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Structural basis for the initiation of eukaryotic transcription-coupled DNA repair

Nature (London), 2017-11, Vol.551 (7682), p.653-657

2017

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Single position substitution of hairpin pyrrole-imidazole polyamides imparts distinct DNA-binding profiles across the human genome

PloS one, 2020-12, Vol.15 (12), p.e0243905

2020

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Allosteric modulation of DNA by small molecules

Proceedings of the National Academy of Sciences - PNAS, 2009-08, Vol.106 (32), p.13175-13179

2009

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A Pyrrole-Imidazole Polyamide Is Active against Enzalutamide-Resistant Prostate Cancer

Cancer research (Chicago, Ill.), 2017-05, Vol.77 (9), p.2207-2212

2017

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Suppression of androgen receptor-mediated gene expression by a sequence-specific DNA-binding polyamide

Proceedings of the National Academy of Sciences - PNAS, 2007-06, Vol.104 (25), p.10418-10423

2007

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Structural Basis for Cyclic Py-Im Polyamide Allosteric Inhibition of Nuclear Receptor Binding

Journal of the American Chemical Society, 2010-10, Vol.132 (41), p.14521-14529

2010

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Design of Sequence-Specific DNA Binding Molecules for DNA Methyltransferase Inhibition

Journal of the American Chemical Society, 2014-03, Vol.136 (9), p.3687-3694

2014

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Recognition of the DNA minor groove by pyrrole-imidazole polyamides

Current opinion in structural biology, 2003-06, Vol.13 (3), p.284-299

2003

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Stalled DNA Replication Forks at the Endogenous GAA Repeats Drive Repeat Expansion in Friedreich’s Ataxia Cells

Cell reports (Cambridge), 2016-08, Vol.16 (5), p.1218-1227

2016

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Antitumor activity of a pyrrole-imidazole polyamide

Proceedings of the National Academy of Sciences - PNAS, 2013-01, Vol.110 (5), p.1863-1868

2013

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Modulation of NF-κB-dependent gene transcription using programmable DNA minor groove binders

Proceedings of the National Academy of Sciences - PNAS, 2012-01, Vol.109 (4), p.1023-1028

2012

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Role of Mismatch Repair Enzymes in GAA·TTC Triplet-repeat Expansion in Friedreich Ataxia Induced Pluripotent Stem Cells

The Journal of biological chemistry, 2012-08, Vol.287 (35), p.29861-29872

2012

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An HRE-Binding Py-Im Polyamide Impairs Hypoxic Signaling in Tumors

Molecular cancer therapeutics, 2016-04, Vol.15 (4), p.608-617

2016

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Repression of DNA-binding dependent glucocorticoid receptor-mediated gene expression

Proceedings of the National Academy of Sciences - PNAS, 2009-09, Vol.106 (39), p.16598-16603

2009

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Interference with DNA repair after ionizing radiation by a pyrrole-imidazole polyamide

PloS one, 2018-05, Vol.13 (5), p.e0196803

2018

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Enhancing the cellular uptake of Py-Im polyamides through next-generation aryl turns

Nucleic acids research, 2012-03, Vol.40 (5), p.2345

2012

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RNA polymerase II senses obstruction in the DNA minor groove via a conserved sensor motif

Proceedings of the National Academy of Sciences - PNAS, 2016-11, Vol.113 (44), p.12426-12431

2016

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A sequence-specific DNA binding small molecule triggers the release of immunogenic signals and phagocytosis in a model of B-cell lymphoma

Quarterly reviews of biophysics, 2015-11, Vol.48 (4), p.453-464

2015

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A DNA-binding Molecule Targeting the Adaptive Hypoxic Response in Multiple Myeloma Has Potent Antitumor Activity

Molecular cancer research, 2016-03, Vol.14 (3), p.253-266

2016

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Molecular basis of antibiotic multiresistance transfer in Staphylococcus aureus

Proceedings of the National Academy of Sciences - PNAS, 2013-02, Vol.110 (8), p.2804-2809

2013

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Microwave Assisted Synthesis of Py-Im Polyamides

Organic letters, 2012-06, Vol.14 (11), p.2774-2777

2012

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Activity of a Py-Im polyamide targeted to the estrogen response element

Molecular cancer therapeutics, 2013-05, Vol.12 (5), p.675-684

2013

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Synthesis of Cyclic Py-Im Polyamide Libraries

Journal of organic chemistry, 2013-01, Vol.78 (1), p.124-133

2013

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Modifications at the C-Terminus To Improve Pyrrole−Imidazole Polyamide Activity in Cell Culture

Journal of medicinal chemistry, 2009-12, Vol.52 (23), p.7380-7388

2009

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Gene expression changes in a tumor xenograft by a pyrrole-imidazole polyamide

Proceedings of the National Academy of Sciences - PNAS, 2012-10, Vol.109 (40), p.16041-16045

2012

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Structural basis for the initiation of eukaryotic transcription-coupled DNA repair

Single position substitution of hairpin pyrrole-imidazole polyamides imparts distinct DNA-binding profiles across the human genome

Allosteric modulation of DNA by small molecules

A Pyrrole-Imidazole Polyamide Is Active against Enzalutamide-Resistant Prostate Cancer

Suppression of androgen receptor-mediated gene expression by a sequence-specific DNA-binding polyamide

Structural Basis for Cyclic Py-Im Polyamide Allosteric Inhibition of Nuclear Receptor Binding

Design of Sequence-Specific DNA Binding Molecules for DNA Methyltransferase Inhibition

Recognition of the DNA minor groove by pyrrole-imidazole polyamides

Stalled DNA Replication Forks at the Endogenous GAA Repeats Drive Repeat Expansion in Friedreich’s Ataxia Cells

Antitumor activity of a pyrrole-imidazole polyamide

Modulation of NF-κB-dependent gene transcription using programmable DNA minor groove binders

Role of Mismatch Repair Enzymes in GAA·TTC Triplet-repeat Expansion in Friedreich Ataxia Induced Pluripotent Stem Cells

An HRE-Binding Py-Im Polyamide Impairs Hypoxic Signaling in Tumors

Repression of DNA-binding dependent glucocorticoid receptor-mediated gene expression

Interference with DNA repair after ionizing radiation by a pyrrole-imidazole polyamide

Enhancing the cellular uptake of Py-Im polyamides through next-generation aryl turns

RNA polymerase II senses obstruction in the DNA minor groove via a conserved sensor motif

A sequence-specific DNA binding small molecule triggers the release of immunogenic signals and phagocytosis in a model of B-cell lymphoma

A DNA-binding Molecule Targeting the Adaptive Hypoxic Response in Multiple Myeloma Has Potent Antitumor Activity

Molecular basis of antibiotic multiresistance transfer in Staphylococcus aureus

Microwave Assisted Synthesis of Py-Im Polyamides

Activity of a Py-Im polyamide targeted to the estrogen response element

Synthesis of Cyclic Py-Im Polyamide Libraries

Modifications at the C-Terminus To Improve Pyrrole−Imidazole Polyamide Activity in Cell Culture

Gene expression changes in a tumor xenograft by a pyrrole-imidazole polyamide

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