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Linear and Nonlinear Modes and Data Signatures in Dynamic Systems Biology Models

Applied sciences, 2023-09, Vol.13 (17), p.9772

DiStefano, Joseph

2023

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On finding and using identifiable parameter combinations in nonlinear dynamic systems biology models and COMBOS: a novel web implementation

PloS one, 2014-10, Vol.9 (10), p.e110261-e110261

2014

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Predicting Optimal Combination LT4 + LT3 Therapy for Hypothyroidism Based on Residual Thyroid Function

Frontiers in endocrinology (Lausanne), 2019-11, Vol.10, p.746-746

2019

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Editorial: Mechanistic, machine learning and hybrid models of the "other" endocrine regulatory systems in health & disease

Frontiers in endocrinology (Lausanne), 2023-01, Vol.14, p.1104746-1104746

2023

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Establishing laboratory-specific reference intervals for TSH and fT4 by use of the indirect Hoffman method

PloS one, 2022-01, Vol.17 (1), p.e0261715

2022

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An algorithm for finding globally identifiable parameter combinations of nonlinear ODE models using Gröbner Bases

Mathematical biosciences, 2009-12, Vol.222 (2), p.61-72

2009

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Optimized Replacement T4 and T4+T3 Dosing in Male and Female Hypothyroid Patients With Different BMIs Using a Personalized Mechanistic Model of Thyroid Hormone Regulation Dynamics

Frontiers in endocrinology (Lausanne), 2022-07, Vol.13, p.888429

2022

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Alternative to Ritt’s pseudodivision for finding the input-output equations of multi-output models

Mathematical biosciences, 2012-09, Vol.239 (1), p.117-123

2012

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Extensions, validation, and clinical applications of a feedback control system simulator of the hypothalamo-pituitary-thyroid axis

Thyroid (New York, N.Y.), 2008-10, Vol.18 (10), p.1071-1085

2008

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A long-term mechanistic computational model of physiological factors driving the onset of type 2 diabetes in an individual

PloS one, 2018-02, Vol.13 (2), p.e0192472-e0192472

2018

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A predictive model of therapeutic monoclonal antibody dynamics and regulation by the neonatal Fc receptor (FcRn)

Annals of biomedical engineering, 2005-11, Vol.33 (11), p.1640-1652

2005

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Parameter estimation and mathematical modeling for the quantitative description of therapy failure due to drug resistance in gastrointestinal stromal tumor metastasis to the liver

PloS one, 2019-05, Vol.14 (5), p.e0217332-e0217332

2019

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Advances in applied homeostatic modelling of the relationship between thyrotropin and free thyroxine

PloS one, 2017-11, Vol.12 (11), p.e0187232-e0187232

2017

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Predicting chemical impacts on vertebrate endocrine systems

Environmental toxicology and chemistry, 2011-01, Vol.30 (1), p.39-51

2011

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A two-tiered physiologically based model for dually labeled single-chain Fv-Fc antibody fragments

Molecular cancer therapeutics, 2006-06, Vol.5 (6), p.1550-1558

2006

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DISTING: A Web Application for Fast Algorithmic Computation of Alternative Indistinguishable Linear Compartmental Models

Computer methods and programs in biomedicine, 2017-05, Vol.143, p.129-135

2017

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TSH regulation dynamics in central and extreme primary hypothyroidism

Thyroid (New York, N.Y.), 2010-11, Vol.20 (11), p.1215-1228

2010

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Corrigendum to “DISTING: A web application for fast algorithmic computation of alternative indistinguishable linear compartmental models” [Computer Methods and Programs in Biomedicine 143 (2017) 129–135]

Computer methods and programs in biomedicine, 2017-07, Vol.146, p.25-25

2017

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Finding identifiable parameter combinations in nonlinear ODE models and the rational reparameterization of their input–output equations

Mathematical biosciences, 2011-09, Vol.233 (1), p.19-31

2011

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COMBOS2: an algorithm to the input-output equations of dynamic biosystems via Gaussian elimination

