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Rationally Designed Variants of α-Synuclein Illuminate Its in vivo Structural Properties in Health and Disease

Frontiers in neuroscience, 2018-09, Vol.12, p.623-623

Dettmer, Ulf

2018

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Parkinson’s disease: proteinopathy or lipidopathy?

NPJ Parkinson's Disease, 2020-01, Vol.6 (1), p.3-9, Article 3

2020

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Interactions of alpha-synuclein with membranes in Parkinson's disease: Mechanisms and therapeutic strategies

Neurobiology of disease, 2024-10, Vol.201, p.106646, Article 106646

2024

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Vesicle trafficking and lipid metabolism in synucleinopathy

Acta neuropathologica, 2021-04, Vol.141 (4), p.491-510

2021

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α-Synuclein serine129 phosphorylation - the physiology of pathology

Molecular neurodegeneration, 2023-11, Vol.18 (1), p.84-4, Article 84

2023

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KTKEGV repeat motifs are key mediators of normal α-synuclein tetramerization: Their mutation causes excess monomers and neurotoxicity

Proceedings of the National Academy of Sciences - PNAS, 2015-08, Vol.112 (31), p.9596-9601

2015

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Dynamic behaviors of α-synuclein and tau in the cellular context: New mechanistic insights and therapeutic opportunities in neurodegeneration

Neurobiology of disease, 2019-12, Vol.132, p.104543-104543, Article 104543

2019

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Astrocytes in Parkinson’s Disease: From Role to Possible Intervention

Cells (Basel, Switzerland), 2023-09, Vol.12 (19), p.2336

2023

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Brain region-specific susceptibility of Lewy body pathology in synucleinopathies is governed by α-synuclein conformations

Acta neuropathologica, 2022-04, Vol.143 (4), p.453-469

2022

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Lipotoxicity Downstream of α-Synuclein Imbalance: A Relevant Pathomechanism in Synucleinopathies?

Biomolecules (Basel, Switzerland), 2021-12, Vol.12 (1), p.40

2021

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A new method for quantitative immunoblotting of endogenous α-synuclein

PloS one, 2013-11, Vol.8 (11), p.e81314-e81314

2013

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Rapid Alpha-Synuclein Toxicity in a Neural Cell Model and Its Rescue by a Stearoyl-CoA Desaturase Inhibitor

International journal of molecular sciences, 2020-07, Vol.21 (15), p.5193

2020

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Temperature is a key determinant of alpha- and beta-synuclein membrane interactions in neurons

The Journal of biological chemistry, 2021-01, Vol.296, p.100271-100271, Article 100271

2021

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Nortriptyline inhibits aggregation and neurotoxicity of alpha-synuclein by enhancing reconfiguration of the monomeric form

Neurobiology of disease, 2017-10, Vol.106, p.191-204

2017

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Dynamic physiological α-synuclein S129 phosphorylation is driven by neuronal activity

NPJ Parkinson's Disease, 2023-01, Vol.9 (1), p.4-15, Article 4

2023

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Parkinson-causing mutations in LRRK2 impair the physiological tetramerization of endogenous α-synuclein in human neurons

NPJ Parkinson's Disease, 2022-09, Vol.8 (1), p.118-118, Article 118

2022

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Synuclein serine129 phosphorylation - the physiology of pathology

Molecular neurodegeneration, 2023-11, Vol.18 (1)

2023

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Generation of G51D and 3D mice reveals decreased α-synuclein tetramer-monomer ratios promote Parkinson’s disease phenotypes

NPJ Parkinson's Disease, 2024-02, Vol.10 (1), p.47-12, Article 47

2024

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1,4-Diurea- and 1,4-Dithiourea-Substituted Aromatic Derivatives Selectively Inhibit α‑Synuclein Oligomer Formation In Vitro

