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Safety, efficacy, and dose response of the maturation inhibitor GSK3532795 (formerly known as BMS-955176) plus tenofovir/emtricitabine once daily in treatment-naive HIV-1-infected adults: Week 24 primary analysis from a randomized Phase IIb trial

PloS one, 2018-10, Vol.13 (10), p.e0205368-e0205368

2018

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A socio-spatial analysis of pedestrian falls in Aotearoa New Zealand

Social science & medicine (1982), 2021-11, Vol.288, p.113212, Article 113212

2021

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Mechanistic Studies and Modeling Reveal the Origin of Differential Inhibition of Gag Polymorphic Viruses by HIV-1 Maturation Inhibitors

PLoS pathogens, 2016-11, Vol.12 (11), p.e1005990-e1005990

2016

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Survival from out-of-hospital cardiac arrest: A New Zealand perspective

Heart, lung & circulation, 2015, Vol.24, p.S84-S84

2015

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An Oral Vaccine against NMDAR1 with Efficacy in Experimental Stroke and Epilepsy

Science (American Association for the Advancement of Science), 2000-02, Vol.287 (5457), p.1453-1460

2000

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Generation and Characterization of Torudokimab (LY3375880): A Monoclonal Antibody That Neutralizes Interleukin-33

Journal of inflammation research, 2021-01, Vol.14, p.3823-3835

2021

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Changes to the HIV Long Terminal Repeat and to HIV Integrase Differentially Impact HIV Integrase Assembly, Activity, and the Binding of Strand Transfer Inhibitors

The Journal of biological chemistry, 2007-10, Vol.282 (43), p.31186-31196

2007

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Biochemical Analysis of HIV-1 Integrase Variants Resistant to Strand Transfer Inhibitors

The Journal of biological chemistry, 2008-08, Vol.283 (35), p.23599-23609

2008

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Identification and Characterization of BMS-955176, a Second-Generation HIV-1 Maturation Inhibitor with Improved Potency, Antiviral Spectrum, and Gag Polymorphic Coverage

Antimicrobial agents and chemotherapy, 2016-07, Vol.60 (7), p.3956-3969

2016

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Discovery and Optimization of Novel Pyrazolopyrimidines as Potent and Orally Bioavailable Allosteric HIV‑1 Integrase Inhibitors

Journal of medicinal chemistry, 2020-03, Vol.63 (5), p.2620-2637

2020

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Second Generation Inhibitors of HIV‑1 Maturation

ACS medicinal chemistry letters, 2019-03, Vol.10 (3), p.287-294

2019

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Antiviral Activity, Safety, and Exposure–Response Relationships of GSK3532795, a Second-Generation Human Immunodeficiency Virus Type 1 Maturation Inhibitor, Administered as Monotherapy or in Combination With Atazanavir With or Without Ritonavir in a Phase 2a Randomized, Dose-Ranging, Controlled Trial (AI468002)

Clinical infectious diseases, 2017-08, Vol.65 (3), p.442-452

2017

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Design and exploration of C-3 benzoic acid bioisosteres and alkyl replacements in the context of GSK3532795 (BMS-955176) that exhibit broad spectrum HIV-1 maturation inhibition

Bioorganic & medicinal chemistry letters, 2021-03, Vol.36, p.127823-127823, Article 127823

2021

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Scaffold modifications to the 4-(4,4-dimethylpiperidinyl) 2,6-dimethylpyridinyl class of HIV-1 allosteric integrase inhibitors

Bioorganic & medicinal chemistry, 2022-08, Vol.67, p.116833-116833, Article 116833

2022

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Cultural Safety in Paramedic Practice: Experiences of Māori and Whānau

Heart, lung & circulation, 2023-06, Vol.32, p.S80-S80

2023

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Ventricular Arrhythmia Alerts in Remotely Monitored Implantable Cardioverter Defibrillator Patients: Impact of Manufacturer Differences in Notification Times on Alert Frequency and Patient Management

Heart, lung & circulation, 2023-06, Vol.32, p.S75-S76

2023

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Heterocycle amide isosteres: An approach to overcoming resistance for HIV-1 integrase strand transfer inhibitors

Bioorganic & medicinal chemistry letters, 2020-02, Vol.30 (3), p.126784, Article 126784

2020

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Quantitative comparison of expression with adeno-associated virus (AAV-2) brain-specific gene cassettes

Gene therapy, 2001-09, Vol.8 (17), p.1323-1332

2001

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The discovery and preclinical evaluation of BMS-707035, a potent HIV-1 integrase strand transfer inhibitor

Bioorganic & medicinal chemistry letters, 2018-07, Vol.28 (12), p.2124-2130

2018

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Inhibitors of HIV-1 maturation: Development of structure–activity relationship for C-28 amides based on C-3 benzoic acid-modified triterpenoids