Journal of Taibah University for Science, 2020-01, Vol.14 (1), p.896-907

2020

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Using Physiological Information to Classify Task Difficulty in Human-Swarm Interaction

2021 IEEE International Conference on Systems, Man, and Cybernetics (SMC), 2021, p.1198-1203

2021

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Parameter Identification of an Ultrafiltration Model for Organics Removal in a Full-Scale Wastewater Reclamation Plant with Sparse and Incomplete Monitoring Data

PloS one, 2016-08, Vol.11 (8), p.e0161300-e0161300

2016

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The thyroid cancer policy model: A mathematical simulation model of papillary thyroid carcinoma in The U.S. population

PloS one, 2017-05, Vol.12 (5), p.e0177068-e0177068

2017

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Using Physiological Measurements to Analyze the Tactical Decisions in Human Swarm Teams

2020 IEEE International Conference on Systems, Man, and Cybernetics (SMC), 2020, p.256-261

2020

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Simulation of post-thyroidectomy treatment alternatives for triiodothyronine or thyroxine replacement in pediatric thyroid cancer patients

Thyroid (New York, N.Y.), 2012-06, Vol.22 (6), p.595-603

2012

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Linear and Nonlinear Modes and Data Signatures in Dynamic Systems Biology Models

On finding and using identifiable parameter combinations in nonlinear dynamic systems biology models and COMBOS: a novel web implementation

Predicting Optimal Combination LT4 + LT3 Therapy for Hypothyroidism Based on Residual Thyroid Function

Editorial: Mechanistic, machine learning and hybrid models of the "other" endocrine regulatory systems in health & disease

Establishing laboratory-specific reference intervals for TSH and fT4 by use of the indirect Hoffman method

An algorithm for finding globally identifiable parameter combinations of nonlinear ODE models using Gröbner Bases

Optimized Replacement T4 and T4+T3 Dosing in Male and Female Hypothyroid Patients With Different BMIs Using a Personalized Mechanistic Model of Thyroid Hormone Regulation Dynamics

Alternative to Ritt’s pseudodivision for finding the input-output equations of multi-output models

Extensions, validation, and clinical applications of a feedback control system simulator of the hypothalamo-pituitary-thyroid axis

A long-term mechanistic computational model of physiological factors driving the onset of type 2 diabetes in an individual

A predictive model of therapeutic monoclonal antibody dynamics and regulation by the neonatal Fc receptor (FcRn)

Parameter estimation and mathematical modeling for the quantitative description of therapy failure due to drug resistance in gastrointestinal stromal tumor metastasis to the liver

Advances in applied homeostatic modelling of the relationship between thyrotropin and free thyroxine

Predicting chemical impacts on vertebrate endocrine systems

A two-tiered physiologically based model for dually labeled single-chain Fv-Fc antibody fragments

DISTING: A Web Application for Fast Algorithmic Computation of Alternative Indistinguishable Linear Compartmental Models

TSH regulation dynamics in central and extreme primary hypothyroidism

Corrigendum to “DISTING: A web application for fast algorithmic computation of alternative indistinguishable linear compartmental models” [Computer Methods and Programs in Biomedicine 143 (2017) 129–135]

Finding identifiable parameter combinations in nonlinear ODE models and the rational reparameterization of their input–output equations

COMBOS2: an algorithm to the input-output equations of dynamic biosystems via Gaussian elimination

Using Physiological Information to Classify Task Difficulty in Human-Swarm Interaction

Parameter Identification of an Ultrafiltration Model for Organics Removal in a Full-Scale Wastewater Reclamation Plant with Sparse and Incomplete Monitoring Data

The thyroid cancer policy model: A mathematical simulation model of papillary thyroid carcinoma in The U.S. population

Using Physiological Measurements to Analyze the Tactical Decisions in Human Swarm Teams

Simulation of post-thyroidectomy treatment alternatives for triiodothyronine or thyroxine replacement in pediatric thyroid cancer patients

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