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Differential Fc-Receptor Engagement Drives an Anti-tumor Vaccinal Effect

Cell, 2015-05, Vol.161 (5), p.1035-1045

2015

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Modulating IgG effector function by Fc glycan engineering

Proceedings of the National Academy of Sciences - PNAS, 2017-03, Vol.114 (13), p.3485-3490

2017

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B10 cells and regulatory B cells balance immune responses during inflammation, autoimmunity, and cancer

Annals of the New York Academy of Sciences, 2010-01, Vol.1183 (1), p.38-57

2010

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Mouse model recapitulating human Fcγ receptor structural and functional diversity

Proceedings of the National Academy of Sciences - PNAS, 2012-04, Vol.109 (16), p.6181-6186

2012

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Site-selective chemoenzymatic glycoengineering of Fab and Fc glycans of a therapeutic antibody

Proceedings of the National Academy of Sciences - PNAS, 2018-11, Vol.115 (47), p.12023-12027

2018

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Fc-Receptor Interactions Regulate Both Cytotoxic and Immunomodulatory Therapeutic Antibody Effector Functions

Cancer immunology research, 2015-07, Vol.3 (7), p.704-713

2015

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Regulatory B cell (B10 Cell) expansion during Listeria infection governs innate and cellular immune responses in mice

The Journal of immunology (1950), 2013-02, Vol.190 (3), p.1158-1168

2013

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Maintenance of Long-Lived Plasma Cells and Serological Memory Despite Mature and Memory B Cell Depletion during CD20 Immunotherapy in Mice

The Journal of immunology (1950), 2008-01, Vol.180 (1), p.361-371

2008

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Broadly neutralizing hemagglutinin stalk–specific antibodies require FcγR interactions for protection against influenza virus in vivo

Nature medicine, 2014-02, Vol.20 (2), p.143-151

2014

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Broadly neutralizing anti-influenza antibodies require Fc receptor engagement for in vivo protection

The Journal of clinical investigation, 2016-02, Vol.126 (2), p.605-610

2016

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The role of Fc-FcγR interactions in IgG-mediated microbial neutralization

The Journal of experimental medicine, 2015-08, Vol.212 (9), p.1361-1369

2015

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Rituximab Infusion Promotes Rapid Complement Depletion and Acute CD20 Loss in Chronic Lymphocytic Leukemia

The Journal of immunology (1950), 2004-03, Vol.172 (5), p.3280-3288

2004

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B Cells Are Required for Optimal CD4+ and CD8+ T Cell Tumor Immunity: Therapeutic B Cell Depletion Enhances B16 Melanoma Growth in Mice

The Journal of immunology (1950), 2010-04, Vol.184 (7), p.4006-4016

2010

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Type I and type II Fc receptors regulate innate and adaptive immunity

Nature immunology, 2014-08, Vol.15 (8), p.707-716

2014

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Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions

Nature (London), 2012-11, Vol.491 (7423), p.264-268

2012

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B-lymphocyte effector functions in health and disease

Immunologic research, 2011-04, Vol.49 (1-3), p.281-292

2011

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IL-15 enhanced antibody-dependent cellular cytotoxicity mediated by NK cells and macrophages

Proceedings of the National Academy of Sciences - PNAS, 2018-11, Vol.115 (46), p.E10915-E10924

2018

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Differential requirements for FcγR engagement by protective antibodies against Ebola virus

Proceedings of the National Academy of Sciences - PNAS, 2019-10, Vol.116 (40), p.20054-20062

2019

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Characterization of a rare IL-10–competent B-cell subset in humans that parallels mouse regulatory B10 cells

Blood, 2011-01, Vol.117 (2), p.530-541

2011

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LTβR Agonism Promotes Anti-Tumor Immune Responses via Modulation of the Tumor Microenvironment

Cancer research (Chicago, Ill.), 2024-08

2024

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Regulatory B10 cells differentiate into antibody-secreting cells after transient IL-10 production in vivo

The Journal of immunology (1950), 2012-02, Vol.188 (3), p.1036-1048

2012

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Generation of T-cell-redirecting bispecific antibodies with differentiated profiles of cytokine release and biodistribution by CD3 affinity tuning

Scientific reports, 2021-07, Vol.11 (1), p.14397-17, Article 14397

2021

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B lymphocytes differentially influence acute and chronic allograft rejection in mice

The Journal of immunology (1950), 2011-02, Vol.186 (4), p.2643-2654

2011

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A BCMAxCD3 bispecific T cell–engaging antibody demonstrates robust antitumor efficacy similar to that of anti-BCMA CAR T cells

Blood advances, 2021-03, Vol.5 (5), p.1291-1304

2021

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Engineering Aglycosylated IgG Variants with Wild-Type or Improved Binding Affinity to Human Fc Gamma RIIA and Fc Gamma RIIIAs

Journal of molecular biology, 2017-08, Vol.429 (16), p.2528-2541

2017

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Differential Fc-Receptor Engagement Drives an Anti-tumor Vaccinal Effect

Modulating IgG effector function by Fc glycan engineering

B10 cells and regulatory B cells balance immune responses during inflammation, autoimmunity, and cancer

Mouse model recapitulating human Fcγ receptor structural and functional diversity

Site-selective chemoenzymatic glycoengineering of Fab and Fc glycans of a therapeutic antibody

Fc-Receptor Interactions Regulate Both Cytotoxic and Immunomodulatory Therapeutic Antibody Effector Functions

Regulatory B cell (B10 Cell) expansion during Listeria infection governs innate and cellular immune responses in mice

Maintenance of Long-Lived Plasma Cells and Serological Memory Despite Mature and Memory B Cell Depletion during CD20 Immunotherapy in Mice

Broadly neutralizing hemagglutinin stalk–specific antibodies require FcγR interactions for protection against influenza virus in vivo

Broadly neutralizing anti-influenza antibodies require Fc receptor engagement for in vivo protection

The role of Fc-FcγR interactions in IgG-mediated microbial neutralization

Rituximab Infusion Promotes Rapid Complement Depletion and Acute CD20 Loss in Chronic Lymphocytic Leukemia

B Cells Are Required for Optimal CD4+ and CD8+ T Cell Tumor Immunity: Therapeutic B Cell Depletion Enhances B16 Melanoma Growth in Mice

Type I and type II Fc receptors regulate innate and adaptive immunity

Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions

B-lymphocyte effector functions in health and disease

IL-15 enhanced antibody-dependent cellular cytotoxicity mediated by NK cells and macrophages

Differential requirements for FcγR engagement by protective antibodies against Ebola virus

Characterization of a rare IL-10–competent B-cell subset in humans that parallels mouse regulatory B10 cells

LTβR Agonism Promotes Anti-Tumor Immune Responses via Modulation of the Tumor Microenvironment

Regulatory B10 cells differentiate into antibody-secreting cells after transient IL-10 production in vivo

Generation of T-cell-redirecting bispecific antibodies with differentiated profiles of cytokine release and biodistribution by CD3 affinity tuning

B lymphocytes differentially influence acute and chronic allograft rejection in mice

A BCMAxCD3 bispecific T cell–engaging antibody demonstrates robust antitumor efficacy similar to that of anti-BCMA CAR T cells

Engineering Aglycosylated IgG Variants with Wild-Type or Improved Binding Affinity to Human Fc Gamma RIIA and Fc Gamma RIIIAs

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