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A Potent, Selective Inhibitor of Matrix Metalloproteinase-3 for the Topical Treatment of Chronic Dermal Ulcers

Journal of medicinal chemistry, 2003-07, Vol.46 (16), p.3514-3525

2003

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The design and synthesis of a novel series of indole derived selective ETA antagonists

Bioorganic & medicinal chemistry letters, 2002-01, Vol.12 (2), p.125-128

2002

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Selective Urokinase-Type Plasminogen Activator Inhibitors. 4. 1-(7-Sulfonamidoisoquinolinyl)guanidines

Journal of medicinal chemistry, 2007-05, Vol.50 (10), p.2341-2351

2007

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A novel series of highly selective inhibitors of MMP-3

Bioorganic & medicinal chemistry letters, 2007-12, Vol.17 (24), p.6750-6753

2007

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Absorption, distribution, metabolism, and excretion considerations in selection of orally active indole-containing endothelin antagonist

Drug metabolism and disposition, 2001-11, Vol.29 (11), p.1424

2001

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Selective urokinase-type plasminogen activator (uPA) inhibitors. Part 3: 1-Isoquinolinylguanidines

Bioorganic & medicinal chemistry letters, 2004-06, Vol.14 (12), p.3227-3230

2004

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Thromboxane Modulating Agents. 3. 1H-Imidazol-1-ylalkyl- and 3-Pyridinylalkyl-Substituted 3-[2-[(Arylsulfonyl)amino]ethyl]benzenepropanoic Acid Derivatives as Dual Thromboxane Synthase Inhibitor/Thromboxane Receptor Antagonists

Journal of medicinal chemistry, 1997-10, Vol.40 (21), p.3442-3452

1997

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Selective urokinase-type plasminogen activator (uPA) inhibitors. Part 2: (3-Substituted-5-halo-2-pyridinyl)guanidines

Bioorganic & medicinal chemistry letters, 2002-01, Vol.12 (2), p.185-187

2002

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Selective urokinase-type plasminogen activator (uPA) inhibitors. Part 1: 2-Pyridinylguanidines

Bioorganic & medicinal chemistry letters, 2002-01, Vol.12 (2), p.181-184

2002

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Selectivity of inhibition of matrix metalloproteases MMP-3 and MMP-2 by succinyl hydroxamates and their carboxylic acid analogues is dependent on P3′ group chirality

Bioorganic & medicinal chemistry letters, 2001-02, Vol.11 (4), p.567-570

2001

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Selective thromboxane synthetase inhibitors. 3. 1H-Imidazol-1-yl-substituted benzo[b]furan-, benzo[b]thiophene- and indole-2- and 3-carboxylic acids

Journal of medicinal chemistry, 1986-09, Vol.29 (9), p.1637-1643

1986

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Electrophysiologic Properties of UK-66,914, a Novel Class III Antiarrhythmic Agent

Journal of cardiovascular pharmacology, 1991-03, Vol.17 (3), p.376-385

1991

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Discovery of potent and selective succinyl hydroxamate inhibitors of matrix metalloprotease-3 (Stromelysin-1)

Bioorganic & medicinal chemistry letters, 2001-02, Vol.11 (4), p.571-574

2001

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Selective thromboxane synthetase inhibitors. 1. 1-[(Aryloxy)alkyl]-1H-imidazoles

Journal of medicinal chemistry, 1985-10, Vol.28 (10), p.1427-1432

1985

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Selective thromboxane synthetase inhibitors. 2. 3-(1H-Imidazol-1-ylmethyl)-2-methyl-1H-indole-1-propanoic acid and analogs

Journal of medicinal chemistry, 1986-03, Vol.29 (3), p.342-346

1986

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Novel antifungal 2-aryl-1-(1 H-1,2,4-triazol-1-yl)butan-2-ol derivatives with high activity against Aspergillus fumigatus

Bioorganic & medicinal chemistry letters, 1996-08, Vol.6 (16), p.2031-2036

1996

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The design and synthesis of a novel series of indole derived selective ET A antagonists

Bioorganic & medicinal chemistry letters, 2002-01, Vol.12 (2), p.125-128

2002

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Selective thromboxane synthetase inhibitors. 4. 2-(1H-Imidazol-1-ylmethyl)benzo[b]furan-, -benzo[b]thiophene-, -indole- and -naphthalenecarboxylic acids

Journal of medicinal chemistry, 1986-09, Vol.29 (9), p.1643-1650

1986

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Promotion of carbohydrate oxidation in the heart by some phenylglyoxylic acids

Journal of medicinal chemistry, 1981-04, Vol.24 (4), p.399-404

1981

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Cerebrovasodilatation through selective inhibition of the enzyme carbonic anhydrase. 2. Imidazo[2,1-b]thiadiazole and imidazo[2,1-b]thiazolesulfonamides

Journal of medicinal chemistry, 1980-02, Vol.23 (2), p.117-121

1980

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Cerebrovasodilatation through selective inhibition of the enzyme carbonic anhydrase. 3. 5-(Arylthio)-, 5-(arylsulfinyl)-, and 5-(arylsulfonyl)thiophene-2-sulfonamides

