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Gender-based differences in brain and plasma pharmacokinetics of letrozole in sprague-dawley rats: Application of physiologically-based pharmacokinetic modeling to gain quantitative insights

PloS one, 2021-04, Vol.16 (4), p.e0248579

2021

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A Review of Approaches to Potentiate the Activity of Temozolomide against Glioblastoma to Overcome Resistance

International journal of molecular sciences, 2024-03, Vol.25 (6), p.3217

2024

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The pharmacokinetics of acyl, des-acyl, and total ghrelin in healthy human subjects

European journal of endocrinology, 2013-06, Vol.168 (6), p.821-828

2013

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Intestinal human colon adenocarcinoma cell line LS180 is an excellent model to study pregnane X receptor, but not constitutive androstane receptor, mediated CYP3A4 and multidrug resistance transporter 1 induction: studies with anti-human immunodeficiency virus protease inhibitors

Drug metabolism and disposition, 2008-06, Vol.36 (6), p.1172-1180

2008

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A First-In-Class, Humanized Antibody Targeting Alternatively Spliced Tissue Factor: Preclinical Evaluation in an Orthotopic Model of Pancreatic Ductal Adenocarcinoma

Frontiers in oncology, 2021-07, Vol.11, p.691685-691685

2021

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Bioavailability, Disposition, and Dose-Response Effects of Soy Isoflavones When Consumed by Healthy Women at Physiologically Typical Dietary Intakes

The Journal of nutrition, 2003-04, Vol.133 (4), p.1027-1035

2003

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Evaluation of Vancomycin Use in Late-Onset Neonatal Sepsis Using the Area Under the Concentration-Time Curve to the Minimum Inhibitory Concentration ≥400 Target

Therapeutic drug monitoring, 2015-12, Vol.37 (6), p.756-765

2015

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Manipulation of olfactory tight junctions using papaverine to enhance intranasal delivery of gemcitabine to the brain

Drug delivery, 2014-02, Vol.21 (1), p.8-16

2014

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Biotherapy of Brain Tumors with Phosphatidylserine-Targeted Radioiodinated SapC-DOPS Nanovesicles

Cells (Basel, Switzerland), 2020-08, Vol.9 (9), p.1960

2020

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Acylhydrazones as Antifungal Agents Targeting the Synthesis of Fungal Sphingolipids

Antimicrobial agents and chemotherapy, 2018-05, Vol.62 (5)

2018

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Preclinical pharmacokinetic evaluation to facilitate repurposing of tyrosine kinase inhibitors nilotinib and imatinib as antiviral agents

BMC pharmacology & toxicology, 2018-12, Vol.19 (1), p.80-11, Article 80

2018

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Phase 1 dose‐finding study of metformin in combination with concurrent cisplatin and radiotherapy in patients with locally advanced head and neck squamous cell cancer

Cancer, 2020-01, Vol.126 (2), p.354-362

2020

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Brain pharmacokinetics and metabolism of the AMP-activated protein kinase selective inhibitor SBI-0206965, an investigational agent for the treatment of glioblastoma

Investigational new drugs, 2022-10, Vol.40 (5), p.944-952

2022

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A Phase 0/I Pharmacokinetic and Pharmacodynamics and Safety and Tolerability Study of Letrozole in Combination with Standard Therapy in Recurrent High-Grade Gliomas

Clinical cancer research, 2024-05, Vol.30 (10), p.2068-2077

2024

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Plasma and brain pharmacokinetics of letrozole and drug interaction studies with temozolomide in NOD-scid gamma mice and sprague dawley rats

Cancer chemotherapy and pharmacology, 2019-01, Vol.83 (1), p.81-89

2019

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Potentiation of temozolomide activity against glioblastoma cells by aromatase inhibitor letrozole

Cancer chemotherapy and pharmacology, 2022-10, Vol.90 (4), p.345-356

2022

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Dose‐dependent Induction of Cytochrome P450 (CYP) 3A4 and Activation of Pregnane X Receptor by Topiramate

Epilepsia (Copenhagen), 2003-12, Vol.44 (12), p.1521-1528

2003

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Induction of cytochrome P450 3A4 in primary human hepatocytes and activation of the human pregnane X receptor by tamoxifen and 4-hydroxytamoxifen

Drug metabolism and disposition, 2002-05, Vol.30 (5), p.608-612

2002

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The pharmacokinetics of letrozole in brain and brain tumor in rats with orthotopically implanted C6 glioma, assessed using intracerebral microdialysis

