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Understanding and overcoming trade-offs between antibody affinity, specificity, stability and solubility

Biochemical engineering journal, 2018-09, Vol.137, p.365-374

2018

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Co-optimization of therapeutic antibody affinity and specificity using machine learning models that generalize to novel mutational space

Nature communications, 2022-07, Vol.13 (1), p.3788-3788, Article 3788

2022

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A hybridoma-derived monoclonal antibody with high homology to the aberrant myeloma light chain

PloS one, 2021-10, Vol.16 (10), p.e0252558-e0252558

2021

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Highly sensitive detection of antibody nonspecific interactions using flow cytometry

mAbs, 2021-01, Vol.13 (1), p.1951426

2021

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Discovery and characterization of high-affinity, potent SARS-CoV-2 neutralizing antibodies via single B cell screening

Scientific reports, 2021-10, Vol.11 (1), p.20738-20738, Article 20738

2021

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Reduction of therapeutic antibody self-association using yeast-display selections and machine learning

mAbs, 2022, Vol.14 (1), p.2146629-2146629

2022

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Facile isolation of high-affinity nanobodies from synthetic libraries using CDR-swapping mutagenesis

STAR protocols, 2022-03, Vol.3 (1), p.101101-101101, Article 101101

2022

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Physicochemical Rules for Identifying Monoclonal Antibodies with Drug-like Specificity

Molecular pharmaceutics, 2020-07, Vol.17 (7), p.2555-2569

2020

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Native ion mobility‐mass spectrometry reveals the binding mechanisms of anti‐amyloid therapeutic antibodies

Protein science, 2024-06, Vol.33 (6), p.e5008-n/a

2024

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Directed evolution of potent neutralizing nanobodies against SARS-CoV-2 using CDR-swapping mutagenesis

Cell chemical biology, 2021-09, Vol.28 (9), p.1379-1388.e7

2021

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Isolating Anti-amyloid Antibodies from Yeast-Displayed Libraries

Methods in molecular biology (Clifton, N.J.), 2022, Vol.2491, p.471

2022

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Facile generation of biepitopic antibodies with intrinsic agonism for activating tumor necrosis factor receptors

Cell chemical biology, 2024-05, Vol.31 (5), p.944-954.e5

2024

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Development of a pan-tau multivalent nanobody that binds tau aggregation motifs and recognizes pathological tau aggregates

Biotechnology progress, 2024-09, Vol.40 (5), p.e3463

2024

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Rapid and Quantitative In Vitro Evaluation of SARS-CoV‑2 Neutralizing Antibodies and Nanobodies

Analytical chemistry (Washington), 2022-03, Vol.94 (10), p.4504-4512

2022

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Human antibody polyreactivity is governed primarily by the heavy-chain complementarity-determining regions

Cell reports (Cambridge), 2024-10, Vol.43 (10), p.114801, Article 114801

2024

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Nature-inspired design and evolution of anti-amyloid antibodies

The Journal of biological chemistry, 2019-05, Vol.294 (21), p.8438-8451

2019

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Rational affinity maturation of anti-amyloid antibodies with high conformational and sequence specificity

The Journal of biological chemistry, 2021-01, Vol.296, p.100508, Article 100508

2021

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Directed evolution of conformation‐specific antibodies for sensitive detection of polypeptide aggregates in therapeutic drug formulations

Biotechnology and bioengineering, 2021-02, Vol.118 (2), p.797-808

2021

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Sensitive detection of glucagon aggregation using amyloid fibril‐specific antibodies

Biotechnology and bioengineering, 2019-08, Vol.116 (8), p.1868-1877

2019

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Engineered Multivalent Nanobodies Potently and Broadly Neutralize SARS‐CoV‐2 Variants

Advanced therapeutics, 2021-08, Vol.4 (8), p.2100099-n/a

2021

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Directed Evolution of Antibodies Against Complex Targets

Desai, Alec A

2021

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Highly sensitive detection of antibody nonspecific interactions using flow cytometry

mAbs, 2021, Vol.13 (1)

2021

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Reduction of therapeutic antibody self-association using yeast-display selections and machine learning

mAbs, 2022, Vol.14 (1)

2022

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strategy for tissue self-organization that is robust to cellular heterogeneity and plasticity

Proceedings of the National Academy of Sciences - PNAS, 2015-02, Vol.112 (7), p.2287-2292

2015

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Programmed synthesis of three-dimensional tissues

Nature methods, 2015-10, Vol.12 (10), p.975-981

2015

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Understanding and overcoming trade-offs between antibody affinity, specificity, stability and solubility

Co-optimization of therapeutic antibody affinity and specificity using machine learning models that generalize to novel mutational space

A hybridoma-derived monoclonal antibody with high homology to the aberrant myeloma light chain

Highly sensitive detection of antibody nonspecific interactions using flow cytometry

Discovery and characterization of high-affinity, potent SARS-CoV-2 neutralizing antibodies via single B cell screening

Reduction of therapeutic antibody self-association using yeast-display selections and machine learning

Facile isolation of high-affinity nanobodies from synthetic libraries using CDR-swapping mutagenesis

Physicochemical Rules for Identifying Monoclonal Antibodies with Drug-like Specificity

Native ion mobility‐mass spectrometry reveals the binding mechanisms of anti‐amyloid therapeutic antibodies

Directed evolution of potent neutralizing nanobodies against SARS-CoV-2 using CDR-swapping mutagenesis

Isolating Anti-amyloid Antibodies from Yeast-Displayed Libraries

Facile generation of biepitopic antibodies with intrinsic agonism for activating tumor necrosis factor receptors

Development of a pan-tau multivalent nanobody that binds tau aggregation motifs and recognizes pathological tau aggregates

Rapid and Quantitative In Vitro Evaluation of SARS-CoV‑2 Neutralizing Antibodies and Nanobodies

Human antibody polyreactivity is governed primarily by the heavy-chain complementarity-determining regions

Nature-inspired design and evolution of anti-amyloid antibodies

Rational affinity maturation of anti-amyloid antibodies with high conformational and sequence specificity

Directed evolution of conformation‐specific antibodies for sensitive detection of polypeptide aggregates in therapeutic drug formulations

Sensitive detection of glucagon aggregation using amyloid fibril‐specific antibodies

Engineered Multivalent Nanobodies Potently and Broadly Neutralize SARS‐CoV‐2 Variants

Directed Evolution of Antibodies Against Complex Targets

Highly sensitive detection of antibody nonspecific interactions using flow cytometry

Reduction of therapeutic antibody self-association using yeast-display selections and machine learning

strategy for tissue self-organization that is robust to cellular heterogeneity and plasticity

Programmed synthesis of three-dimensional tissues

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