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HDACs, histone deacetylation and gene transcription: from molecular biology to cancer therapeutics

Cell research, 2007-03, Vol.17 (3), p.195-211

2007

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The crystal structure of the quorum sensing protein TraR bound to its autoinducer and target DNA

The EMBO journal, 2002-09, Vol.21 (17), p.4393-4401

2002

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A third generation vaccine for human visceral leishmaniasis and post kala azar dermal leishmaniasis: First-in-human trial of ChAd63-KH

PLoS neglected tropical diseases, 2017-05, Vol.11 (5), p.e0005527-e0005527

2017

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Substrate binding to histone deacetylases as shown by the crystal structure of the HDAC8-substrate complex

EMBO reports, 2007-09, Vol.8 (9), p.879-884

2007

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Chronic hepatitis C viral infection subverts vaccine‐induced T‐cell immunity in humans

Hepatology (Baltimore, Md.), 2016-05, Vol.63 (5), p.1455-1470

2016

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Crystal Structure of a Eukaryotic Zinc-Dependent Histone Deacetylase, Human HDAC8, Complexed with a Hydroxamic Acid Inhibitor

Proceedings of the National Academy of Sciences - PNAS, 2004-10, Vol.101 (42), p.15064-15069

2004

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Optimization of Thienopyrrole‐Based Finger‐Loop Inhibitors of the Hepatitis C Virus NS5B Polymerase

ChemMedChem, 2009-10, Vol.4 (10), p.1695-1713

2009

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The three-dimensional structure of caspase-8: an initiator enzyme in apoptosis

Structure (London), 1999-09, Vol.7 (9), p.1125-1133

1999

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PCSK9-binding antibody that structurally mimics the EGF(A) domain of LDL-receptor reduces LDL cholesterol in vivo

Journal of lipid research, 2011, Vol.52 (1), p.78-86

2011

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Human vaccination against RH5 induces neutralizing antimalarial antibodies that inhibit RH5 invasion complex interactions

JCI insight, 2017-11, Vol.2 (21)

2017

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Nucleic Acid Binding of the RTN1-C C-Terminal Region: Toward the Functional Role of a Reticulon Protein

Biochemistry (Easton), 2009-01, Vol.48 (2), p.242-253

2009

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Adenovirus DNA Polymerase Loses Fidelity on a Stretch of Eleven Homocytidines during Pre-GMP Vaccine Preparation

Vaccines (Basel), 2022-06, Vol.10 (6), p.960

2022

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Interdomain Communication in Hepatitis C Virus Polymerase Abolished by Small Molecule Inhibitors Bound to a Novel Allosteric Site

The Journal of biological chemistry, 2005-08, Vol.280 (33), p.29765-29770

2005

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Studies on the Mode of Ku Interaction with DNA

The Journal of biological chemistry, 2002-03, Vol.277 (12), p.9741-9748

2002

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Cyclic nucleotide phosphodiesterase activity in stem cells of human periodontal ligament (PDL-MSCs) before and after osteogenic induction

Oral surgery, oral medicine, oral pathology and oral radiology, 2013-11, Vol.116 (5), p.e317-e323

2013

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Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young and old adults (COV002): a single-blind, randomised, controlled, phase 2/3 trial

The Lancet (British edition), 2020-12, Vol.396 (10267), p.1979-1993

2020

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Crystal Structure of the Quorum-sensing Protein TraM and Its Interaction with the Transcriptional Regulator TraR

The Journal of biological chemistry, 2004-06, Vol.279 (23), p.24291-24296

2004

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Structure of Recombinant Human CPP32 in Complex with the Tetrapeptide Acetyl-Asp-Val-Ala-Asp Fluoromethyl Ketone

The Journal of biological chemistry, 1997-03, Vol.272 (10), p.6539-6547

1997

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The Design and Enzyme-Bound Crystal Structure of Indoline Based Peptidomimetic Inhibitors of Hepatitis C Virus NS3 Protease

Journal of medicinal chemistry, 2004-12, Vol.47 (26), p.6443-6446

2004

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A Monovalent Chimpanzee Adenovirus Ebola Vaccine Boosted with MVA