Journal of medicinal chemistry, 1981-08, Vol.24 (8), p.959-964

1981

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The Design and Synthesis of a Novel, Orally Active, Selective ETA Antagonist

Medicinal chemistry research, 2004-01, Vol.13 (3-4), p.149-157

2004

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Thromboxane modulating agents. 4. Design and synthesis of 3-(2-[{(4-chlorophenyl)sulfonyl}amino]ethyl)benzenepropanoic acid derivatives as potent thromboxane receptor antagonists

Bioorganic & medicinal chemistry letters, 1998-08, Vol.8 (16), p.2061-2066

1998

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Thromboxane modulating agents. 1. Design of 1-[(arylsulfonyl)amino] alkylindole derivatives as dual thromboxane synthase inhibitor/thromboxane receptor antagonists

Bioorganic & medicinal chemistry letters, 1995-12, Vol.5 (24), p.3017-3022

1995

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Thromboxane Modulating Agents. 3. 1 H -Imidazol-1-ylalkyl- and 3-Pyridinylalkyl-Substituted 3-[2-[(Arylsulfonyl)amino]ethyl]benzenepropanoic Acid Derivatives as Dual Thromboxane Synthase Inhibitor/Thromboxane Receptor Antagonists

Journal of medicinal chemistry, 1997-10, Vol.40 (21), p.3442-3452

1997

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A Potent, Selective Inhibitor of Matrix Metalloproteinase-3 for the Topical Treatment of Chronic Dermal Ulcers

The design and synthesis of a novel series of indole derived selective ETA antagonists

Selective Urokinase-Type Plasminogen Activator Inhibitors. 4. 1-(7-Sulfonamidoisoquinolinyl)guanidines

A novel series of highly selective inhibitors of MMP-3

Absorption, distribution, metabolism, and excretion considerations in selection of orally active indole-containing endothelin antagonist

Selective urokinase-type plasminogen activator (uPA) inhibitors. Part 3: 1-Isoquinolinylguanidines

Thromboxane Modulating Agents. 3. 1H-Imidazol-1-ylalkyl- and 3-Pyridinylalkyl-Substituted 3-[2-[(Arylsulfonyl)amino]ethyl]benzenepropanoic Acid Derivatives as Dual Thromboxane Synthase Inhibitor/Thromboxane Receptor Antagonists

Selective urokinase-type plasminogen activator (uPA) inhibitors. Part 2: (3-Substituted-5-halo-2-pyridinyl)guanidines

Selective urokinase-type plasminogen activator (uPA) inhibitors. Part 1: 2-Pyridinylguanidines

Selectivity of inhibition of matrix metalloproteases MMP-3 and MMP-2 by succinyl hydroxamates and their carboxylic acid analogues is dependent on P3′ group chirality

Selective thromboxane synthetase inhibitors. 3. 1H-Imidazol-1-yl-substituted benzo[b]furan-, benzo[b]thiophene- and indole-2- and 3-carboxylic acids

Electrophysiologic Properties of UK-66,914, a Novel Class III Antiarrhythmic Agent

Discovery of potent and selective succinyl hydroxamate inhibitors of matrix metalloprotease-3 (Stromelysin-1)

Selective thromboxane synthetase inhibitors. 1. 1-[(Aryloxy)alkyl]-1H-imidazoles

Selective thromboxane synthetase inhibitors. 2. 3-(1H-Imidazol-1-ylmethyl)-2-methyl-1H-indole-1-propanoic acid and analogs

Novel antifungal 2-aryl-1-(1 H-1,2,4-triazol-1-yl)butan-2-ol derivatives with high activity against Aspergillus fumigatus

The design and synthesis of a novel series of indole derived selective ET A antagonists

Selective thromboxane synthetase inhibitors. 4. 2-(1H-Imidazol-1-ylmethyl)benzo[b]furan-, -benzo[b]thiophene-, -indole- and -naphthalenecarboxylic acids

Promotion of carbohydrate oxidation in the heart by some phenylglyoxylic acids

Cerebrovasodilatation through selective inhibition of the enzyme carbonic anhydrase. 2. Imidazo[2,1-b]thiadiazole and imidazo[2,1-b]thiazolesulfonamides

Cerebrovasodilatation through selective inhibition of the enzyme carbonic anhydrase. 3. 5-(Arylthio)-, 5-(arylsulfinyl)-, and 5-(arylsulfonyl)thiophene-2-sulfonamides

The Design and Synthesis of a Novel, Orally Active, Selective ETA Antagonist

Thromboxane modulating agents. 4. Design and synthesis of 3-(2-[{(4-chlorophenyl)sulfonyl}amino]ethyl)benzenepropanoic acid derivatives as potent thromboxane receptor antagonists

Thromboxane modulating agents. 1. Design of 1-[(arylsulfonyl)amino] alkylindole derivatives as dual thromboxane synthase inhibitor/thromboxane receptor antagonists

Thromboxane Modulating Agents. 3. 1 H -Imidazol-1-ylalkyl- and 3-Pyridinylalkyl-Substituted 3-[2-[(Arylsulfonyl)amino]ethyl]benzenepropanoic Acid Derivatives as Dual Thromboxane Synthase Inhibitor/Thromboxane Receptor Antagonists

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