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Heteroleptic ruthenium bis-terpyridine complexes bearing a 4-(dimethylamino)phenyl donor and free coordination sites for hydrogen photo-evolution

Dalton transactions : an international journal of inorganic chemistry, 2019-10, Vol.48 (4), p.15136-15143

2019

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The discovery and synthesis of highly potent subtype selective phosphodiesterase 4D inhibitors

Bioorganic & medicinal chemistry letters, 2010-09, Vol.20 (18), p.5502-5505

2010

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Discovery of MK-1439, an orally bioavailable non-nucleoside reverse transcriptase inhibitor potent against a wide range of resistant mutant HIV viruses

Bioorganic & medicinal chemistry letters, 2014-02, Vol.24 (3), p.917-922

2014

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identification of 4,7-disubstituted naphthoic acid derivatives as UDP-competitive antagonists of P2Y

Bioorganic & medicinal chemistry letters, 2011-05, Vol.21 (10), p.2836-2839

2011

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The identification of 4,7-disubstituted naphthoic acid derivatives as UDP-competitive antagonists of P2Y14

Bioorganic & medicinal chemistry letters, 2011-05, Vol.21 (10), p.2836-2839

2011

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Enantiospecific synthesis via sequential diastereofacial and diastereotopic group selective reactions: enantiodivergent synthesis of syn-1,3-polyols

Journal of the American Chemical Society, 1992-01, Vol.114 (3), p.1090-1091

1992

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Difluoroethylamines as an amide isostere in inhibitors of cathepsin K

Bioorganic & medicinal chemistry letters, 2011-02, Vol.21 (3), p.920-923

2011

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Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438)

Bioorganic & medicinal chemistry letters, 2010-01, Vol.20 (2), p.499-502

2010

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Identification of a potent and selective non-basic cathepsin K inhibitor

Bioorganic & medicinal chemistry letters, 2006-04, Vol.16 (7), p.1985-1989

2006

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Nicotinic acids: Liver-targeted SCD inhibitors with preclinical anti-diabetic efficacy

Bioorganic & medicinal chemistry letters, 2011-12, Vol.21 (24), p.7281-7286

2011

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Structure-activity relationships and pharmacokinetic parameters of quinoline acylsulfonamides as potent and selective antagonists of the EP4 receptor

Bioorganic & medicinal chemistry letters, 2008-03, Vol.18 (6), p.2048-2054

2008

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Design, synthesis, and biological evaluation of 8-biarylquinolines: A novel class of PDE4 inhibitors

Bioorganic & medicinal chemistry, 2008-02, Vol.18 (4), p.1407-1412

2008

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Alkyl-bridged substituted 8-arylquinolines as highly potent PDE IV inhibitors

Bioorganic & medicinal chemistry letters, 2009-09, Vol.19 (17), p.5266-5269

2009

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Nitrogen-bridged substituted 8-arylquinolines as potent PDE IV inhibitors

Bioorganic & medicinal chemistry letters, 2006-05, Vol.16 (10), p.2608-2612

2006

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The identification of 4,7-disubstituted naphthoic acid derivatives as UDP-competitive antagonists of P2Y sub(14)

Bioorganic & medicinal chemistry letters, 2011-05, Vol.21 (10), p.2836-2839

2011

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Structure-activity relationships and pharmacokinetic parameters of quinoline acylsulfonamides as potent and selective antagonists of the EP sub(4) receptor

Bioorganic & medicinal chemistry, 2008-03, Vol.18 (6), p.2048-2054

2008

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The chemo- and enantioselective cyclopropanation of polyenes: chiral auxiliary vs chiral reagent-based approach

Tetrahedron letters, 1996-10, Vol.37 (44), p.7925-7928

1996

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Design, synthesis, and supramolecular properties of bis-crown ether modified peptides

Supramolecular chemistry, 1995-05, Vol.5 (1), p.61-69

1995

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2-Pyridinyl-3-(4-methylsulfonyl)phenylpyridines: Selective and orally active cyclooxygenase-2 inhibitors

