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Design of an in vitro biocatalytic cascade for the manufacture of islatravir

Science (American Association for the Advancement of Science), 2019-12, Vol.366 (6470), p.1255-1259

2019

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Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture

Science (American Association for the Advancement of Science), 2010-07, Vol.329 (5989), p.305-309

2010

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Biocatalysis in drug discovery and development

Current opinion in chemical biology, 2020-04, Vol.55, p.151-160

2020

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Advances in the Enzymatic Reduction of Ketones

Accounts of chemical research, 2007-12, Vol.40 (12), p.1412-1419

2007

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Hemoprotein‐Catalyzed Cyclopropanation En Route to the Chiral Cyclopropanol Fragment of Grazoprevir

Chembiochem : a European journal of chemical biology, 2019-05, Vol.20 (9), p.1129-1132

2019

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Extending the application of biocatalysis to meet the challenges of drug development

Nature reviews. Chemistry, 2018-12, Vol.2 (12), p.409-421

2018

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A kinase-cGAS cascade to synthesize a therapeutic STING activator

Nature (London), 2022-03, Vol.603 (7901), p.439-444

2022

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Diastereoselective Reductive Amination of Aryl Trifluoromethyl Ketones and α-Amino Esters

Angewandte Chemie International Edition, 2007-01, Vol.46 (11), p.1839-1842

2007

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Efficient Synthesis of NK1 Receptor Antagonist Aprepitant Using a Crystallization-Induced Diastereoselective Transformation

Journal of the American Chemical Society, 2003-02, Vol.125 (8), p.2129-2135

2003

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Palladium-Catalyzed Regioselective Arylation of Imidazo[1,2-b][1,2,4]triazine: Synthesis of an α2/ 3-Selective GABA Agonist

Journal of organic chemistry, 2005-07, Vol.70 (15), p.5938-5945

2005

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A chemoenzymatic strategy for site-selective functionalization of native peptides and proteins

Science (American Association for the Advancement of Science), 2022-06, Vol.376 (6599), p.1321-1327

2022

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Facile Synthesis of 2-Bromo-3-fluorobenzonitrile: An Application and Study of the Halodeboronation of Aryl Boronic Acids

Journal of organic chemistry, 2004-01, Vol.69 (2), p.566-569

2004

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Synthesis of a Tertiary Carbinamide via a Novel Rh-Catalyzed Asymmetric Hydrogenation

Journal of organic chemistry, 2008-02, Vol.73 (4), p.1639-1642

2008

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Convergent Kilogram-Scale Synthesis of Dual Orexin Receptor Antagonist

Organic process research & development, 2013-01, Vol.17 (1), p.61-68

2013

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Asymmetric Synthesis of cis-2,5-Disubstituted Pyrrolidine, the Core Scaffold of β3‑AR Agonists

Organic letters, 2013-03, Vol.15 (6), p.1342-1345

2013

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Synthesis of Vaniprevir (MK-7009): Lactamization To Prepare a 22-Membered Macrocycle

Journal of organic chemistry, 2011-10, Vol.76 (19), p.7804-7815

2011

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Chemo- and Enantioselective Routes to Chiral Fluorinated Hydroxyketones Using Ketoreductases

Organic letters, 2007-11, Vol.9 (24), p.4951-4954

2007

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Practical Synthesis of A Macrocyclic HCV Protease Inhibitor: A High-Yielding Macrolactam Formation

Organic process research & development, 2014-03, Vol.18 (3), p.423-430

2014

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Production of ( S ) - γ -fluoroleucine ethyl ester by enzyme mediated dynamic kinetic resolution: Comparison of batch and fed batch stirred tank processes to a packed bed column reactor

Chemical engineering science, 2008, Vol.63 (1), p.122-130

2008

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A generic platform for the immobilisation of engineered biocatalysts