Cancer chemotherapy and pharmacology, 2013-08, Vol.72 (2), p.349-357

2013

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Quantification of human hepatocyte cytochrome P450 enzymes and transporters induced by HIV protease inhibitors using newly validated LC-MS/MS cocktail assays and RT-PCR

Biopharmaceutics & drug disposition, 2012-05, Vol.33 (4), p.207-217

2012

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Role of human pregnane X receptor in tamoxifen- and 4-hydroxytamoxifen-mediated CYP3A4 induction in primary human hepatocytes and LS174T cells

Drug metabolism and disposition, 2008-05, Vol.36 (5), p.946-954

2008

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Steady-State Pharmacokinetic Interactions of Darunavir/Ritonavir With Lipid-Lowering Agent Rosuvastatin

Journal of clinical pharmacology, 2012-06, Vol.52 (6), p.922-931

2012

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Preclinical pharmacological evaluation of letrozole as a novel treatment for gliomas

Molecular cancer therapeutics, 2015-04, Vol.14 (4), p.857-864

2015

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Gender-based differences in brain and plasma pharmacokinetics of letrozole in sprague-dawley rats: Application of physiologically-based pharmacokinetic modeling to gain quantitative insights

A Review of Approaches to Potentiate the Activity of Temozolomide against Glioblastoma to Overcome Resistance

The pharmacokinetics of acyl, des-acyl, and total ghrelin in healthy human subjects

Intestinal human colon adenocarcinoma cell line LS180 is an excellent model to study pregnane X receptor, but not constitutive androstane receptor, mediated CYP3A4 and multidrug resistance transporter 1 induction: studies with anti-human immunodeficiency virus protease inhibitors

A First-In-Class, Humanized Antibody Targeting Alternatively Spliced Tissue Factor: Preclinical Evaluation in an Orthotopic Model of Pancreatic Ductal Adenocarcinoma

Bioavailability, Disposition, and Dose-Response Effects of Soy Isoflavones When Consumed by Healthy Women at Physiologically Typical Dietary Intakes

Evaluation of Vancomycin Use in Late-Onset Neonatal Sepsis Using the Area Under the Concentration-Time Curve to the Minimum Inhibitory Concentration ≥400 Target

Manipulation of olfactory tight junctions using papaverine to enhance intranasal delivery of gemcitabine to the brain

Biotherapy of Brain Tumors with Phosphatidylserine-Targeted Radioiodinated SapC-DOPS Nanovesicles

Acylhydrazones as Antifungal Agents Targeting the Synthesis of Fungal Sphingolipids

Preclinical pharmacokinetic evaluation to facilitate repurposing of tyrosine kinase inhibitors nilotinib and imatinib as antiviral agents

Phase 1 dose‐finding study of metformin in combination with concurrent cisplatin and radiotherapy in patients with locally advanced head and neck squamous cell cancer

Brain pharmacokinetics and metabolism of the AMP-activated protein kinase selective inhibitor SBI-0206965, an investigational agent for the treatment of glioblastoma

A Phase 0/I Pharmacokinetic and Pharmacodynamics and Safety and Tolerability Study of Letrozole in Combination with Standard Therapy in Recurrent High-Grade Gliomas

Plasma and brain pharmacokinetics of letrozole and drug interaction studies with temozolomide in NOD-scid gamma mice and sprague dawley rats

Potentiation of temozolomide activity against glioblastoma cells by aromatase inhibitor letrozole

Dose‐dependent Induction of Cytochrome P450 (CYP) 3A4 and Activation of Pregnane X Receptor by Topiramate

Induction of cytochrome P450 3A4 in primary human hepatocytes and activation of the human pregnane X receptor by tamoxifen and 4-hydroxytamoxifen

The pharmacokinetics of letrozole in brain and brain tumor in rats with orthotopically implanted C6 glioma, assessed using intracerebral microdialysis

Identification of a New Class of Antifungals Targeting the Synthesis of Fungal Sphingolipids

Quantification of human hepatocyte cytochrome P450 enzymes and transporters induced by HIV protease inhibitors using newly validated LC-MS/MS cocktail assays and RT-PCR

Role of human pregnane X receptor in tamoxifen- and 4-hydroxytamoxifen-mediated CYP3A4 induction in primary human hepatocytes and LS174T cells

Steady-State Pharmacokinetic Interactions of Darunavir/Ritonavir With Lipid-Lowering Agent Rosuvastatin

GABA(A) Receptor Activation Drives GABARAP-Nix Mediated Autophagy to Radiation-Sensitize Primary and Brain-Metastatic Lung Adenocarcinoma Tumors

Preclinical pharmacological evaluation of letrozole as a novel treatment for gliomas

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