Bioorganic & medicinal chemistry letters, 1998-10, Vol.8 (19), p.2777-2782

1998

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Process Development and Large-Scale Synthesis of a PDE4 Inhibitor

Organic process research & development, 2006-01, Vol.10 (1), p.36-45

2006

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The identification of 4,7-disubstituted naphthoic acid derivatives as UDP-competitive antagonists of P2Y 14

Bioorganic & medicinal chemistry letters, 2011, Vol.21 (10), p.2836-2839

2011

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Structure–activity relationships and pharmacokinetic parameters of quinoline acylsulfonamides as potent and selective antagonists of the EP 4 receptor

Bioorganic & medicinal chemistry letters, 2008, Vol.18 (6), p.2048-2054

2008

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2-Heterosubstituted-3-(4-methylsulfonyl)phenyl-5-trifluoromethyl pyridines as selective and orally active cyclooxygenase-2 inhibitors

Bioorganic & medicinal chemistry letters, 1999-06, Vol.9 (12), p.1715-1720

1999

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Heteroleptic ruthenium bis-terpyridine complexes bearing a 4-(dimethylamino)phenyl donor and free coordination sites for hydrogen photo-evolution

The discovery and synthesis of highly potent subtype selective phosphodiesterase 4D inhibitors

Discovery of MK-1439, an orally bioavailable non-nucleoside reverse transcriptase inhibitor potent against a wide range of resistant mutant HIV viruses

identification of 4,7-disubstituted naphthoic acid derivatives as UDP-competitive antagonists of P2Y

The identification of 4,7-disubstituted naphthoic acid derivatives as UDP-competitive antagonists of P2Y14

Enantiospecific synthesis via sequential diastereofacial and diastereotopic group selective reactions: enantiodivergent synthesis of syn-1,3-polyols

Difluoroethylamines as an amide isostere in inhibitors of cathepsin K

Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438)

Identification of a potent and selective non-basic cathepsin K inhibitor

Nicotinic acids: Liver-targeted SCD inhibitors with preclinical anti-diabetic efficacy

Structure-activity relationships and pharmacokinetic parameters of quinoline acylsulfonamides as potent and selective antagonists of the EP4 receptor

Design, synthesis, and biological evaluation of 8-biarylquinolines: A novel class of PDE4 inhibitors

Alkyl-bridged substituted 8-arylquinolines as highly potent PDE IV inhibitors

Nitrogen-bridged substituted 8-arylquinolines as potent PDE IV inhibitors

The identification of 4,7-disubstituted naphthoic acid derivatives as UDP-competitive antagonists of P2Y sub(14)

Structure-activity relationships and pharmacokinetic parameters of quinoline acylsulfonamides as potent and selective antagonists of the EP sub(4) receptor

The chemo- and enantioselective cyclopropanation of polyenes: chiral auxiliary vs chiral reagent-based approach

Design, synthesis, and supramolecular properties of bis-crown ether modified peptides

Discovery of a substituted 8-arylquinoline series of PED4 inhibitors : Structure-activity relationship, optimization, and identification of a highly potent, well tolerated, PDE4 inhibitor

2-Pyridinyl-3-(4-methylsulfonyl)phenylpyridines: Selective and orally active cyclooxygenase-2 inhibitors

Process Development and Large-Scale Synthesis of a PDE4 Inhibitor

Discovery of a substituted 8-arylquinoline series of PDE4 inhibitors: Structure–activity relationship, optimization, and identification of a highly potent, well tolerated, PDE4 inhibitor

The identification of 4,7-disubstituted naphthoic acid derivatives as UDP-competitive antagonists of P2Y 14

Structure–activity relationships and pharmacokinetic parameters of quinoline acylsulfonamides as potent and selective antagonists of the EP 4 receptor

2-Heterosubstituted-3-(4-methylsulfonyl)phenyl-5-trifluoromethyl pyridines as selective and orally active cyclooxygenase-2 inhibitors

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