Tetrahedron, 2019-01, Vol.75 (3), p.327-334

2019

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An Asymmetric Synthesis of 3-Aryl-1,4-oxazin-2-ones: Synthesis of a Key Intermediate of an NK1 Receptor Antagonist

Heterocycles, 2002-11, Vol.58 (1), p.119

2002

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Scalable, efficient process for the synthesis of ( R)-3,5-bistrifluoromethylphenyl ethanol via catalytic asymmetric transfer hydrogenation and isolation as a DABCO inclusion complex

Tetrahedron: asymmetry, 2003-11, Vol.14 (22), p.3581-3587

2003

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Correction to Synthesis of Vaniprevir (MK-7009): Lactamization To Prepare a 22-Membered Macrocycle

Journal of organic chemistry, 2011-11, Vol.76 (22), p.9553-9553

2011

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An Efficient Chemoenzymatic Approach to (S)-γ-Fluoroleucine Ethyl Ester

Journal of organic chemistry, 2005-03, Vol.70 (6), p.2372-2375

2005

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Asymmetric Diels-Alder reactions of carboxylic ester dienophiles promoted by chiral Lewis acids

Journal of organic chemistry, 1992-01, Vol.57 (1), p.396-399

1992

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Design of an in vitro biocatalytic cascade for the manufacture of islatravir

Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture

Biocatalysis in drug discovery and development

Advances in the Enzymatic Reduction of Ketones

Hemoprotein‐Catalyzed Cyclopropanation En Route to the Chiral Cyclopropanol Fragment of Grazoprevir

Extending the application of biocatalysis to meet the challenges of drug development

A kinase-cGAS cascade to synthesize a therapeutic STING activator

Diastereoselective Reductive Amination of Aryl Trifluoromethyl Ketones and α-Amino Esters

Efficient Synthesis of NK1 Receptor Antagonist Aprepitant Using a Crystallization-Induced Diastereoselective Transformation

Palladium-Catalyzed Regioselective Arylation of Imidazo[1,2-b][1,2,4]triazine: Synthesis of an α2/ 3-Selective GABA Agonist

A chemoenzymatic strategy for site-selective functionalization of native peptides and proteins

Facile Synthesis of 2-Bromo-3-fluorobenzonitrile: An Application and Study of the Halodeboronation of Aryl Boronic Acids

Synthesis of a Tertiary Carbinamide via a Novel Rh-Catalyzed Asymmetric Hydrogenation

Convergent Kilogram-Scale Synthesis of Dual Orexin Receptor Antagonist

Asymmetric Synthesis of cis-2,5-Disubstituted Pyrrolidine, the Core Scaffold of β3‑AR Agonists

Synthesis of Vaniprevir (MK-7009): Lactamization To Prepare a 22-Membered Macrocycle

Chemo- and Enantioselective Routes to Chiral Fluorinated Hydroxyketones Using Ketoreductases

Practical Synthesis of A Macrocyclic HCV Protease Inhibitor: A High-Yielding Macrolactam Formation

Production of ( S ) - γ -fluoroleucine ethyl ester by enzyme mediated dynamic kinetic resolution: Comparison of batch and fed batch stirred tank processes to a packed bed column reactor

A generic platform for the immobilisation of engineered biocatalysts

An Asymmetric Synthesis of 3-Aryl-1,4-oxazin-2-ones: Synthesis of a Key Intermediate of an NK1 Receptor Antagonist

Scalable, efficient process for the synthesis of ( R)-3,5-bistrifluoromethylphenyl ethanol via catalytic asymmetric transfer hydrogenation and isolation as a DABCO inclusion complex

Correction to Synthesis of Vaniprevir (MK-7009): Lactamization To Prepare a 22-Membered Macrocycle

An Efficient Chemoenzymatic Approach to (S)-γ-Fluoroleucine Ethyl Ester

Asymmetric Diels-Alder reactions of carboxylic ester dienophiles promoted by chiral Lewis acids

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