Bioorganic & medicinal chemistry letters, 2016-04, Vol.26 (8), p.1925-1930

2016

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C-3 benzoic acid derivatives of C-3 deoxybetulinic acid and deoxybetulin as HIV-1 maturation inhibitors

Bioorganic & medicinal chemistry, 2016-04, Vol.24 (8), p.1757-1770

2016

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Discovery of BMS-955176, a Second Generation HIV‑1 Maturation Inhibitor with Broad Spectrum Antiviral Activity

ACS medicinal chemistry letters, 2016-06, Vol.7 (6), p.568-572

2016

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Design, Synthesis, and SAR of C-3 Benzoic Acid, C-17 Triterpenoid Derivatives. Identification of the HIV-1 Maturation Inhibitor 4-((1 R,3a S,5a R,5b R,7a R,11a S,11b R,13a R,13b R)-3a-((2-(1,1-Dioxidothiomorpholino)ethyl)amino)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1 H-cyclopenta[ a]chrysen-9-yl)benzoic Acid (GSK3532795, BMS-955176)

Journal of medicinal chemistry, 2018-08, Vol.61 (16), p.7289-7313

2018

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Correction: Normalization strategy for the LC-MS bioanalysis of protein kinetics assays via internal proteolytic analyte utilized as control standard: application in studies of HIV-1 protease cleavage of HIV-1 Gag polyprotein in HIV maturation inhibition research

Analytical methods, 2017-09, Vol.9 (37), p.5557-5557

2017

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Safety, efficacy, and dose response of the maturation inhibitor GSK3532795 (formerly known as BMS-955176) plus tenofovir/emtricitabine once daily in treatment-naive HIV-1-infected adults: Week 24 primary analysis from a randomized Phase IIb trial

A socio-spatial analysis of pedestrian falls in Aotearoa New Zealand

Mechanistic Studies and Modeling Reveal the Origin of Differential Inhibition of Gag Polymorphic Viruses by HIV-1 Maturation Inhibitors

Survival from out-of-hospital cardiac arrest: A New Zealand perspective

An Oral Vaccine against NMDAR1 with Efficacy in Experimental Stroke and Epilepsy

Generation and Characterization of Torudokimab (LY3375880): A Monoclonal Antibody That Neutralizes Interleukin-33

Changes to the HIV Long Terminal Repeat and to HIV Integrase Differentially Impact HIV Integrase Assembly, Activity, and the Binding of Strand Transfer Inhibitors

Biochemical Analysis of HIV-1 Integrase Variants Resistant to Strand Transfer Inhibitors

Identification and Characterization of BMS-955176, a Second-Generation HIV-1 Maturation Inhibitor with Improved Potency, Antiviral Spectrum, and Gag Polymorphic Coverage

Discovery and Optimization of Novel Pyrazolopyrimidines as Potent and Orally Bioavailable Allosteric HIV‑1 Integrase Inhibitors

Second Generation Inhibitors of HIV‑1 Maturation

Design and exploration of C-3 benzoic acid bioisosteres and alkyl replacements in the context of GSK3532795 (BMS-955176) that exhibit broad spectrum HIV-1 maturation inhibition

Scaffold modifications to the 4-(4,4-dimethylpiperidinyl) 2,6-dimethylpyridinyl class of HIV-1 allosteric integrase inhibitors

Cultural Safety in Paramedic Practice: Experiences of Māori and Whānau

Ventricular Arrhythmia Alerts in Remotely Monitored Implantable Cardioverter Defibrillator Patients: Impact of Manufacturer Differences in Notification Times on Alert Frequency and Patient Management

Heterocycle amide isosteres: An approach to overcoming resistance for HIV-1 integrase strand transfer inhibitors

Quantitative comparison of expression with adeno-associated virus (AAV-2) brain-specific gene cassettes

The discovery and preclinical evaluation of BMS-707035, a potent HIV-1 integrase strand transfer inhibitor

Inhibitors of HIV-1 maturation: Development of structure–activity relationship for C-28 amides based on C-3 benzoic acid-modified triterpenoids

C-3 benzoic acid derivatives of C-3 deoxybetulinic acid and deoxybetulin as HIV-1 maturation inhibitors

Discovery of BMS-955176, a Second Generation HIV‑1 Maturation Inhibitor with Broad Spectrum Antiviral Activity

Correction: Normalization strategy for the LC-MS bioanalysis of protein kinetics assays via internal proteolytic analyte utilized as control standard: application in studies of HIV-1 protease cleavage of HIV-1 Gag polyprotein in HIV maturation inhibition research

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