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Emerging agents that target signaling pathways to eradicate colorectal cancer stem cells

Cancer communications (London, England), 2021-12, Vol.41 (12), p.1275-1313

2021

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Challenges and Therapeutic Opportunities of Autophagy in Cancer Therapy

Cancers, 2020-11, Vol.12 (11), p.3461

2020

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Emerging drugs targeting cellular redox homeostasis to eliminate acute myeloid leukemia stem cells

Redox biology, 2023-06, Vol.62, p.102692-102692, Article 102692

2023

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Ruthenium complex containing 1,3-thiazolidine-2-thione inhibits hepatic cancer stem cells by suppressing Akt/mTOR signalling and leading to apoptotic and autophagic cell death

Biomedicine & pharmacotherapy, 2024-08, Vol.177, p.117059, Article 117059

2024

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New ruthenium-xanthoxylin complex eliminates colorectal cancer stem cells by targeting the heat shock protein 90 chaperone

Cell death & disease, 2023-12, Vol.14 (12), p.832-832, Article 832

2023

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In vitro and in vivo growth inhibition of human acute promyelocytic leukemia HL-60 cells by Guatteria megalophylla Diels (Annonaceae) leaf essential oil

Biomedicine & pharmacotherapy, 2020-02, Vol.122, p.109713-109713, Article 109713

2020

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Duguetia pycnastera Sandwith (Annonaceae) Leaf Essential Oil Inhibits HepG2 Cell Growth In Vitro and In Vivo

Molecules (Basel, Switzerland), 2022-09, Vol.27 (17), p.5664

2022

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Antitumor Effect of Guatteria olivacea R. E. Fr. (Annonaceae) Leaf Essential Oil in Liver Cancer

Molecules (Basel, Switzerland), 2022-07, Vol.27 (14), p.4407

2022

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Tingenone and 22-hydroxytingenone target oxidative stress through downregulation of thioredoxin, leading to DNA double-strand break and JNK/p38-mediated apoptosis in acute myeloid leukemia HL-60 cells

Biomedicine & pharmacotherapy, 2021-10, Vol.142, p.112034-112034, Article 112034

2021

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Combination Therapy of Curcumin and Disulfiram Synergistically Inhibits the Growth of B16-F10 Melanoma Cells by Inducing Oxidative Stress

Biomolecules (Basel, Switzerland), 2022-10, Vol.12 (11), p.1600

2022

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Cyperus articulatus L. (Cyperaceae) Rhizome Essential Oil Causes Cell Cycle Arrest in the G2/M Phase and Cell Death in HepG2 Cells and Inhibits the Development of Tumors in a Xenograft Model

Molecules (Basel, Switzerland), 2020-06, Vol.25 (11), p.2687

2020

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Ruthenium Complexes With Piplartine Cause Apoptosis Through MAPK Signaling by a p53-Dependent Pathway in Human Colon Carcinoma Cells and Inhibit Tumor Development in a Xenograft Model

Frontiers in oncology, 2019-07, Vol.9, p.582-582

2019

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Bithionol eliminates acute myeloid leukaemia stem-like cells by suppressing NF-κB signalling and inducing oxidative stress, leading to apoptosis and ferroptosis

Cell death discovery, 2024-08, Vol.10 (1), p.390-14, Article 390

2024

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Essential oil from leaves of Conobea scoparioides (Cham. & Schltdl.) Benth. (Plantaginaceae) causes cell death in HepG2 cells and inhibits tumor development in a xenograft model

Biomedicine & pharmacotherapy, 2020-09, Vol.129, p.110402-110402, Article 110402

2020

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Ruthenium Complexes Containing Heterocyclic Thioamidates Trigger Caspase-Mediated Apoptosis Through MAPK Signaling in Human Hepatocellular Carcinoma Cells

Frontiers in oncology, 2019-07, Vol.9, p.562-562

2019

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A novel ruthenium complex with 5-fluorouracil suppresses colorectal cancer stem cells by inhibiting Akt/mTOR signaling

Cell death discovery, 2023-12, Vol.9 (1), p.460-460, Article 460

2023

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Emetine induces oxidative stress, cell differentiation and NF-κB inhibition, suppressing AML stem/progenitor cells

Cell death discovery, 2024-04, Vol.10 (1), p.201-201, Article 201

2024

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Piplartine eliminates CD34 + AML stem/progenitor cells by inducing oxidative stress and suppressing NF-κB signalling

Cell death discovery, 2024-03, Vol.10 (1), p.147-147, Article 147

2024

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Ru(II)-based complexes containing 2-thiouracil derivatives suppress liver cancer stem cells by targeting NF-κB and Akt/mTOR signaling

Cell death discovery, 2024-06, Vol.10 (1), p.270-270

2024

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Cell signaling pathways as molecular targets to eliminate AML stem cells

Critical reviews in oncology/hematology, 2021-04, Vol.160, p.103277-103277, Article 103277

2021

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In vitro and in vivo anti-leukemia activity of the stem bark of Salacia impressifolia (Miers) A. C. Smith (Celastraceae)

