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Structure-Based Design of β‑Site APP Cleaving Enzyme 1 (BACE1) Inhibitors for the Treatment of Alzheimer’s Disease

Journal of medicinal chemistry, 2013-06, Vol.56 (11), p.4156-4180

2013

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Effects of the bace1 inhibitor bi 1181181 and the anti-abeta antibody m266 on abeta in rat brain homogenate and CSF

Alzheimer's & dementia, 2015-07, Vol.11 (7), p.P843-P843

2015

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Pharmacological characterization of the new bace1 inhibitor bi 1181181

Alzheimer's & dementia, 2015-07, Vol.11 (7), p.P477-P477

2015

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Synthesis of 2-amino-5-benzoyl-4-(2-furyl)thiazoles as adenosine A(2A) receptor antagonists

Bioorganic & medicinal chemistry letters, 2009-01, Vol.19 (2), p.378-381

2009

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Synthesis of 2-amino-5-benzoyl-4-(2-furyl)thiazoles as adenosine A2A receptor antagonists

Bioorganic & medicinal chemistry letters, 2009-01, Vol.19 (2), p.378-381

2009

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Complex Synthetic Chemical Libraries Indexed with Molecular Tags

Proceedings of the National Academy of Sciences - PNAS, 1993-12, Vol.90 (23), p.10922-10926

1993

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Optimization of orally bioavailable alkyl amine renin inhibitors

Bioorganic & medicinal chemistry letters, 2010-01, Vol.20 (2), p.694-699

2010

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Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility

ACS medicinal chemistry letters, 2011-10, Vol.2 (10), p.747-751

2011

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Biphenyl/diphenyl ether renin inhibitors: Filling the S1 pocket of renin via the S3 pocket

Bioorganic & medicinal chemistry letters, 2011-08, Vol.21 (16), p.4836-4843

2011

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Design and optimization of renin inhibitors: Orally bioavailable alkyl amines

Bioorganic & medicinal chemistry, 2009-07, Vol.19 (13), p.3541-3545

2009

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Cloning, Characterization and Site-Directed Mutagenesis of Canine Renin

Journal of biochemistry (Tokyo), 2007-12, Vol.142 (6), p.671-680

2007

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Stereospecific total syntheses of decahydroquinoline alkaloids (.+-.)-195A and (.+-.)-2-epi-195A

Journal of organic chemistry, 1992-07, Vol.57 (15), p.4103-4110

1992

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The potent, selective RORγt blocker, VTP-43742, suppresses Th17 production in vivo and provides greater benefit than IL-17 blockade in the EAE model of autoimmunity (THER3P.968)

The Journal of immunology (1950), 2015-05, Vol.194 (1_Supplement), p.68-68.1

2015

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P4‐168: Effects of the bace1 inhibitor bi 1181181 and the anti‐abeta antibody m266 on abeta in rat brain homogenate and CSF

Alzheimer's & dementia, 2015-07, Vol.11 (7S_Part_18), p.P843-P843

2015

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VTP-43742 is a potent and selective RORγt blocker that demonstrates oral efficacy in a mouse model of autoimmunity through suppression of IL-17A production (THER7P.945)

The Journal of immunology (1950), 2015-05, Vol.194 (1_Supplement), p.208-208.5|68.3

2015

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P1‐314: Pharmacological characterization of the new bace1 inhibitor bi 1181181

Alzheimer's & dementia, 2015-07, Vol.11 (7S_Part_10), p.P477-P477

2015

Volltextzugriff (PDF)

Synthesis of 2-amino-5-benzoyl-4-(2-furyl)thiazoles as adenosine A 2A receptor antagonists

Bioorganic & medicinal chemistry letters, 2009, Vol.19 (2), p.378-381

2009

Volltextzugriff (PDF)

Diastereoselective addition of organometallic reagents to chiral iminium ions: Synthesis of ( S)-(+)-cryptostyline I

Tetrahedron letters, 1990, Vol.31 (6), p.797-800

1990

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A Paradigm for Drug Discovery Employing Encoded Combinatorial Libraries