ACS omega, 2024-01, Vol.9 (1), p.1216-1229

2024

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Author Correction: Generation of G51D and 3D mice reveals decreased α-synuclein tetramer-monomer ratios promote Parkinson’s disease phenotypes

NPJ Parkinson's Disease, 2024-03, Vol.10 (1), p.57-57, Article 57

2024

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A stem cell-based assay platform demonstrates alpha-synuclein dependent synaptic dysfunction in patient-derived cortical neurons

NPJ Parkinson's Disease, 2024-05, Vol.10 (1), p.107-8, Article 107

2024

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Discovery of 4-aminoindole carboxamide derivatives to curtail alpha-synuclein and tau isoform 2N4R oligomer formation

Results in Chemistry, 2023-01, Vol.5, p.100938, Article 100938

2023

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Physiological roles of α-synuclein serine-129 phosphorylation – not an oxymoron

Trends in neurosciences (Regular ed.), 2024-07, Vol.47 (7), p.480-490

2024

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New insights into cellular α-synuclein homeostasis in health and disease

Current opinion in neurobiology, 2016-02, Vol.36, p.15-22

2016

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Transmembrane Protein 147 (TMEM147) Is a Novel Component of the Nicalin-NOMO Protein Complex

The Journal of biological chemistry, 2010-08, Vol.285 (34), p.26174-26181

2010

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Rationally Designed Variants of α-Synuclein Illuminate Its in vivo Structural Properties in Health and Disease

Parkinson’s disease: proteinopathy or lipidopathy?

Interactions of alpha-synuclein with membranes in Parkinson's disease: Mechanisms and therapeutic strategies

Vesicle trafficking and lipid metabolism in synucleinopathy

α-Synuclein serine129 phosphorylation - the physiology of pathology

KTKEGV repeat motifs are key mediators of normal α-synuclein tetramerization: Their mutation causes excess monomers and neurotoxicity

Dynamic behaviors of α-synuclein and tau in the cellular context: New mechanistic insights and therapeutic opportunities in neurodegeneration

Astrocytes in Parkinson’s Disease: From Role to Possible Intervention

Brain region-specific susceptibility of Lewy body pathology in synucleinopathies is governed by α-synuclein conformations

Lipotoxicity Downstream of α-Synuclein Imbalance: A Relevant Pathomechanism in Synucleinopathies?

A new method for quantitative immunoblotting of endogenous α-synuclein

Rapid Alpha-Synuclein Toxicity in a Neural Cell Model and Its Rescue by a Stearoyl-CoA Desaturase Inhibitor

Temperature is a key determinant of alpha- and beta-synuclein membrane interactions in neurons

Nortriptyline inhibits aggregation and neurotoxicity of alpha-synuclein by enhancing reconfiguration of the monomeric form

Dynamic physiological α-synuclein S129 phosphorylation is driven by neuronal activity

Parkinson-causing mutations in LRRK2 impair the physiological tetramerization of endogenous α-synuclein in human neurons

Synuclein serine129 phosphorylation - the physiology of pathology

Generation of G51D and 3D mice reveals decreased α-synuclein tetramer-monomer ratios promote Parkinson’s disease phenotypes

1,4-Diurea- and 1,4-Dithiourea-Substituted Aromatic Derivatives Selectively Inhibit α‑Synuclein Oligomer Formation In Vitro

Author Correction: Generation of G51D and 3D mice reveals decreased α-synuclein tetramer-monomer ratios promote Parkinson’s disease phenotypes

A stem cell-based assay platform demonstrates alpha-synuclein dependent synaptic dysfunction in patient-derived cortical neurons

Discovery of 4-aminoindole carboxamide derivatives to curtail alpha-synuclein and tau isoform 2N4R oligomer formation

Physiological roles of α-synuclein serine-129 phosphorylation – not an oxymoron

New insights into cellular α-synuclein homeostasis in health and disease

Transmembrane Protein 147 (TMEM147) Is a Novel Component of the Nicalin-NOMO Protein Complex

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