The New England journal of medicine, 2016-04, Vol.374 (17), p.1635-1646

2016

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Chimpanzee adenovirus- and MVA-vectored respiratory syncytial virus vaccine is safe and immunogenic in adults

Science translational medicine, 2015-08, Vol.7 (300), p.300ra126

2015

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A PCSK9-binding antibody that structurally mimics the EGF(A) domain of LDL-receptor reduces LDL cholesterol in vivo1[S]

Journal of lipid research, 2011-01, Vol.52 (1), p.78-86

2011

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A Proprotein Convertase Subtilisin-like/Kexin Type 9 (PCSK9) C-terminal Domain Antibody Antigen-binding Fragment Inhibits PCSK9 Internalization and Restores Low Density Lipoprotein Uptake

The Journal of biological chemistry, 2010-04, Vol.285 (17), p.12882-12891

2010

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HDACs, histone deacetylation and gene transcription: from molecular biology to cancer therapeutics

The crystal structure of the quorum sensing protein TraR bound to its autoinducer and target DNA

A third generation vaccine for human visceral leishmaniasis and post kala azar dermal leishmaniasis: First-in-human trial of ChAd63-KH

Substrate binding to histone deacetylases as shown by the crystal structure of the HDAC8-substrate complex

Chronic hepatitis C viral infection subverts vaccine‐induced T‐cell immunity in humans

Crystal Structure of a Eukaryotic Zinc-Dependent Histone Deacetylase, Human HDAC8, Complexed with a Hydroxamic Acid Inhibitor

Optimization of Thienopyrrole‐Based Finger‐Loop Inhibitors of the Hepatitis C Virus NS5B Polymerase

The three-dimensional structure of caspase-8: an initiator enzyme in apoptosis

PCSK9-binding antibody that structurally mimics the EGF(A) domain of LDL-receptor reduces LDL cholesterol in vivo

Human vaccination against RH5 induces neutralizing antimalarial antibodies that inhibit RH5 invasion complex interactions

Nucleic Acid Binding of the RTN1-C C-Terminal Region: Toward the Functional Role of a Reticulon Protein

Adenovirus DNA Polymerase Loses Fidelity on a Stretch of Eleven Homocytidines during Pre-GMP Vaccine Preparation

Interdomain Communication in Hepatitis C Virus Polymerase Abolished by Small Molecule Inhibitors Bound to a Novel Allosteric Site

Studies on the Mode of Ku Interaction with DNA

Cyclic nucleotide phosphodiesterase activity in stem cells of human periodontal ligament (PDL-MSCs) before and after osteogenic induction

Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young and old adults (COV002): a single-blind, randomised, controlled, phase 2/3 trial

Crystal Structure of the Quorum-sensing Protein TraM and Its Interaction with the Transcriptional Regulator TraR

Structure of Recombinant Human CPP32 in Complex with the Tetrapeptide Acetyl-Asp-Val-Ala-Asp Fluoromethyl Ketone

The Design and Enzyme-Bound Crystal Structure of Indoline Based Peptidomimetic Inhibitors of Hepatitis C Virus NS3 Protease

A Monovalent Chimpanzee Adenovirus Ebola Vaccine Boosted with MVA

Chimpanzee adenovirus- and MVA-vectored respiratory syncytial virus vaccine is safe and immunogenic in adults

A PCSK9-binding antibody that structurally mimics the EGF(A) domain of LDL-receptor reduces LDL cholesterol in vivo1[S]

Discovery of (7 R )-14-Cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6 H -indolo[1,2- e ][1,5]benzoxazocine-11-carboxylic Acid (MK-3281), a Potent and Orally Bioavailable Finger-Loop Inhibitor of the Hepatitis C Virus NS5B Polymerase

Discovery of (7R)-14-Cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylic Acid (MK-3281), a Potent and Orally Bioavailable Finger-Loop Inhibitor of the Hepatitis C Virus NS5B Polymerase

A Proprotein Convertase Subtilisin-like/Kexin Type 9 (PCSK9) C-terminal Domain Antibody Antigen-binding Fragment Inhibits PCSK9 Internalization and Restores Low Density Lipoprotein Uptake

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