioning for cancer therapeutics

Current topics in medicinal chemistry, 2015-01, Vol.15 (8), p.767

2015

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Modulation of Bax and mTOR for Cancer Therapeutics

Cancer research (Chicago, Ill.), 2017-06, Vol.77 (11), p.3001-3012

2017

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Development of hedgehog pathway inhibitors by epigenetically targeting GLI through BET bromodomain for the treatment of medulloblastoma

Acta pharmaceutica Sinica. B, 2021-02, Vol.11 (2), p.488-504

2021

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A novel STING agonist with systemic and durable anti‐tumour activity

Clinical and translational discovery, 2023-10, Vol.3 (5), p.n/a

2023

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Enhanced effects of novel oridonin analog CYD0682 for hepatic fibrosis

The Journal of surgical research, 2015-12, Vol.199 (2), p.441-449

2015

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InBr3-Catalyzed Glycosidation of Glycals with Arylamines: An Alternative Approach To Access 4-Aminocyclopent-2-enones

Journal of organic chemistry, 2011-04, Vol.76 (8), p.2820-2827

2011

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Medulloblastoma: Molecular understanding, treatment evolution, and new developments

Pharmacology & therapeutics (Oxford), 2020-06, Vol.210, p.107516, Article 107516

2020

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Reactive Glycolysis Metabolite‐Activatable Nanotheranostics for NIR‐II Fluorescence Imaging‐Guided Phototherapy of Cancer

Advanced functional materials, 2022-06, Vol.32 (23), p.n/a

2022

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Piezo-Type Mechanosensitive Ion Channel Component 1 (Piezo1): A Promising Therapeutic Target and Its Modulators

Journal of medicinal chemistry, 2022-05, Vol.65 (9), p.6441-6453

2022

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Synthesis Study on Marmycin A: Preparation of the C3′-Desmethyl Analogues

Journal of organic chemistry, 2009-08, Vol.74 (16), p.6111-6119

2009

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Base-promoted reaction of methyl 4,6- O-benzylidene-3-deoxy-hexopyranosid-2-ulose and various arylamines

Tetrahedron letters, 2011-10, Vol.52 (43), p.5693-5696

2011

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Fragment-based drug design and identification of HJC0123 , a novel orally bioavailable STAT3 inhibitor for cancer therapy

European journal of medicinal chemistry, 2013-04, Vol.62, p.498-507

2013

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Synthesis and Pharmacological Evaluation of 6,7-Indolo/Thiazolo-MorphinansFurther SAR of Levorphanol

Journal of medicinal chemistry, 2007-05, Vol.50 (11), p.2747-2751

2007

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Engineering Oxaliplatin Prodrug Nanoparticles for Second Near‐Infrared Fluorescence Imaging‐Guided Immunotherapy of Colorectal Cancer

Small (Weinheim an der Bergstrasse, Germany), 2021-04, Vol.17 (13), p.e2007882-n/a

2021

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Activatable NIR-II Fluorescent Nanoprobe for Rapid Detection and Imaging of Methylglyoxal Facilitated by the Local Nonpolar Microenvironment

Analytical chemistry (Washington), 2022-01, Vol.94 (2), p.1076-1084

2022

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K2S2O8-promoted direct thiocyanation of pyrazolin-5-ones with ammonium thiocyanate at room temperature

Organic chemistry frontiers an international journal of organic chemistry, 2020-01, Vol.7 (2), p.350-354

2020

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Structural Modification of Natural Product Tanshinone I Leading to Discovery of Novel Nitrogen-Enriched Derivatives with Enhanced Anticancer Profile and Improved Drug-like Properties

Journal of medicinal chemistry, 2018-02, Vol.61 (3), p.760-776

2018

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Theranostic Prodrug Vesicles for Reactive Oxygen Species‐Triggered Ultrafast Drug Release and Local‐Regional Therapy of Metastatic Triple‐Negative Breast Cancer

Advanced functional materials, 2017-12, Vol.27 (46), p.n/a

2017

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Design, Synthesis, and Pharmacological Evaluation of Isoindoline Analogues as New HPK1 Inhibitors

Journal of medicinal chemistry, 2023-12, Vol.66 (23), p.16201-16221

2023

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Small molecules targeting the innate immune cGAS‒STING‒TBK1 signaling pathway

Discovery and development of natural product oridonin-inspired anticancer agents

Oridonin inhibits hepatic stellate cell proliferation and fibrogenesis

Discovery of Indoleamine 2,3-Dioxygenase 1 (IDO-1) Inhibitors Based on Ortho -Naphthaquinone-Containing Natural Product

CYD0281, a Bcl-2 BH4 domain antagonist, inhibits tumor angiogenesis and breast cancer tumor growth

Celastrol suppresses colorectal cancer via covalent targeting peroxiredoxin 1

Computational drug repositioning for cancer therapeutics

Modulation of Bax and mTOR for Cancer Therapeutics

Development of hedgehog pathway inhibitors by epigenetically targeting GLI through BET bromodomain for the treatment of medulloblastoma

A novel STING agonist with systemic and durable anti‐tumour activity

Enhanced effects of novel oridonin analog CYD0682 for hepatic fibrosis

InBr3-Catalyzed Glycosidation of Glycals with Arylamines: An Alternative Approach To Access 4-Aminocyclopent-2-enones

Medulloblastoma: Molecular understanding, treatment evolution, and new developments

Reactive Glycolysis Metabolite‐Activatable Nanotheranostics for NIR‐II Fluorescence Imaging‐Guided Phototherapy of Cancer

Piezo-Type Mechanosensitive Ion Channel Component 1 (Piezo1): A Promising Therapeutic Target and Its Modulators

Synthesis Study on Marmycin A: Preparation of the C3′-Desmethyl Analogues

Base-promoted reaction of methyl 4,6- O-benzylidene-3-deoxy-hexopyranosid-2-ulose and various arylamines

Fragment-based drug design and identification of HJC0123 , a novel orally bioavailable STAT3 inhibitor for cancer therapy

Synthesis and Pharmacological Evaluation of 6,7-Indolo/Thiazolo-MorphinansFurther SAR of Levorphanol

Engineering Oxaliplatin Prodrug Nanoparticles for Second Near‐Infrared Fluorescence Imaging‐Guided Immunotherapy of Colorectal Cancer

Activatable NIR-II Fluorescent Nanoprobe for Rapid Detection and Imaging of Methylglyoxal Facilitated by the Local Nonpolar Microenvironment

K2S2O8-promoted direct thiocyanation of pyrazolin-5-ones with ammonium thiocyanate at room temperature

Structural Modification of Natural Product Tanshinone I Leading to Discovery of Novel Nitrogen-Enriched Derivatives with Enhanced Anticancer Profile and Improved Drug-like Properties

Theranostic Prodrug Vesicles for Reactive Oxygen Species‐Triggered Ultrafast Drug Release and Local‐Regional Therapy of Metastatic Triple‐Negative Breast Cancer

Design, Synthesis, and Pharmacological Evaluation of Isoindoline Analogues as New HPK1 Inhibitors

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