Journal of ethnopharmacology, 2019-03, Vol.231, p.516-524

2019

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Ru(II)-thymine complex causes DNA damage and apoptotic cell death in human colon carcinoma HCT116 cells mediated by JNK/p38/ERK1/2 via a p53-independent signaling

Scientific reports, 2019-07, Vol.9 (1), p.11094-11, Article 11094

2019

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Ruthenium(II) complexes with 6-methyl-2-thiouracil selectively reduce cell proliferation, cause DNA double-strand break and trigger caspase-mediated apoptosis through JNK/p38 pathways in human acute promyelocytic leukemia cells

Scientific reports, 2019-08, Vol.9 (1), p.11483-17, Article 11483

2019

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A new synthetic antitumor naphthoquinone induces ROS-mediated apoptosis with activation of the JNK and p38 signaling pathways

Chemico-biological interactions, 2021-07, Vol.343, p.109444, Article 109444

2021

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A novel ruthenium complex with xanthoxylin induces S-phase arrest and causes ERK1/2-mediated apoptosis in HepG2 cells through a p53-independent pathway

Cell death & disease, 2018-01, Vol.9 (2), p.79-24, Article 79

2018

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Emerging agents that target signaling pathways to eradicate colorectal cancer stem cells

Challenges and Therapeutic Opportunities of Autophagy in Cancer Therapy

Emerging drugs targeting cellular redox homeostasis to eliminate acute myeloid leukemia stem cells

Ruthenium complex containing 1,3-thiazolidine-2-thione inhibits hepatic cancer stem cells by suppressing Akt/mTOR signalling and leading to apoptotic and autophagic cell death

New ruthenium-xanthoxylin complex eliminates colorectal cancer stem cells by targeting the heat shock protein 90 chaperone

In vitro and in vivo growth inhibition of human acute promyelocytic leukemia HL-60 cells by Guatteria megalophylla Diels (Annonaceae) leaf essential oil

Duguetia pycnastera Sandwith (Annonaceae) Leaf Essential Oil Inhibits HepG2 Cell Growth In Vitro and In Vivo

Antitumor Effect of Guatteria olivacea R. E. Fr. (Annonaceae) Leaf Essential Oil in Liver Cancer

Tingenone and 22-hydroxytingenone target oxidative stress through downregulation of thioredoxin, leading to DNA double-strand break and JNK/p38-mediated apoptosis in acute myeloid leukemia HL-60 cells

Combination Therapy of Curcumin and Disulfiram Synergistically Inhibits the Growth of B16-F10 Melanoma Cells by Inducing Oxidative Stress

Cyperus articulatus L. (Cyperaceae) Rhizome Essential Oil Causes Cell Cycle Arrest in the G2/M Phase and Cell Death in HepG2 Cells and Inhibits the Development of Tumors in a Xenograft Model

Ruthenium Complexes With Piplartine Cause Apoptosis Through MAPK Signaling by a p53-Dependent Pathway in Human Colon Carcinoma Cells and Inhibit Tumor Development in a Xenograft Model

Bithionol eliminates acute myeloid leukaemia stem-like cells by suppressing NF-κB signalling and inducing oxidative stress, leading to apoptosis and ferroptosis

Essential oil from leaves of Conobea scoparioides (Cham. & Schltdl.) Benth. (Plantaginaceae) causes cell death in HepG2 cells and inhibits tumor development in a xenograft model

Ruthenium Complexes Containing Heterocyclic Thioamidates Trigger Caspase-Mediated Apoptosis Through MAPK Signaling in Human Hepatocellular Carcinoma Cells

A novel ruthenium complex with 5-fluorouracil suppresses colorectal cancer stem cells by inhibiting Akt/mTOR signaling

Emetine induces oxidative stress, cell differentiation and NF-κB inhibition, suppressing AML stem/progenitor cells

Piplartine eliminates CD34 + AML stem/progenitor cells by inducing oxidative stress and suppressing NF-κB signalling

Ru(II)-based complexes containing 2-thiouracil derivatives suppress liver cancer stem cells by targeting NF-κB and Akt/mTOR signaling

Cell signaling pathways as molecular targets to eliminate AML stem cells

In vitro and in vivo anti-leukemia activity of the stem bark of Salacia impressifolia (Miers) A. C. Smith (Celastraceae)

Ru(II)-thymine complex causes DNA damage and apoptotic cell death in human colon carcinoma HCT116 cells mediated by JNK/p38/ERK1/2 via a p53-independent signaling

Ruthenium(II) complexes with 6-methyl-2-thiouracil selectively reduce cell proliferation, cause DNA double-strand break and trigger caspase-mediated apoptosis through JNK/p38 pathways in human acute promyelocytic leukemia cells

A new synthetic antitumor naphthoquinone induces ROS-mediated apoptosis with activation of the JNK and p38 signaling pathways

A novel ruthenium complex with xanthoxylin induces S-phase arrest and causes ERK1/2-mediated apoptosis in HepG2 cells through a p53-independent pathway

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