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Nbs1 Converts the Human Mre11/Rad50 Nuclease Complex into an Endo/Exonuclease Machine Specific for Protein-DNA Adducts

Molecular cell, 2016-11, Vol.64 (3), p.593-606

2016

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Mre11 Is Essential for the Removal of Lethal Topoisomerase 2 Covalent Cleavage Complexes

Molecular cell, 2016-11, Vol.64 (3), p.580-592

2016

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Catalytic and Noncatalytic Roles of the CtIP Endonuclease in Double-Strand Break End Resection

Molecular cell, 2014-06, Vol.54 (6), p.1022-1033

2014

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ATM and PRDM9 regulate SPO11-bound recombination intermediates during meiosis

Nature communications, 2020-02, Vol.11 (1), p.857-857, Article 857

2020

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EXD2 promotes homologous recombination by facilitating DNA end resection

Nature cell biology, 2016-03, Vol.18 (3), p.271-280

2016

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Single-Molecule Imaging Reveals How Mre11-Rad50-Nbs1 Initiates DNA Break Repair

Molecular cell, 2017-09, Vol.67 (5), p.891-898.e4

2017

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Genome-wide analysis of DNA-PK-bound MRN cleavage products supports a sequential model of DSB repair pathway choice

Nature communications, 2023-09, Vol.14 (1), p.5759-17, Article 5759

2023

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Rad50 ATPase activity is regulated by DNA ends and requires coordination of both active sites

Nucleic acids research, 2017-05, Vol.45 (9), p.5255-5268

2017

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ATM activation in the presence of oxidative stress

Cell cycle (Georgetown, Tex.), 2010-12, Vol.9 (24), p.4805-4811

2010

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The Mre11/Rad50/Nbs1 complex: Recent insights into catalytic activities and ATP-driven conformational changes

Experimental cell research, 2014-11, Vol.329 (1), p.139-147

2014

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Ataxia Telangiectasia-Mutated (ATM) Kinase Activity Is Regulated by ATP-driven Conformational Changes in the Mre11/Rad50/Nbs1 (MRN) Complex

The Journal of biological chemistry, 2013-05, Vol.288 (18), p.12840-12851

2013

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Mre11 Is Essential for the Removal of Lethal Topoisomerase 2 Covalent Cleavage Complexes

Molecular cell, 2016-12, Vol.64 (5), p.1010-1010

2016

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ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling

The EMBO journal, 2014-03, Vol.33 (5), p.482-500

2014

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DNA-dependent protein kinase promotes DNA end processing by MRN and CtIP

Science advances, 2020-01, Vol.6 (2), p.eaay0922-eaay0922

2020

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Genetic Separation of Sae2 Nuclease Activity from Mre11 Nuclease Functions in Budding Yeast

Molecular and cellular biology, 2017-12, Vol.37 (24)

2017

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TRIP13 Participates in Immediate-Early Sensing of DNA Strand Breaks and ATM Signaling Amplification through MRE11

Cells (Basel, Switzerland), 2022-12, Vol.11 (24), p.4095

2022

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METTL16 antagonizes MRE11-mediated DNA end resection and confers synthetic lethality to PARP inhibition in pancreatic ductal adenocarcinoma

Nature cancer, 2022-09, Vol.3 (9), p.1088-1104

2022

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Characterization of DNA-PK-Bound End Fragments Using GLASS-ChIP

Methods in molecular biology (Clifton, N.J.), 2022, Vol.2444, p.171

2022

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Abstract 2566: The MRN complex and regulation of recombination in eukaryotic cells

The Journal of biological chemistry, 2023, Vol.299 (3), p.103478, Article 103478

2023

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Purification and Biophysical Characterization of the Mre11-Rad50-Nbs1 Complex

Methods in molecular biology (Clifton, N.J.), 2019, Vol.2004, p.269

2019

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Characterization of DNA-PK-bound end fragments using GLASS-ChIP

Methods in enzymology, 2021, Vol.661, p.205-217

2021

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Modes of interaction among yeast Nej1, Lif1 and Dnl4 proteins and comparison to human XLF, XRCC4 and Lig4

DNA repair, 2007-10, Vol.6 (10), p.1507-1516

2007

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ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling

The EMBO journal, 2016-04, Vol.35 (7), p.791-791

2016

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Ribonucleases from T2 Family

Critical reviews in microbiology, 2002, Vol.28 (2), p.79-122

2002

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The Role of Yeast DNA 3′-Phosphatase Tpp1 and Rad1/Rad10 Endonuclease in Processing Spontaneous and Induced Base Lesions

The Journal of biological chemistry, 2003-08, Vol.278 (33), p.31434-31443

2003

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Nbs1 Converts the Human Mre11/Rad50 Nuclease Complex into an Endo/Exonuclease Machine Specific for Protein-DNA Adducts

Mre11 Is Essential for the Removal of Lethal Topoisomerase 2 Covalent Cleavage Complexes

Catalytic and Noncatalytic Roles of the CtIP Endonuclease in Double-Strand Break End Resection

ATM and PRDM9 regulate SPO11-bound recombination intermediates during meiosis

EXD2 promotes homologous recombination by facilitating DNA end resection

Single-Molecule Imaging Reveals How Mre11-Rad50-Nbs1 Initiates DNA Break Repair

Genome-wide analysis of DNA-PK-bound MRN cleavage products supports a sequential model of DSB repair pathway choice

Rad50 ATPase activity is regulated by DNA ends and requires coordination of both active sites

ATM activation in the presence of oxidative stress

The Mre11/Rad50/Nbs1 complex: Recent insights into catalytic activities and ATP-driven conformational changes

Ataxia Telangiectasia-Mutated (ATM) Kinase Activity Is Regulated by ATP-driven Conformational Changes in the Mre11/Rad50/Nbs1 (MRN) Complex

Mre11 Is Essential for the Removal of Lethal Topoisomerase 2 Covalent Cleavage Complexes

ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling

DNA-dependent protein kinase promotes DNA end processing by MRN and CtIP

Genetic Separation of Sae2 Nuclease Activity from Mre11 Nuclease Functions in Budding Yeast

TRIP13 Participates in Immediate-Early Sensing of DNA Strand Breaks and ATM Signaling Amplification through MRE11

METTL16 antagonizes MRE11-mediated DNA end resection and confers synthetic lethality to PARP inhibition in pancreatic ductal adenocarcinoma

Characterization of DNA-PK-Bound End Fragments Using GLASS-ChIP

Abstract 2566: The MRN complex and regulation of recombination in eukaryotic cells

Purification and Biophysical Characterization of the Mre11-Rad50-Nbs1 Complex

Characterization of DNA-PK-bound end fragments using GLASS-ChIP

Modes of interaction among yeast Nej1, Lif1 and Dnl4 proteins and comparison to human XLF, XRCC4 and Lig4

ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling

Ribonucleases from T2 Family

The Role of Yeast DNA 3′-Phosphatase Tpp1 and Rad1/Rad10 Endonuclease in Processing Spontaneous and Induced Base Lesions

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