Proceedings of the National Academy of Sciences - PNAS, 1995-06, Vol.92 (13), p.6027-6031

1995

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Combinatorial Libraries Encoded with Electrophoric Tags

European journal of medicinal chemistry, 1995, Vol.30, p.349s-358s

1995

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I.~Diastereoselective addition of Grignard reagents to chiral iminium ions: Total synthesis of (S)-(+)-cryptostyline I. II.~Stereospecific total syntheses of decahydroquinoline alkaloids (+,-)-195A and (+,-)-2-epi-195A

Dillard, Lawrence Wayne

1992

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Binary encoded small-molecule libraries in drug discovery and optimization

Perspectives in drug discovery and design, 1995-04, Vol.2 (2), p.305-318

1995

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OPERATING LOSS CARRYFORWARDS FOR FIRMS WITH DEFERRED TAX CREDITS

MAPLES, LAWRENCE DILLARD

1976

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High Throughput Analysis of Combinatorial Libraries Encoded with Electrophoric Molecular Tags

High Throughput Analysis for Early Drug Discovery, 2004

Kyranos, James

2004

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1 - High Throughput Analysis of Combinatorial Libraries Encoded with Electrophoric Molecular Tags

High Throughput Analysis for Early Drug Discovery, 2004, p.1-36

2004

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Structure-Based Design of β‑Site APP Cleaving Enzyme 1 (BACE1) Inhibitors for the Treatment of Alzheimer’s Disease

Effects of the bace1 inhibitor bi 1181181 and the anti-abeta antibody m266 on abeta in rat brain homogenate and CSF

Pharmacological characterization of the new bace1 inhibitor bi 1181181

Synthesis of 2-amino-5-benzoyl-4-(2-furyl)thiazoles as adenosine A(2A) receptor antagonists

Synthesis of 2-amino-5-benzoyl-4-(2-furyl)thiazoles as adenosine A2A receptor antagonists

Complex Synthetic Chemical Libraries Indexed with Molecular Tags

Optimization of orally bioavailable alkyl amine renin inhibitors

Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility

Biphenyl/diphenyl ether renin inhibitors: Filling the S1 pocket of renin via the S3 pocket

Design and optimization of renin inhibitors: Orally bioavailable alkyl amines

Cloning, Characterization and Site-Directed Mutagenesis of Canine Renin

Stereospecific total syntheses of decahydroquinoline alkaloids (.+-.)-195A and (.+-.)-2-epi-195A

The potent, selective RORγt blocker, VTP-43742, suppresses Th17 production in vivo and provides greater benefit than IL-17 blockade in the EAE model of autoimmunity (THER3P.968)

P4‐168: Effects of the bace1 inhibitor bi 1181181 and the anti‐abeta antibody m266 on abeta in rat brain homogenate and CSF

VTP-43742 is a potent and selective RORγt blocker that demonstrates oral efficacy in a mouse model of autoimmunity through suppression of IL-17A production (THER7P.945)

P1‐314: Pharmacological characterization of the new bace1 inhibitor bi 1181181

Synthesis of 2-amino-5-benzoyl-4-(2-furyl)thiazoles as adenosine A 2A receptor antagonists

Diastereoselective addition of organometallic reagents to chiral iminium ions: Synthesis of ( S)-(+)-cryptostyline I

A Paradigm for Drug Discovery Employing Encoded Combinatorial Libraries

Combinatorial Libraries Encoded with Electrophoric Tags

I.~Diastereoselective addition of Grignard reagents to chiral iminium ions: Total synthesis of (S)-(+)-cryptostyline I. II.~Stereospecific total syntheses of decahydroquinoline alkaloids (+,-)-195A and (+,-)-2-epi-195A

Binary encoded small-molecule libraries in drug discovery and optimization

OPERATING LOSS CARRYFORWARDS FOR FIRMS WITH DEFERRED TAX CREDITS

High Throughput Analysis of Combinatorial Libraries Encoded with Electrophoric Molecular Tags

1 - High Throughput Analysis of Combinatorial Libraries Encoded with Electrophoric Molecular Tags

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