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Inflammatory microenvironment remodelling by tumour cells after radiotherapy

Nature reviews. Cancer, 2020-04, Vol.20 (4), p.203

2020

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ATR Inhibition Potentiates the Radiation-induced Inflammatory Tumor Microenvironment

Clinical cancer research, 2019-06, Vol.25 (11), p.3392-3403

2019

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Radiosensitization by the ATR Inhibitor AZD6738 through Generation of Acentric Micronuclei

Molecular cancer therapeutics, 2017-01, Vol.16 (1), p.25-34

2017

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Human Papillomavirus-Negative Pharyngeal Cancer

Journal of clinical oncology, 2015-10, Vol.33 (29), p.3251-3261

2015

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Patritumab or placebo, with cetuximab plus platinum therapy in recurrent or metastatic squamous cell carcinoma of the head and neck: A randomised phase II study

European journal of cancer (1990), 2019-12, Vol.123, p.36-47

2019

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Harnessing radiotherapy-induced NK-cell activity by combining DNA damage–response inhibition and immune checkpoint blockade

Journal for immunotherapy of cancer, 2022-03, Vol.10 (3), p.e004306

2022

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Durable responses to ATR inhibition with ceralasertib in tumors with genomic defects and high inflammation

The Journal of clinical investigation, 2024-01, Vol.134 (2), p.1-14

2024

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PD-1 Blockade Following Isolated Limb Perfusion with Vaccinia Virus Prevents Local and Distant Relapse of Soft-tissue Sarcoma

Clinical cancer research, 2019-06, Vol.25 (11), p.3443-3454

2019

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Combined ATR and DNA-PK Inhibition Radiosensitizes Tumor Cells Independently of Their p53 Status

Frontiers in oncology, 2018-07, Vol.8, p.245-245

2018

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An orally bioavailable Chk1 inhibitor, CCT244747, sensitizes bladder and head and neck cancer cell lines to radiation

Radiotherapy and oncology, 2017-03, Vol.122 (3), p.470-475

2017

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Patritumab with Cetuximab plus Platinum-Containing Therapy in Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck: An Open-Label, Phase Ib Study

Clinical cancer research, 2019-01, Vol.25 (2), p.487-495

2019

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The PERK Inhibitor GSK2606414 Enhances Reovirus Infection in Head and Neck Squamous Cell Carcinoma via an ATF4-Dependent Mechanism

Molecular therapy. Oncolytics, 2020-03, Vol.16, p.238-249

2020

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Differential and longitudinal immune gene patterns associated with reprogrammed microenvironment and viral mimicry in response to neoadjuvant radiotherapy in rectal cancer

Journal for immunotherapy of cancer, 2021-03, Vol.9 (3), p.e001717

2021

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A role for squamous metaplasia in COPD airway obstruction

Thorax, 2008-03, Vol.63 (3), p.258

Dillon, Magnus

2008

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Abstract LB-104: Quantification of the preclinical and clinical relationship between pRAD50 and efficacy after treatment with the ATR inhibitor ceralasertib (AZD6738)

Cancer research (Chicago, Ill.), 2020-08, Vol.80 (16_Supplement), p.LB-104-LB-104

2020

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HSP90 inhibition sensitizes head and neck cancer to platin-based chemoradiotherapy by modulation of the DNA damage response resulting in chromosomal fragmentation

BMC cancer, 2017-01, Vol.17 (1), p.86, Article 86

2017

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Patritumab (P) or placebo (PBO) plus cetuximab (C) and platinum-based therapy in squamous cell carcinoma of the head and neck (SCCHN): a phase 2 study

Journal of clinical oncology, 2016-05, Vol.34 (15_suppl), p.TPS6104-TPS6104

2016

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Abstract CT084: A Phase I dose-escalation study of ATR inhibitor monotherapy with AZD6738 in advanced solid tumors (PATRIOT Part A)

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.CT084-CT084

2017

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PATRIOT: A phase I study to assess the tolerability, safety and biological effects of a specific ataxia telangiectasia and Rad3-related (ATR) inhibitor (AZD6738) as a single agent and in combination with palliative radiation therapy in patients with solid tumours

