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Selective Inhibition of ras-Dependent Transformation by a Farnesyltransferase Inhibitor

Science (American Association for the Advancement of Science), 1993-06, Vol.260 (5116), p.1934-1937

1993

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Protein Farnesyltransferase Inhibitors Block the Growth of ras-Dependent Tumors in Nude Mice

Proceedings of the National Academy of Sciences - PNAS, 1994-09, Vol.91 (19), p.9141-9145

1994

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Farnesyltransferase inhibition causes morphological reversion of ras-transformed cells by a complex mechanism that involves regulation of the actin cytoskeleton

Molecular and Cellular Biology, 1994-06, Vol.14 (6), p.4193-4202

1994

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A priori prediction of activity for HIV-1 protease inhibitors employing energy minimization in the active site

Journal of medicinal chemistry, 1995-01, Vol.38 (2), p.305-317

1995

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Evaluation of farnesyl:Protein transferase and geranylgeranyl:Protein transferase inhibitor combinations in preclinical models

Cancer research (Chicago, Ill.), 2001-12, Vol.61 (24), p.8758-8768

2001

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Potent, non-thiol inhibitors of farnesyltransferase

Bioorganic & medicinal chemistry letters, 1998-12, Vol.8 (23), p.3311-3316

1998

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Metabolism of synthetic inositol trisphosphate analogs

The Journal of biological chemistry, 1988-08, Vol.263 (24), p.11922-11927

1988

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L-687,908, a potent hydroxyethylene containing HIV protease inhibitor

Journal of medicinal chemistry, 1991-03, Vol.34 (3), p.1225-1228

1991

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NMR studies of novel inhibitors bound to farnesyl‐protein transferase

Protein science, 1995-04, Vol.4 (4), p.681-688

1995

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N-Arylalkyl Pseudopeptide Inhibitors of Farnesyltransferase

Journal of medicinal chemistry, 1998-07, Vol.41 (14), p.2651-2656

1998

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Farnesyltransferase inhibitors and anti-Ras therapy

Breast cancer research and treatment, 1996-01, Vol.38 (1), p.75-83

1996

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Pseudodipeptide Inhibitors of Protein Farnesyltransferase

Journal of medicinal chemistry, 1995-09, Vol.38 (20), p.3967-3971

1995

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Farnesyltransferase inhibitors: a new class of cancer chemotherapeutics

Biochemical Society transactions, 1996-08, Vol.24 (3), p.688-692

1996

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Design and synthesis of HIV protease inhibitors. Variations of the carboxy terminus of the HIV protease inhibitor L-682,679

Journal of medicinal chemistry, 1991-09, Vol.34 (9), p.2852-2857

1991

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Farnesyl: proteintransferase inhibitors as agents to inhibit tumor growth

BioFactors (Oxford), 1997, Vol.6 (3), p.359-366

1997

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Mutational analysis of conserved residues of the beta-subunit of human farnesyl:protein transferase

The Journal of biological chemistry, 1997-10, Vol.272 (43), p.27319-27323

1997

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P450 interaction with farnesyl-protein transferase inhibitors metabolic stability, inhibitory potency, and P450 binding spectra in human liver microsomes

Biochemical pharmacology, 2001-09, Vol.62 (6), p.773-776

2001

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Topically active carbonic anhydrase inhibitors. 1. O-Acyl derivatives of 6-hydroxybenzothiazole-2-sulfonamide

Journal of medicinal chemistry, 1989-11, Vol.32 (11), p.2486-2492

1989

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Pseudopeptide inhibitors of Ras farnesyl-protein transferase

Journal of medicinal chemistry, 1994-03, Vol.37 (6), p.725-732

1994

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Diaryl ether inhibitors of farnesyl-protein transferase

Bioorganic & medicinal chemistry letters, 2001-05, Vol.11 (10), p.1257-1260

2001

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(Acylaryloxy)acetic acid diuretics. 5. [(2-Alkyl- and 2,2-disubstituted-1,3-dioxo-5-indanyl)oxy]acetic acids

Journal of medicinal chemistry, 1984-07, Vol.27 (7), p.840-845

1984

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Structure-affinity relationships of arylquinolizines at .alpha.-adrenoceptors

Journal of medicinal chemistry, 1988-03, Vol.31 (3), p.641-645

1988

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2-(Aminomethyl)phenols, a new class of saluretic agents. 1. Effects of nuclear substitution

Journal of medicinal chemistry, 1980-12, Vol.23 (12), p.1414-1427

1980

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2-(Aminomethyl)phenols, a new class of saluretic agents. 4. Effects of oxygen and/or nitrogen substitution

Journal of medicinal chemistry, 1982-06, Vol.25 (6), p.735-742

1982

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2-(Aminomethyl)phenols, a new class of saluretic agents. 3. Effects of functional group reorientation and modification

Journal of medicinal chemistry, 1981-09, Vol.24 (9), p.1063-1067

1981

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Selective Inhibition of ras-Dependent Transformation by a Farnesyltransferase Inhibitor

Protein Farnesyltransferase Inhibitors Block the Growth of ras-Dependent Tumors in Nude Mice

Farnesyltransferase inhibition causes morphological reversion of ras-transformed cells by a complex mechanism that involves regulation of the actin cytoskeleton

A priori prediction of activity for HIV-1 protease inhibitors employing energy minimization in the active site

Evaluation of farnesyl:Protein transferase and geranylgeranyl:Protein transferase inhibitor combinations in preclinical models

Potent, non-thiol inhibitors of farnesyltransferase

Metabolism of synthetic inositol trisphosphate analogs

L-687,908, a potent hydroxyethylene containing HIV protease inhibitor

NMR studies of novel inhibitors bound to farnesyl‐protein transferase

N-Arylalkyl Pseudopeptide Inhibitors of Farnesyltransferase

Farnesyltransferase inhibitors and anti-Ras therapy

Pseudodipeptide Inhibitors of Protein Farnesyltransferase

Farnesyltransferase inhibitors: a new class of cancer chemotherapeutics

Design and synthesis of HIV protease inhibitors. Variations of the carboxy terminus of the HIV protease inhibitor L-682,679

Farnesyl: proteintransferase inhibitors as agents to inhibit tumor growth

Mutational analysis of conserved residues of the beta-subunit of human farnesyl:protein transferase

P450 interaction with farnesyl-protein transferase inhibitors metabolic stability, inhibitory potency, and P450 binding spectra in human liver microsomes

Topically active carbonic anhydrase inhibitors. 1. O-Acyl derivatives of 6-hydroxybenzothiazole-2-sulfonamide

Pseudopeptide inhibitors of Ras farnesyl-protein transferase

Diaryl ether inhibitors of farnesyl-protein transferase

(Acylaryloxy)acetic acid diuretics. 5. [(2-Alkyl- and 2,2-disubstituted-1,3-dioxo-5-indanyl)oxy]acetic acids

Structure-affinity relationships of arylquinolizines at .alpha.-adrenoceptors

2-(Aminomethyl)phenols, a new class of saluretic agents. 1. Effects of nuclear substitution

2-(Aminomethyl)phenols, a new class of saluretic agents. 4. Effects of oxygen and/or nitrogen substitution

2-(Aminomethyl)phenols, a new class of saluretic agents. 3. Effects of functional group reorientation and modification

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