Journal of clinical oncology, 2016-05, Vol.34 (15_suppl), p.TPS2603-TPS2603

2016

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Targeting ATR for Cancer Therapy: ATR-Targeted Drug Candidates

Targeting the DNA Damage Response for Anti-Cancer Therapy, 2018, p.99-127

2018

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Biologically Targeted Agents in Head and Neck Cancers

Head & Neck Surgery Plastic Surgery, 2019, Vol.3, p.483-497

8, 2019

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Antimicrobial resistance in Neisseria gonorrhoeae: Global surveillance and a call for international collaborative action

PLoS medicine, 2017-07, Vol.14 (7), p.e1002344

2017

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World Health Organization Global Gonococcal Antimicrobial Surveillance Program (WHO GASP): review of new data and evidence to inform international collaborative actions and research efforts

Sexual health, 2019-01, Vol.16 (5), p.412

2019

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Review and International Recommendation of Methods for Typing Neisseria gonorrhoeae Isolates and Their Implications for Improved Knowledge of Gonococcal Epidemiology, Treatment, and Biology

Clinical Microbiology Reviews, 2011-07, Vol.24 (3), p.447-458

2011

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Inflammatory microenvironment remodelling by tumour cells after radiotherapy

ATR Inhibition Potentiates the Radiation-induced Inflammatory Tumor Microenvironment

Radiosensitization by the ATR Inhibitor AZD6738 through Generation of Acentric Micronuclei

Human Papillomavirus-Negative Pharyngeal Cancer

Patritumab or placebo, with cetuximab plus platinum therapy in recurrent or metastatic squamous cell carcinoma of the head and neck: A randomised phase II study

Harnessing radiotherapy-induced NK-cell activity by combining DNA damage–response inhibition and immune checkpoint blockade

Durable responses to ATR inhibition with ceralasertib in tumors with genomic defects and high inflammation

PD-1 Blockade Following Isolated Limb Perfusion with Vaccinia Virus Prevents Local and Distant Relapse of Soft-tissue Sarcoma

Combined ATR and DNA-PK Inhibition Radiosensitizes Tumor Cells Independently of Their p53 Status

Predicting progression-free survival after systemic therapy in advanced head and neck cancer: Bayesian regression and model development

An orally bioavailable Chk1 inhibitor, CCT244747, sensitizes bladder and head and neck cancer cell lines to radiation

Patritumab with Cetuximab plus Platinum-Containing Therapy in Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck: An Open-Label, Phase Ib Study

The PERK Inhibitor GSK2606414 Enhances Reovirus Infection in Head and Neck Squamous Cell Carcinoma via an ATF4-Dependent Mechanism

Differential and longitudinal immune gene patterns associated with reprogrammed microenvironment and viral mimicry in response to neoadjuvant radiotherapy in rectal cancer

A role for squamous metaplasia in COPD airway obstruction

Abstract LB-104: Quantification of the preclinical and clinical relationship between pRAD50 and efficacy after treatment with the ATR inhibitor ceralasertib (AZD6738)

HSP90 inhibition sensitizes head and neck cancer to platin-based chemoradiotherapy by modulation of the DNA damage response resulting in chromosomal fragmentation

Patritumab (P) or placebo (PBO) plus cetuximab (C) and platinum-based therapy in squamous cell carcinoma of the head and neck (SCCHN): a phase 2 study

Abstract CT084: A Phase I dose-escalation study of ATR inhibitor monotherapy with AZD6738 in advanced solid tumors (PATRIOT Part A)

PATRIOT: A phase I study to assess the tolerability, safety and biological effects of a specific ataxia telangiectasia and Rad3-related (ATR) inhibitor (AZD6738) as a single agent and in combination with palliative radiation therapy in patients with solid tumours

Targeting ATR for Cancer Therapy: ATR-Targeted Drug Candidates

Biologically Targeted Agents in Head and Neck Cancers

Antimicrobial resistance in Neisseria gonorrhoeae: Global surveillance and a call for international collaborative action

World Health Organization Global Gonococcal Antimicrobial Surveillance Program (WHO GASP): review of new data and evidence to inform international collaborative actions and research efforts

Review and International Recommendation of Methods for Typing Neisseria gonorrhoeae Isolates and Their Implications for Improved Knowledge of Gonococcal Epidemiology, Treatment, and Biology

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